Soluble HLA:

McDonald, John C.; Adamashvili, Irena

doi:10.1016/s0198-8859(98)00033-0

Cited by 38 publications

(1 citation statement)

References 176 publications

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“…Soluble HLA-A, B and C (sHLA-I) antigens occur naturally in body fluid and their levels can increase in circumstances characterized by T cell activation such as viral infections, chronic renal diseases, liver and bone marrow transplants or can be found at decreased levels in patients with solid tumors [95]. Cells expressing HLA-I were found in active inflammatory MS lesions and increased sHLA-I levels were detected in CSF and serum of MS patients.…”

Section: Soluble Hla Moleculesmentioning

confidence: 99%

Biological Markers for Multiple Sclerosis

Lutterotti¹,

Berger²,

Reindl

2007

CMC

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Multiple sclerosis (MS) is the most common disabling neurological disease in young adults and is thought to result from an autoimmune attack against autoantigens within the myelin sheath. A characteristic feature of MS is the broad heterogeneity of clinical, histopathological and immunological phenotypes, which urges a more differentiated defining of patients by biological markers that reflect the underlying disease process and allow the prediction of disease courses and treatment responses. Here we review the current research on the identification of biomarkers for MS in cerebrospinal fluid and/or blood. We will focus on antibodies to myelin and non-myelin antigens, cells and soluble molecules of the immune system and the brain as biomarkers for 1) the diagnosis and prediction of clinical courses, 2) disease activity and 3) treatment response in MS.

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Section: Soluble Hla Moleculesmentioning

confidence: 99%

Biological Markers for Multiple Sclerosis

Lutterotti¹,

Berger²,

Reindl

2007

CMC

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Comparative analysis of serum proteomes of degenerative scoliosis

Zhu

Han

Zhao

et al. 2011

Journal Orthopaedic Research

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Degenerative scoliosis (DS) is an important degenerative lumbar disease causing spinal dysfunction and affecting the quality of life of the elderly, and is associated not only with severe back or leg pain but also with complicated surgical outcomes. The pathogenesis of DS is still unknown. Therefore, it is very important to ascertain the etiology of degenerative scoliosis and establish related molecular markers predicting and controlling the scoliosis. For the first time, we used two-dimensional fluorescence DIGE to compare the serum proteome profiles of 12 DS patients and controls. Proteins found to be differentially expressed were identified by MALDI-TOF mass spectrometric analysis, coupled with database interrogation. Eleven spots that were differentially expressed in the sera of DS patients were found, and eight gene products were identified among these spots. Clusterin, CLU cDNA FLJ57622, ALB cDNA FLJ50830, Hypothetical short protein, HLA-A MHC class 1 antigen. (Fragment), ALB 23 kDa protein, Isoform 1 of G proteinregulated inducer of neurite outgrowth 1 (GPRIN I)and Ficolin-3 were down-regulated in the sera of DS patients. The decreased levels of Clusterin and Ficolin-3 were confirmed by Western blot. The information obtained with this proteomic analysis will be very useful in understanding the pathophysiology of DS as well as in finding candidates as drug targets of DS. These results may provide a novel approach for the pathogenesis study of DS. Keywords: degenerative; scoliosis; serum; DIGE; proteomics Degenerative scoliosis (DS) refers to scoliotic curves developing after skeletal maturity without previous history of scoliosis. Scoliosis occurs de novo in later life and is associated not only with deformity but also with severe back or leg pain.1 With the lifestyle changes of the elderly, DS has become an important degenerative lumbar disease causing spinal dysfunction and affecting quality of life of the elderly.The pathogenesis of DS is still unknown. Osteoporosis has long been implicated in the pathogenesis of elderly patients with DS. Vanderpool et al.2 found scoliosis in 36% of osteoporotics compared to 6% in age-matched normals. However, Robin et al.3 were unable to find a significant correlation between scoliosis and osteoporosis.Although osteoporosis, asymmetric degenerative disc disease, facet tropism and inheritance have been implicated as factors in the development of DS, none has been shown to be directly related. Most of the current research on the DS is about the treatment of this disease, and the basic research on the etiology is few. Furthermore, there was no molecular biology study reported. Therefore, It is very important to ascertain the etiology of DS and establish related molecular markers predicting and controlling the scoliosis. Proteomics analysis is currently considered to be a powerful tool for global evaluation of protein expression, and proteomics has been widely applied in analysis of diseases, especially in fields of cancer research. Two-dimensional (2D) gel elect...

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