Soluble Fas/FasL ratio as a marker of vasculopathy in children and adolescents with sickle cell disease

Adly, Amira Abdel Moneam; Ismail, Eman Abdel Rahman; Andrawes, Nevine G.; Mahmoud, Mai M.; Eladawy, Rasha

doi:10.1016/j.cyto.2015.12.022

Cited by 13 publications

(22 citation statements)

References 59 publications

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“…Therefore, the prognostic value of microalbuminuria in pediatric patients with SCD remains to be established. Newer serum and urinary biomarkers, such as soluble Fas/Fas‐ligand ratio or serum FMS‐like tyrosine kinase‐1 (sFLT‐1), are now being studied as surrogate measures of early renal involvement in SCD . However, as yet, none of these clinical markers has consistently and sensitively identified the complex processes underlying the development of CKD in patients with SCD.…”

Section: Introductionmentioning

confidence: 99%

Diffusion tensor imaging MRI of sickle cell kidney disease: initial results and comparison with iron deposition

Donnola

Piccone

et al. 2018

NMR in Biomedicine

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Chronic kidney disease (CKD) occurs in over one-third of patients with sickle cell disease (SCD) and can progress to end-stage renal disease. Unfortunately, current clinical assessments of kidney function are insensitive to early-stage CKD. Previous studies have shown that diffusion magnetic resonance imaging (MRI) can sensitively detect regional renal microstructural changes associated with early-stage CKD. However, previous MRI studies in patients with SCD have been largely limited to the detection of renal iron deposition assessed by T * relaxometry. In this pilot imaging study, we compare MRI assessments of renal microstructure (diffusion) and iron deposition (T *) in patients with SCD and in non-SCD control subjects. Diffusion tensor imaging (DTI) and T * relaxometry MRI data were obtained for pediatric (n = 5) and adult (n = 4) patients with SCD, as well as for non-SCD control subjects (n = 10), on a Siemens Espree 1.5-T MRI scanner. A region-of-interest analysis was used to calculate mean medullary and cortical values for each MRI metric. MRI findings were also compared with clinical assessments of renal function and hemolysis. Patients with SCD showed a significant decrease in medullary fractional anisotropy (FA, p = 0.0001) in comparison with non-SCD subjects, indicative of microstructural alterations in the renal medulla of patients with SCD. Cortical and medullary reductions in T * (increased iron deposition, p = ≤0.0001) were also observed. Significant correlations were also observed between kidney T * assessments and multiple measures of hemolysis. This is the first DTI MRI study of patients with SCD to demonstrate reductions in medullary FA despite no overt CKD [estimated glomerular filtration rate (eGFR) > 100 mL/min/1.73 m ]. These medullary FA changes are consistent with previous studies in patients with CKD, and suggest that DTI MRI can provide a useful measure of kidney injury to complement MRI assessments of iron deposition.

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Section: Introductionmentioning

confidence: 99%

Diffusion tensor imaging MRI of sickle cell kidney disease: initial results and comparison with iron deposition

Donnola

Piccone

et al. 2018

NMR in Biomedicine

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“…sFas and sFas/sFasL ratio were significantly higher in SCD patients compared with the control group (p < 0.001), whereas the sFasL was significantly lower in patients (p = 0.022). In conclusion of the study, they revealed that the apoptosis biomarkers were significantly higher in patients with pulmonary hypertension or nephropathy [21]. Cardinal et al [22] researched apoptotic sFas levels among patients with chest pain for the diagnostic accuracy of acute coronary syndromes.…”

Section: Discussionmentioning

confidence: 94%

“…İt is known that Fas/FasL is increased to an inflammatory response. Adly et al [21] analysed the sFas and sFasL levels in sickle cell disease. They compared the levels of sFas and sFasL among the patient and control group.…”

Section: Discussionmentioning

confidence: 99%

Apoptosis biomarkers (Apaf-1, sFa s, sFa s-L, and caspase-9), albumin, and fetuin-A levels in pulmonary thromboembolic patients

Aydın

Tekin

Korkmaz

et al. 2020

Disaster Emerg Med J

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INTRODUCTION: Pulmonary thromboembolism (PE) is the third most common medical emergency with mortality due to ischemia and reperfusion lung injury. Lung ischaemia-reperfusion injury. Lung reperfusion damage is believed to cause cellular damage and apoptosis. The aim of the present study was to evaluate the levels of fetuin-A, albumin, and apoptosis biomarkers (Apaf-1, sFas, and sFasL) among pulmonary thromboembolic patients. MATERIAL AND METHODS: Blood samples were collected from 45 volunteer patients and 40 healthy control volunteers. Human apoptosis biomarkers (Apaf-1, sFas, sFasL, and caspase-9) and fetuin-A values were measured by ELISA device. Student's t-test or Mann-Whitney U test were used for continuous variables, and categorical variables were compared with the chi-square test to assess the significance of intergroup differences. The mean values of apoptosis biomarkers and acute phase reactants between dead and survival patients were also compared. RESULTS: While the apoptosis mean values of Apaf-1, sFas, sFasL, and caspase-9 for the control group were

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“…The HC cohort comprised 17 individuals, among whom 88% were female and nearly 30% were of Asian ethnicity. The median (IQR) age was 41 (28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44) years. The HC cohort was gender-matched and ethnicitymatched to the SLE cohort, but was significantly younger (mean (SD) 37.4 (10.2) vs 45.4 (14.2) years; p=0.03).…”

Section: Participant Characteristicsmentioning

confidence: 99%

“…21 The use of this ratio may better reflect the Fas/FasL system biological activity as a whole, where sFas and sFasL may have divergent biological functions. 21 31 While the ratio has been investigated in other conditions, [32][33][34][35] only one prior study in a small cohort of 15 patients assessed this ratio in relation to SLE disease activity. 21 Lupus Science & Medicine B cell-activating factor from the TNF family (BAFF) is a key pathogenic cytokine in SLE.…”

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confidence: 99%

Associations of serum soluble Fas and Fas ligand (FasL) with outcomes in systemic lupus erythematosus

et al. 2020

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ObjectiveFas/Fas ligand (FasL) and B cell-activating factor (BAFF) signalling have pivotal roles in SLE pathogenesis. We investigated the clinical associations of serum concentrations of soluble Fas (sFas) and soluble FasL (sFasL) in SLE and their relationship with BAFF.MethodsSerum sFas and sFasL were quantified by multiplex assay, and BAFF by ELISA, in 118 patients with SLE and 17 healthy controls (HC). SLE disease activity and organ damage were assessed using the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and the Systemic Lupus International Collaborating Clinics Damage Index.ResultssFas, sFasL and BAFF were detectable in all samples. Serum sFas and sFasL were significantly higher in SLE compared with HC. In univariable regression analyses, patients with active renal disease and those with flare had significantly higher levels of sFas compared with those without. High serum BAFF in patients with SLE was associated with increased sFas but not sFasL. The association between sFas and renal disease remained significant after adjusting for BAFF, but the association with flare attenuated. High sFas levels were associated with increased time-adjusted mean SLEDAI-2K, even after adjusting for BAFF, and with higher odds of flare over time. In contrast, high sFasL was associated with reduced organ damage over time. Serum sFasL/sFas ratio was negatively associated with active overall disease, flare and organ damage.ConclusionsSerum sFas is associated with active renal SLE, and active disease and flare over time, while sFasL/sFas ratio is negatively associated with disease activity and organ damage accrual. Treatments correcting abnormal levels of sFas/FasL may be worthy of evaluation in SLE.

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Soluble Fas/FasL ratio as a marker of vasculopathy in children and adolescents with sickle cell disease

Cited by 13 publications

References 59 publications

Diffusion tensor imaging MRI of sickle cell kidney disease: initial results and comparison with iron deposition

Diffusion tensor imaging MRI of sickle cell kidney disease: initial results and comparison with iron deposition

Apoptosis biomarkers (Apaf-1, sFa s, sFa s-L, and caspase-9), albumin, and fetuin-A levels in pulmonary thromboembolic patients

Associations of serum soluble Fas and Fas ligand (FasL) with outcomes in systemic lupus erythematosus

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