Soluble fibre (Plantago ovata husk) reduces plasma low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, oxidised LDL and systolic blood pressure in hypercholesterolaemic patients: A randomised trial

Solà, Rosa; Bruckert, Éric; Valls, Rosa M.; Narejos, Silvia; Luque, Xavier; Castro-Cabezas, Manuel; Doménech, Gema; Torres, Ferrán; Heras, Mercedes; Farrés, Xavier; Vaquer, José-Vicente; Martínez, J Fausto Bustamante; Almaraz, María Cruz; Anguera, Anna

doi:10.1016/j.atherosclerosis.2010.03.010

Cited by 76 publications

(47 citation statements)

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“…Baseline variables of patients assigned to the placebo and Po-husk groups and treatment differences between groups in CVD biomarkers presented values with the same trend as those obtained in the previous study (Solà et al 2010). Table 3 shows polymorphisms associated with the baseline variables.…”

Section: Resultssupporting

confidence: 63%

“…This trial was registered with CinicalTrials.gov, number NCT00502047, and EudraCT No. year-2004-002184-24. Biological samples and measurements Details of the blood collection and biomarker measurements have been published (Solà et al 2010) and will be presented briefly here. A fasting blood sample was taken at baseline and at week 8 to measure safety and efficacy data.…”

Section: Study Design and Populationmentioning

confidence: 99%

“…The population studied was selected from a previous study (Solà et al 2010). The study design and population have previously been described (Solà et al 2010).…”

Section: Study Design and Populationmentioning

confidence: 99%

“…The study design and population have previously been described (Solà et al 2010). Briefly, the two-arm study was a phase IV-II, multi-centred, randomised, double-blind, placebo-controlled analysis of the effect of Po-husk on hypercholesterolaemia.…”

Section: Study Design and Populationmentioning

confidence: 99%

“…Moreover, it has been shown that soluble fibre is more effective in lowering blood cholesterol and LDL-C concentrations than insoluble fibre (Brown et al 1999;Vuksan et al 2011;Fernandez 2001;Jenkins et al 2000;Solà et al 2007). Soluble fibre has also been shown to reduce other CVD risk biomarkers such as triglyceridaemia (Solà et al 2010;Galisteo et al 2010), blood glucose levels (Ziai et al 2005;Sierra et al 2002), arterial hypertension (He et al 2004;Galisteo et al 2005) and systolic blood pressure (Solà et al 2010).…”

Section: Introductionmentioning

confidence: 99%

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Polymorphisms in LEP and NPY genes modify the response to soluble fibre Plantago ovata husk intake on cardiovascular risk biomarkers

et al. 2012

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The satiating effect of fibre consumption has been related to gut hormones, such as peptide YY and leptin. These peptides may also influence cardiovascular (CVD) risk biomarkers. Nevertheless, there is wide interindividual variation in metabolic responses to fibre consumption. The objective was to investigate differences in the effects of soluble fibre, in the form of Plantago ovata husk (Po-husk) treatment, on CVD risk biomarkers according to selected polymorphisms in genes related to satiety. The study was a multi-centred, double-blind, placebo-controlled, parallel and randomised trial in mildmoderate hypercholesterolaemic patients (age range: 43-67 years). Eight polymorphisms in three genes related to satiety (LEP, NPY and PYY) were identified in 178 participants; 88 patients in the placebo (microcrystalline cellulose 14 g/day) group and 90 in the Po-husk (14 g/day) group, which had added to a low-saturated-fat diet for 8 weeks. The CVD biomarkers measured included the following: lipid profile, blood pressure (BP), glucose, insulin, hs-CRP, oxidised LDL and IL-6. Relative to the placebo, Po-husk consumption lowered the plasma total cholesterol concentration by 3.3 % according to rs7799039 polymorphism in the LEP gene (p \ 0.05). Furthermore, the Po-husk reduced systolic BP (mean [95 % CI]) by -8 mmHg (-14.16; -1.90) and hs-CRP by 24.9 % in subjects with the AA genotype of the rs16147 polymorphism in the NPY gene (32 % of our total population; p \ 0.05), which remained significant after Bonferroni correction. In conclusion, polymorphisms in the LEP and NPY genes potentiate the response to Po-husk, particularly the effects on systolic BP and the hs-CRP plasma concentration.

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Section: Resultssupporting

confidence: 63%

Section: Study Design and Populationmentioning

confidence: 99%

“…The population studied was selected from a previous study (Solà et al 2010). The study design and population have previously been described (Solà et al 2010).…”

Section: Study Design and Populationmentioning

confidence: 99%

Section: Study Design and Populationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Polymorphisms in LEP and NPY genes modify the response to soluble fibre Plantago ovata husk intake on cardiovascular risk biomarkers

et al. 2012

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Higher dietary fibre intake is associated with increased skeletal muscle mass and strength in adults aged 40 years and older

Frampton

Murphy

Frost

et al. 2021

J cachexia sarcopenia muscle

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Background Skeletal muscle mass begins to decline from 40 years of age. Limited data suggest that dietary fibre may modify lean body mass (BM), of which skeletal muscle is the largest and most malleable component. We investigated the relationship between dietary fibre intake, skeletal muscle mass and associated metabolic and functional parameters in adults aged 40 years and older. Methods We analysed cross‐sectional data from the US National Health and Nutrition Examination Survey between 2011 and 2018 from adults aged 40 years and older. Covariate‐adjusted multiple linear regression analyses were used to evaluate the association between dietary fibre intake and BM components (BM, body mass index [BMI], total lean mass, appendicular lean mass, bone mineral content, total fat, trunk fat; n = 6454), glucose homeostasis (fasting glucose, fasting insulin, HOMA2‐IR; n = 5032) and skeletal muscle strength (combined grip strength; n = 5326). BM components and skeletal muscle strength were expressed relative to BM (per kg of BM). Results Higher intakes of dietary fibre were significantly associated with increased relative total lean mass (β: 0.69 g/kg BM; 95% CI, 0.48–0.89 g/kg BM; P < 0.001), relative appendicular lean mass (β: 0.34 g/kg BM; 95% CI, 0.23–0.45 g/kg BM; P < 0.001), relative bone mineral content (β: 0.05 g/kg BM; 95% CI, 0.02–0.07 g/kg BM; P < 0.001) and relative combined grip strength (β: 0.002 kg/kg BM; 95% CI, 0.001–0.003 kg/kg BM; P < 0.001). Conversely, higher dietary fibre intakes were significantly associated with a lower BM (β: −0.20; 95% CI, −0.28 to −0.11 kg; P < 0.001), BMI (β: −0.08 kg/m2; 95%CI, −0.10 to −0.05 kg/m2), relative total fat (β: −0.68 g/kg BM; 95% CI, −0.89 to −0.47 g/kg BM; P < 0.001), relative trunk fat (β: −0.48 g/kg BM; 95%CI, −0.63 to −0.33 g/kg; P < 0.001), fasting glucose (β: −0.01 mmol/L; 95% CI, −0.02 to −0.00 mmol/L; P = 0.017), fasting insulin (β: −0.71 pmol/L; 95% CI, −1.01 to −0.41 pmol/L; P < 0.001) and HOMA2‐IR (β: −0.02 AU; 95% CI, −0.02 to −0.01 AU; P < 0.001). Conclusions Higher dietary fibre intakes are associated with a lower BM and enhanced body composition, characterized by a reduction in fat mass and an increase in lean mass. Higher dietary fibre intakes were also associated with improvements in glucose homeostasis and skeletal muscle strength. Increasing dietary fibre intake may be a viable strategy to prevent age‐associated declines in skeletal muscle mass.

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Gallic Acid Improves Health‐Associated Biochemical Parameters and Prevents Oxidative Damage of DNA in Type 2 Diabetes Patients: Results of a Placebo‐Controlled Pilot Study

Ferk

Kundi

Brath³

et al. 2018

Molecular Nutrition Food Res

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Soluble fibre (Plantago ovata husk) reduces plasma low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, oxidised LDL and systolic blood pressure in hypercholesterolaemic patients: A randomised trial

Cited by 76 publications

References 23 publications

Polymorphisms in LEP and NPY genes modify the response to soluble fibre Plantago ovata husk intake on cardiovascular risk biomarkers

Polymorphisms in LEP and NPY genes modify the response to soluble fibre Plantago ovata husk intake on cardiovascular risk biomarkers

Higher dietary fibre intake is associated with increased skeletal muscle mass and strength in adults aged 40 years and older

Gallic Acid Improves Health‐Associated Biochemical Parameters and Prevents Oxidative Damage of DNA in Type 2 Diabetes Patients: Results of a Placebo‐Controlled Pilot Study

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