Soluble FMDV VP1 proteins fused with calreticulin expressed in Escherichia coli under the assist of trigger factor16 (Tf16) formed into high immunogenic polymers

Liu, Chang; Feng, Hao; Liu, Yunchao; Chen, Yumei; Yang, Suzhen; Deng, Ruiguang; Zhang, Gaiping

doi:10.1016/j.ijbiomac.2019.11.130

Cited by 5 publications

(1 citation statement)

References 29 publications

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“…VP1 and VP3 play important roles in inhibiting the production of host interferons to weaken the host antiviral response. On the other hand, VP2 is involved in the induction of autophagy ( Feng et al, 2018 ; Li et al, 2019b ; Liu et al, 2020 ).…”

Section: Fmdv Proteins Regulate Host Innate Immunitymentioning

confidence: 99%

Advances in Foot-and-Mouth Disease Virus Proteins Regulating Host Innate Immunity

Peng

Yang

et al. 2020

Front. Microbiol.

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Foot-and-mouth disease (FMD) is a highly contagious disease that affects cloven-hoofed animals such as pigs, cattle, and sheep. The disease is caused by the foot-and-mouth disease virus (FMDV) which has a non-enveloped virion with icosahedral symmetry that encapsulates a positive-sense, single-stranded RNA genome of ∼8.4 kb. FMDV infection causes obvious immunosuppressive effects on the host. In recent years, studies on the immunosuppressive mechanism of FMDV have become a popular topic. In addition, studies have shown that many FMDV proteins are involved in the regulation of host innate immunity and have revealed mechanisms by which FMDV proteins mediate host innate immunity. In this review, advances in studies on the mechanisms of interaction between FMDV proteins and host innate immunity are summarized to provide a comprehensive understanding of FMDV pathogenesis and the theoretical basis for FMD prevention and control.

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Section: Fmdv Proteins Regulate Host Innate Immunitymentioning

confidence: 99%