Soluble Form of Receptor for Advanced Glycation End Products Is Associated with Obesity and Metabolic Syndrome in Adolescents

He, Chih-Tsueng; Lee, Chien-Hsing; Hsieh, Chang‐Hsun; Hsiao, Fone-Ching; Kuo, Philip; Chu, Nain-Feng; Hung, Yi‐Jen

doi:10.1155/2014/657607

Cited by 39 publications

(35 citation statements)

References 26 publications

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“…even if not accompanied by additional cardiometabolic risk factors such as elevated BP, AIP, and IR, associates with low sRAGE and esRAGE levels. In contrast with our hypothesis, the missing association between sRAGE and/or esRAGE and measures of obesity in some but not all studies [13][14][15][16][17][18][19][20][21][22][39][40][41][42][43] might not be related to the metabolically healthy obese phenotype. Since in non-diabetic adults low sRAGE levels associate independently with a future risk of cardiometabolic diseases and mortality [24], we might presume that a metabolically healthy obese phenotype is far from being a benign condition [44,45].…”

Section: Discussioncontrasting

confidence: 99%

“…It is presumed that sRAGE levels reflect tissue RAGE expression [12]. However, the majority [13][14][15][16][17][18][19][20], but not all [21][22][23], studies in non-diabetic individuals report lower sRAGE and/or esRAGE levels in obese vs. lean subjects, and/or an inverse relationship between measures of obesity and circulating receptor levels. Reasons underlying these inconsistencies remain unclear but are intriguing in view of the observations that in non-diabetics low sRAGE levels associate with an increased risk of development of metabolic syndrome, diabetes, cardiovascular disease, or death [18,[24][25][26].…”

Section: Introductionmentioning

confidence: 99%

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Correlation among soluble receptors for advanced glycation end-products, soluble vascular adhesion protein-1/semicarbazide-sensitive amine oxidase (sVAP-1) and cardiometabolic risk markers in apparently healthy adolescents: a cross-sectional study

et al. 2016

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In non-diabetics, low levels of soluble receptor for advanced glycations end products (sRAGE) associate with an increased risk of development of diabetes, cardiovascular afflictions, or death. The majority of studies in non-diabetics report an inverse relationship between measures of obesity, cardiometabolic risk factors and sRAGE and/or endogenous secretory RAGE (esRAGE) levels. To elucidate whether this inconsistency is related to the metabolically healthy obese phenotype, or a different impact of the risk factors in presence and absence of obesity, we analyzed data from 2206 apparently healthy adolescents (51 % girls) aged 15-to-19 years. The association of sRAGE levels with soluble vascular adhesion protein-1/semicarbazide sensitive amine oxidase (sVAP-1/SSAO) was also investigated. Centrally obese, including metabolically healthy, adolescents present significantly lower sRAGE and esRAGE, but not sVAP-1, levels in comparison with their lean counterparts. An increasing number of cardiometabolic risk factors did not associate with significant changes in sRAGE, esRAGE or sVAP-1 levels either in lean or in obese subjects. In multivariate analyses, WHtR, hsCRP, markers of glucose homeostasis, renal function, adiponectin, and sVAP-1 associated significantly with sRAGE and esRAGE. SVAP-1 correlated significantly with glycemia, adiponectin, hsCRP, and sRAGE. Thus, in adolescents, a decline in sRAGE and esRAGE precedes the development of metabolic syndrome. When combined, standard and non-standard cardiometabolic risk factors explain only minor proportion in a variability of sRAGE and esRAGE (8 %-11 %); or sVAP-1 (12 %-20 %). Elucidation of pathogenetic mechanisms underlying early decline in sRAGE and esRAGE levels in obese adolescents and their clinical impact with regard to future cardiometabolic health requires further studies.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Correlation among soluble receptors for advanced glycation end-products, soluble vascular adhesion protein-1/semicarbazide-sensitive amine oxidase (sVAP-1) and cardiometabolic risk markers in apparently healthy adolescents: a cross-sectional study

et al. 2016

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“…[29,30], insulin resistance [7,31], diabetes mellitus [8,11], increased oxidative stress [32,33], inflammatory reactions [34,35] as well as mutations on genetic levels [36][37][38], of which the risks rise proportionally associated with MSC.…”

Section: Resultsmentioning

confidence: 99%

Utilizing the metabolic syndrome component count in workers’ health surveillance: An example of day-time vs. day-night rotating shift workers

Lin¹,

Hsieh²,

Chen³

2015

Int J Occup Med Environ Health

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Objectives: To establish a practical method for assessing the general metabolic health conditions among different employee groups, this study utilized the total count of metabolic syndrome (MetS) elements as a parameter, and performed a retrospective analysis comparing changes of MetS component count (MSC) of 5 years among day-time work (DW) and day-andnight rotating shift work (RSW) employees. Material and Methods: The data of personal histories, physical examinations, blood tests, abdominal sonographic examinations and occupational records were collected from a cohort of workers in an electronics manufacturing company. We first defined the arithmetic mean value of MSC as MSC density (MSCD) for the employee group; then we compared the changes of MSCD over 5 years between DW and RSW workers. Occupational, personal and health records were analyzed for the 1077 workers with an initial mean age of 32.4 years (standard deviation (SD): 6.2 years), including 565 RSW workers (52%). Results: The initial MSCDs were 1.26 and 1.12 (p = 0.06) for DW and RSW workers, respectively; after 5 years, the increments of MSCD for DW and RSW workers were 0.10 and 0.39, respectively (p < 0.01). By performing multivariate logistic regression analyses, and comparing with DW co-workers, final results indicated that the workers exposed to RSW have 1.7-fold increased risk of elevated MSCD (95% confidence interval (CI): 1.28-2.25, p < 0.01); and are 38% less likely (adjusted rate ratio (aRR) 0.62, 95% CI: 0.45-0.86, p < 0.01) to attain decreased MSCD. Conclusions: These observations demonstrate that changes of MSCD are significantly different between DW and RSW workers, and are increasingly associated with RSW exposure. In conclusion, MSCD can represent the general metabolic health conditions of a given employee group; MSC, MSCD and their transitional changes can be applied as simple and standardized tools for monitoring metabolic health risk profiles when managing employee health, at both the individual and company levels.

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“…We found the mean sRAGE concentrations in the control group were more than double the concentrations in PCOS patients, so the difference might be more pronounced between PCOS patients and non-tubal factor patients. sRAGE decreased in women with a BMI of greater than 25 [17], so only patients with BMIs ≤25 were included. As there is a documented negative correlation between the sRAGE levels and BMI [22], sRAGE might be lower in the obese PCOS patients.…”

Section: Discussionmentioning

confidence: 99%

“…The cycle determinants included age, FSH/LH, body mass index (BMI), total gonadotropin (Gn) dose in international units used per cycle, the number of days of stimulation, the number of oocytes retrieved, the rate of high-quality embryos, and the normal fertilization rate. sRAGE decreases in women older than 35 years old and women with BMIs >25 [17]; thus, only patients <35 years old with BMIs ≥18 and ≤25 were included. The general data in the two groups are shown in Table 1.…”

Section: Subjectsmentioning

confidence: 99%

Follicular fluid soluble receptor for advanced glycation endproducts (sRAGE): a potential protective role in polycystic ovary syndrome

Asan

Hao

Yang

et al. 2016

J Assist Reprod Genet

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Purpose To explore the relationships between the soluble receptor for advanced glycation endproducts (sRAGE) and the outcome parameters following in vitro fertilization-embryo transfer (IVF-ET) in patients with polycystic ovary syndrome (PCOS) and investigate the protective effect of sRAGE in PCOS development regarding inflammation. Methods We conducted a prospective analysis of a subsample of 74 participants from the Reproductive Medical Center of the First Affiliated Hospital of Zhengzhou University. We quantified sRAGE, vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF-α), interleukelin-6 (IL-6), and C-reactive protein (CPR) protein levels in the follicular fluid from 39 PCOS and 35 non-PCOS reproductive-age women. sRAGE and VEGF, TNF-α, IL-6, and CRP in follicular fluid aspirated without blood were measured by ELISA. Results sRAGE concentrations in the follicular fluid were significantly lower in the PCOS group compared to those in the control group, while VEGF, TNF-α, IL-6, and CRP concentrations were significantly higher in the PCOS group than in the control group (P < 0.05). sRAGE was significantly, inversely correlated with the total dose of gonadotropin (Gn) in the PCOS group undergoing IVF treatment (r = −0.451, P = 0.004). After adjusting for age and Gn dose (in international units used per cycle), sRAGE protein levels in the follicular fluid were significantly, inversely related to VEGF (r = −0.378, P = 0.018), TNF-α (r = −0.450, P = 0.004), IL-6 (r = −0.455, P = 0.004), and CRP (r = −0.375, P = 0.019). Conclusion sRAGE in the follicular fluid might exert a protective effect against the inflammatory action of PCOS development.

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Soluble Form of Receptor for Advanced Glycation End Products Is Associated with Obesity and Metabolic Syndrome in Adolescents

Cited by 39 publications

References 26 publications

Correlation among soluble receptors for advanced glycation end-products, soluble vascular adhesion protein-1/semicarbazide-sensitive amine oxidase (sVAP-1) and cardiometabolic risk markers in apparently healthy adolescents: a cross-sectional study

Correlation among soluble receptors for advanced glycation end-products, soluble vascular adhesion protein-1/semicarbazide-sensitive amine oxidase (sVAP-1) and cardiometabolic risk markers in apparently healthy adolescents: a cross-sectional study

Utilizing the metabolic syndrome component count in workers’ health surveillance: An example of day-time vs. day-night rotating shift workers

Follicular fluid soluble receptor for advanced glycation endproducts (sRAGE): a potential protective role in polycystic ovary syndrome

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