Soluble extracts from carioca beans (Phaseolus vulgaris L.) affect the gut microbiota and iron related brush border membrane protein expression in vivo (Gallus gallus)

Dias, Desirrê Morais; Kolba, Nikolai; Hart, Jon J.; Ma, Michelle; Sha, Sybil; Lakshmanan, Naveena; Nutti, M. R.; Martino, Hércia Stampini Duarte; Glahn, Raymond P.; Tako, Elad

doi:10.1016/j.foodres.2019.04.060

Cited by 31 publications

(56 citation statements)

References 57 publications

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“…16S rRNA gene amplification, sequencing, and analysis was performed as previously described [ 11 ]. Briefly, microbial genomic DNA was extracted from cecal samples using the PowerSoil DNA isolation kit, as described by the manufacturer (MoBio Laboratories Ltd., Carlsbad, CA, USA).…”

Section: Methodsmentioning

confidence: 99%

“…Constituents of fiber, such as the prebiotics inulin and raffinose, survive initial digestion in the upper gastrointestinal tract and become subsequently fermented by specific resident commensal bacteria in the colon [ 10 ]. This fermentation leads to the production of short-chain fatty acids (SCFA) [ 11 ]. SCFAs inhibit the growth of harmful pathogens, decrease intestinal pH, upregulate epithelial cell differentiation, thus increasing villus surface area, and upregulate brush-border membrane (BBM) gene expression [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Alterations in the Intestinal Morphology, Gut Microbiota, and Trace Mineral Status Following Intra-Amniotic Administration (Gallus gallus) of Teff (Eragrostis tef) Seed Extracts

et al. 2020

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The consumption of teff (Eragrostis tef), a gluten-free cereal grain, has increased due to its dense nutrient composition including complex carbohydrates, unsaturated fatty acids, trace minerals (especially Fe), and phytochemicals. This study utilized the clinically-validated Gallus gallus intra amniotic feeding model to assess the effects of intra-amniotic administration of teff extracts versus controls using seven groups: (1) non-injected; (2) 18Ω H2O injected; (3) 5% inulin; (4) teff extract 1%; (5) teff extract 2.5%; (6) teff extract 5%; and (7) teff extract 7.5%. The treatment groups were compared to each other and to controls. Our data demonstrated a significant improvement in hepatic iron (Fe) and zinc (Zn) concentration and LA:DGLA ratio without concomitant serum concentration changes, up-regulation of various Fe and Zn brush border membrane proteins, and beneficial morphological changes to duodenal villi and goblet cells. No significant taxonomic alterations were observed using 16S rRNA sequencing of the cecal microbiota. Several important bacterial metabolic pathways were differentially enriched in the teff group, likely due to teff’s high relative fiber concentration, demonstrating an important bacterial-host interaction that contributed to improvements in the physiological status of Fe and Zn. Therefore, teff appeared to represent a promising staple food crop and should be further evaluated.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Alterations in the Intestinal Morphology, Gut Microbiota, and Trace Mineral Status Following Intra-Amniotic Administration (Gallus gallus) of Teff (Eragrostis tef) Seed Extracts

et al. 2020

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“…Furthermore, non-digestible fiber (prebiotics) are dietary substrates that selectively promote proliferation and/or activity of health-promoting bacterial populations in the colon [4]. Prebiotics, such as inulin, raffinose, and stachyose, have a proven ability to promote the abundance of intestinal bacterial populations, which may provide additional health benefits to the host [5][6][7][8][9][10]. Furthermore, various pulse seed soluble (fiber) extracts are responsible for improving gastrointestinal motility, intestinal functionality and morphology, and mineral absorption [9,11].…”

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confidence: 99%

“…Prebiotics, such as inulin, raffinose, and stachyose, have a proven ability to promote the abundance of intestinal bacterial populations, which may provide additional health benefits to the host [5][6][7][8][9][10]. Furthermore, various pulse seed soluble (fiber) extracts are responsible for improving gastrointestinal motility, intestinal functionality and morphology, and mineral absorption [9,11]. Studies have indicated that the consumption of seed-origin soluble extracts can up-regulate the expression of brush border membrane (BBM) proteins that contribute for digestion and absorption of nutrients.…”

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confidence: 99%

“…Studies have indicated that the consumption of seed-origin soluble extracts can up-regulate the expression of brush border membrane (BBM) proteins that contribute for digestion and absorption of nutrients. The soluble extracts can positively affect intestinal health by increasing the mucus production, goblet cells number/diameter, villus surface area, and crypt depth [9,10]. These functional and morphological effects appear to occur due to the increased motility of the digestive tract, leading to hyperplasia and/or hypertrophy of muscle cells.…”

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Dietary Plant-Origin Bio-Active Compounds, Intestinal Functionality, and Microbiome

Tako¹

2020

Nutrients

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In recent years, plant-origin bio-active compounds in foods (staple crops, fruit, vegetables, and others) have been gaining interest, and processes to consider them for public health recommendations are being presented and discussed in the literature. However, at times, it may be challenging to demonstrate causality, and there often is not a single compound–single effect relationship. Furthermore, it was suggested that health benefits may be due to metabolites produced by the host or gut microbiome rather than the food constituent per se. Over the years, compounds that were investigated were shown to increase gut microbial diversity, improve endothelial function, improve cognitive function, reduce bone loss, and many others. More recently, an additional and significant body of evidence further demonstrated the nutritional role and potential effects that plant-origin bio-active compounds might have on intestinal functionality (specifically the duodenal brush border membrane, morphology, and the abundance of health-promoting bacterial populations). Hence, the special issue “Dietary Plant-Origin Bio-Active Compounds, Intestinal Functionality, and Microbiome” comprises 11 peer-reviewed papers on the most recent evidence regarding the potential dietary intake and effects of plant-origin bio-active compounds on intestinal functionality, primarily in the context of brush border functional proteins (enzymes and transporters), mineral (and other nutrients) dietary bioavailability, and the intestinal microbiome. Original contributions and literature reviews further demonstrated the potential dietary relevance that plant bio-active compounds hold in human health and development. This editorial provides a brief and concise overview that addresses and summarizes the content of the Dietary Plant-Origin Bio-Active Compounds, Intestinal Functionality, and Microbiome special issue.

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Common bean (Phaseolus vulgaris L.) α‐amylase inhibitors as safe nutraceutical strategy against diabetes and obesity: An update review

Peddio

Padiglia

Cannea

et al. 2022

Phytotherapy Research

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Overweight and obesity are constantly increasing, not only in Western countries but also in low‐middle‐income ones. The decrease of both the intake of carbohydrates and their assimilation are among the main dietary strategies to counter these conditions. α‐Amylase, a key enzyme involved in the digestion of carbohydrates, is the target enzyme to reduce the absorption rate of carbohydrates. α‐Amylase inhibitors (α‐AIs) can be found in plants. The common bean, Phaseolus vulgaris is of particular interest due to the presence of protein‐based α‐AIs which, through a protein–protein interaction, reduce the activity of this enzyme. Here we describe the nature of the various types of common bean seed extracts, the type of protein inhibitors they contain, reviewing the recent Literature about their molecular structure and mechanism of action. We also explore the existing evidence (clinical trials conducted on both animals and humans) supporting the potential benefits of this protein inhibitors from P. vulgaris, also highlighting the urgent need of further studies to confirm the clinical efficacy of the commercial products. This work could contribute to summarize the knowledge and application of P. vulgaris extract as a nutraceutical strategy for controlling unwanted weight gains, also highlighting the current limitations.

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Soluble extracts from carioca beans (Phaseolus vulgaris L.) affect the gut microbiota and iron related brush border membrane protein expression in vivo (Gallus gallus)

Cited by 31 publications

References 57 publications

Alterations in the Intestinal Morphology, Gut Microbiota, and Trace Mineral Status Following Intra-Amniotic Administration (Gallus gallus) of Teff (Eragrostis tef) Seed Extracts

Alterations in the Intestinal Morphology, Gut Microbiota, and Trace Mineral Status Following Intra-Amniotic Administration (Gallus gallus) of Teff (Eragrostis tef) Seed Extracts

Dietary Plant-Origin Bio-Active Compounds, Intestinal Functionality, and Microbiome

Common bean (Phaseolus vulgaris L.) α‐amylase inhibitors as safe nutraceutical strategy against diabetes and obesity: An update review

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