Soluble intercellular adhesion molecule-1 is related to endothelial vasodilatory function in healthy individuals

Holmlund, Anders; Hulthe, Johannes; Millgård, Jonas; Sarabi, Mahziar; Kahan, Thomas; Lind, Lars

doi:10.1016/s0021-9150(02)00234-4

Cited by 42 publications

(34 citation statements)

References 28 publications

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“…Similarly conflicting results have been published for other hemostatic and inflammatory proteins measured in our study (protein C, factor , thrombomodulin, hsCRP) 10,11,[17][18][19][20][21][22][23][24] . There are, as highlighted in the "Introduction", important differences in the design of our study as compared to the studies mentioned above.…”

Section: Discussioncontrasting

confidence: 73%

Fibrinogen Promotes Early Atherosclerotic Changes of the Carotid Artery in Young, Healthy Adults

Grebe

Luu

Sedding

et al. 2010

JAT

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Aim: To determine whether high plasma levels or activities of different hemostatic proteins contribute to the development of early atherosclerotic vessel wall changes. Elevated levels of various hemostatic proteins and markers of inflammation have been linked to an increased risk of ischemic cardiovascular events; however, the mechanisms by which these molecules might contribute to this increased risk is not clear. Methods:The intima-media thickness of the common carotid arteries (CCA-IMT) of 125 healthy young volunteers without known cardiovascular risk factors was measured by high-resolution ultrasound. Plasma concentrations of fibrinogen, thrombomodulin, protein Z and CRP were quantified, and the plasma activities of protein C, plasminogen and factor were measured. Other established risk factors, such as body mass index (BMI) and plasma levels of cholesterol, triglycerides and homocysteine, were also determined. Furthermore, the carotid arteries were examined for the presence of plaques and stenoses. Results: Univariate analysis showed a significant negative correlation between CCA-IMT and HDL cholesterol, and positive correlations with age, BMI, LDL cholesterol, triglycerides, homocysteine, fibrinogen and thrombomodulin, but not with total cholesterol, lipoprotein(a) and hsCRP. CCA-IMT was also statistically independent of the activities of protein C, factor and plasminogen. Multivariate analysis revealed a significant correlation of CCA-IMT with age, BMI and fibrinogen. Conclusion: Our data suggest that fibrinogen levels correlate with early atherosclerotic changes of the carotid artery in a population with very low cardiovascular risk.

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Section: Discussioncontrasting

confidence: 73%

Fibrinogen Promotes Early Atherosclerotic Changes of the Carotid Artery in Young, Healthy Adults

Grebe

Luu

Sedding

et al. 2010

JAT

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“…Although many prior studies suggest an association of endothelial dysfunction with risk of type 2 diabetes, the data are limited by cross-sectional study designs or limited ability to fully control for confounding factors (8 -18). The present data build on prior data to demonstrate that elevated levels of these biomarkers of endothelial dysfunction are significant, independent precursors of type 2 diabetes in the community Endothelial dysfunction reflects an imbalance in the regulatory function of vascular endothelial cells and is characterized by impaired endothelium-dependent nitric oxide-mediated vasodilatation (28), elevated plasma levels of cellular adhesion molecules (11,29), microalbuminuria (30), and impaired fibrinolysis, marked by elevated plasma levels of PAI-1 and vWF (31). The primary physiologic function of PAI-1 and vWF is to maintain hemostatic balance in the vasculature (32,33), but because the endothelium is a primary source of PAI-1 and vWF, elevated levels also reflect stimulation or injury of endothelial cells (32,34).…”

Section: Diabetes Vol 55 February 2006supporting

confidence: 61%

“…The primary physiologic function of PAI-1 and vWF is to maintain hemostatic balance in the vasculature (32,33), but because the endothelium is a primary source of PAI-1 and vWF, elevated levels also reflect stimulation or injury of endothelial cells (32,34). Elevated plasma levels of biomarkers of endothelial dysfunction are modestly correlated with impaired endothelium-dependent vasodilatation in forearm skin or the brachial artery (11,29) and are highly correlated with insulin resistance (12,35,36), providing one mechanism by which endothelial dysfunction might confer risk for type 2 diabetes. In the arteriolar microcirculation, impaired endothelium-dependent vasomotion may limit insulin-mediated capillary recruitment and redistribution of skeletal muscle blood flow from nonnutritive to nutritive flow routes, diminishing insulin delivery to insulin-sensitive muscle tissue (6,(37)(38)(39).…”

Section: Diabetes Vol 55 February 2006mentioning

confidence: 99%

Hemostatic Markers of Endothelial Dysfunction and Risk of Incident Type 2 Diabetes

et al. 2006

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Endothelial dysfunction may precede development of type 2 diabetes. We tested the hypothesis that elevated levels of hemostatic markers of endothelial dysfunction, plasminogen activator inhibitor-1 (PAI-1) antigen, and von Willebrand factor (vWF) antigen predicted incident diabetes independent of other diabetes risk factors. We followed 2,924 Framingham Offspring subjects (54% women, mean age 54 years) without diabetes at baseline (defined by treatment, fasting plasma glucose >7 or 2-h postchallenge glucose >11.1 mmol/l) over 7 years for new cases of diabetes (treatment or fasting plasma glucose >7.0 mmol/ l). We used a series of regression models to estimate relative risks for diabetes per interquartile range (IQR) increase in PAI-1 (IQR 16.8 ng/ml) and vWF (IQR 66.8% of control) conditioned on baseline characteristics. Over follow-up, there were 153 new cases of diabetes. Age-and sex-adjusted relative risks of diabetes were 1.55 per IQR for PAI-1 (95% CI 1.41-1.70) and 1.49 for vWF (1.21-1.85). These effects remained after further adjustment for diabetes risk factors (including physical activity; HDL cholesterol, triglyceride, and blood pressure levels; smoking; parental history of diabetes; use of alcohol, nonsteroidal anti-inflammatory drugs, exogenous estrogen, or hypertension therapy; and impaired glucose tolerance), waist circumference, homeostasis model assessment of insulin resistance, and inflammation (assessed by levels of C-reactive protein): the adjusted relative risks were 1.18 per IQR for PAI-1 (1.01-1.37) and 1.39 for vWF (1.09 -1.77). We conclude that in this community-based sample, plasma markers of endothelial dysfunction increased risk of incident diabetes independent of other diabetes risk factors including obesity, insulin resistance, and inflammation. Diabetes 55:530 -537, 2006

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“…An increase in severity (stage) of hypertension was not associated with a change in the expression of the 2 CAMs. This observation is, at least in part, consistent with those in the study by Preston et al,31 in which the strong positive correlation between slCAM-1, sVCAM-1, and vWF levels versus BP in patients with normotension or mild hypertension was not found in patients with severe hypertension (mean SBP/DBP, 195 [26]/127 [7] mm Hg). The mechanisms by which systemic hypertension leads to an increase in levels of particular CAMs is not fully understood.…”

Section: Discussionsupporting

confidence: 91%

“…[14][15][16][17][18][19] However, controversy exists as to whether individuals with hypertension without other risk factors for atherosclerosis have elevated levels of CAMs. 16,[20][21][22][23][24] Moreover, even in population-based studies, the relationships between CAMs and blood pressure (BP) are inconsistent) 9, [25][26][27] The aim of this study was to determine whether (1) levels of sCAMs (sE-selectin, slCAM-1, sVCAM-1, and von Willebrand factor [vWF]) are elevated in Taiwanese adults with uncomplicated essential hypertension without other risk factors; (2) CAM levels increase with severity (stage) of hypertension; and (3) monotherapy with the angiotensin II-receptor blocker (ARB) irbesartan modulates CAM expression in a subgroup of these patients.…”

Section: Introductionmentioning

confidence: 99%

Effects of angiotensin II-receptor blockers on soluble cell adhesion molecule levels in uncomplicated systemic hypertension: An observational, controlled pilot study in Taiwanese adults

HWANG

TSAI²,

LU³

et al. 2005

Current Therapeutic Research

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Background: Controversy exists as to whether individuals with hypertension without risk factors for atherosclerosis (eg, diabetes mellitus, dyslipidemia, obesity) have elevated levels of cell adhesion molecules (CAMs).Objective: The aim of this study was to determine whether (1) levels of sol- (63) mg. Hypertensive patients had significantly higher circulating levels of sICAM-1 compared with normotensive controls (P --0.009). No significant differences in levels of sVCAM-1, sE-selectin, or vWF were found between hypertensive patients and controls. The mean slCAM-1 level was significantly higher in the prehypertensive patients compared with normotensive controls (P--0.03). The mean sE-selectin level was significantly higher in the patients with stage I hypertension compared with the prehypertensive group (P = 0.01). The 18 patients given 8 weeks of irbesartan monotherapy showed a significant decrease from baseline in systolic and diastolic BP (both, P--0.001) and sE-selectin (P = 0.006), but not in sVCAM-1 or sICAM. Fortythree patients did not reach target BP on irbesartan monotherapy and thus were treated with combination therapy. Conclusions:Based on the results of this observational, controlled pilot study in Taiwanese patients, we suggest that ARB therapy, in addition to reducing BP, has the potential to suppress CAM expression and to improve endothelial dysfunction in hypertension. (Curr Ther Res Clin Exp. 2005;66:181-194) Copyright

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Soluble intercellular adhesion molecule-1 is related to endothelial vasodilatory function in healthy individuals

Cited by 42 publications

References 28 publications

Fibrinogen Promotes Early Atherosclerotic Changes of the Carotid Artery in Young, Healthy Adults

Fibrinogen Promotes Early Atherosclerotic Changes of the Carotid Artery in Young, Healthy Adults

Hemostatic Markers of Endothelial Dysfunction and Risk of Incident Type 2 Diabetes

Effects of angiotensin II-receptor blockers on soluble cell adhesion molecule levels in uncomplicated systemic hypertension: An observational, controlled pilot study in Taiwanese adults

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