Soluble Interleukin-2 Receptor as an Indicator of Immunological Disturbance Found in Silicosis Patients

Hayashi, Hiroaki; Maeda, Megumi; Murakami, Shuko; Kumagai, Naoya; Chen, Y.; Hatayama, Tamayo; Katoh, Masakazu; Miyahara, Naomi; Yamamoto, Shoko; Yoshida, Yoko; Nishimura, Yasumasa; Kusaka, Masayasu; Fujimoto, Wataru; Otsuki, Takemi

doi:10.1177/039463200902200107

Cited by 31 publications

(34 citation statements)

References 29 publications

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“…Our studies corroborate this tendency and revealed that silicosis patients show higher titers of anti-nuclear antibodies (ANA) compared with that of healthy donors [21,22]. Furthermore, we discovered several specific autoantibodies in silicosis patients.…”

Section: Autoantibodies Detectedsupporting

confidence: 83%

“…Thus, we measured serum sIL-2R levels in cases of silicosis [22]. Our results showed that these levels tended to be higher than those of healthy donors and lower than those of SSc patients, but the differences between groups were not significant.…”

Section: Chronic Activation Of Responder T Cellsmentioning

confidence: 67%

“…To resolve the relationship between serum sIL-2R levels and respiratory or immunological parameters in silicosis patients, the correlations between many clinical parameters were analyzed. sIL-2R levels showed a positive correlation with serum ANA titers and titers for anti-Scl-70 autoantibody or anti-centromere autoantibody [22]. Multi-regression analysis was then performed to determine which parameters were related to serum sIL-2R levels.…”

Section: Chronic Activation Of Responder T Cellsmentioning

confidence: 99%

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Silica exposure and altered regulation of autoimmunity

Lee

Matsuzaki

Kumagai-Τakei

et al. 2014

Environ Health Prev Med

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Silica particles and asbestos fibers, which are known as typical causatives of pneumoconiosis, induce lung fibrosis. Moreover, silicosis patients often complicate with autoimmune diseases, and asbestos-exposed patients suffer from malignant diseases such as pleural mesothelioma and lung cancer. We have been conducting experimental studies to investigate altered regulation of selftolerance caused by silica exposure, including analyses using specimens such as plasma and immunocompetent cells obtained from silicosis patients, as a means of examining the supposition that silica exposure induces molecular and cellular biological alterations of immune cells. These approaches have resulted in the detection of several specific autoantibodies, alterations of CD95/Fas and its related molecules, and evidence of chronic activation of responder T cells and regulatory T cells following silica exposure. In this review, we present details of our investigations as an introduction to scientific approaches examining the immunological effects of environmental and occupational substances.

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Section: Autoantibodies Detectedsupporting

confidence: 83%

Section: Chronic Activation Of Responder T Cellsmentioning

confidence: 67%

Section: Chronic Activation Of Responder T Cellsmentioning

confidence: 99%

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Silica exposure and altered regulation of autoimmunity

Lee

Matsuzaki

Kumagai-Τakei

et al. 2014

Environ Health Prev Med

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“…2a). In addition, soluble IL-2 receptor (sIL-2R) was elevated in SIL serum when compared with that in HV [43]. Experimentally, silica particles activated freshly isolated peripheral T cells derived from HV monitored by the expression of CD69 on the surface [44].…”

Section: Effects On Nk Cellsmentioning

confidence: 99%

Environmental factors and human health: fibrous and particulate substance-induced immunological disorders and construction of a health-promoting living environment

Otsuki

Matsuzaki

Lee

et al. 2015

Environ Health Prev Med

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Among the various scientific fields covered in the area of hygiene such as environmental medicine, epidemiology, public health and preventive medicine, we are investigating the immunological effects of fibrous and particulate substances in the environment and work surroundings, such as asbestos fibers and silica particles. In addition to these studies, we have attempted to construct health-promoting living conditions. Thus, in this review we will summarize our investigations regarding the (1) immunological effects of asbestos fibers, (2) immunological effects of silica particles, and (

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“…There is a known association between inhalational silica exposure and SSc and an entity linking SSc with exposure to silica particles, with or without the development of silicosis, is called the Erasmus syndrome [40]. Patients with silicosis in general are also noted to have alterations in immunity, with a recent article noting alterations in soluble interleukin 2 (sIL2) receptors in these patients [41]. The mechanisms for the biological effects of silica are still not fully understood.…”

Section: Pneumoconiosis (Silicosis)mentioning

confidence: 99%

Scleroderma Lung Disease – Other Lung Complications in Systemic Sclerosis

Almeida¹

2012

Rheumatology

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Scleroderma or systemic sclerosis (SSc) is a clinically heterogeneous, multi-system autoimmune disorder characterized by endothelial dysfunction, dysregulation of fibroblasts resulting in excessive production of collagen and profound abnormalities of the immune system. Pulmonary involvement is common and occurs in all SSc subsets, including limited cutaneous systemic sclerosis, diffuse cutaneous systemic sclerosis and SSC sine scleroderma. Aside from the common complications of pulmonary vasculopathy and interstitial lung disease (ILD], other less frequent pulmonary complications have been reported in SSc. The emphasis of this review will be on other lung complications in systemic sclerosis.

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Soluble Interleukin-2 Receptor as an Indicator of Immunological Disturbance Found in Silicosis Patients

Cited by 31 publications

References 29 publications

Silica exposure and altered regulation of autoimmunity

Silica exposure and altered regulation of autoimmunity

Environmental factors and human health: fibrous and particulate substance-induced immunological disorders and construction of a health-promoting living environment

Scleroderma Lung Disease – Other Lung Complications in Systemic Sclerosis

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