Soluble epoxide hydrolase inhibitors from <i>Docynia indica</i> (Wall.) Decne.

Duy, Le Xuan; Vinh, Le Ba; Gao, Dan; Hoàng, Vũ Đình; Toàn, Trần Quốc; Yang, Seo Young; Dao, Duy Quang; Kim, Young Ho; Cuong, Nguyen Manh

doi:10.1080/14786419.2020.1774759

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…Previous studies have reported that thunberginol C has cholinesterase inhibition [ 53 ], soluble epoxide hydrolase inhibition [ 54 ], anti-photoaging effects [ 55 ], antioxidant and anti-microbial [ 56 , 57 ], and cyclooxygenase inhibition (anti-inflammatory) [ 55 ] effects. In this study, it was confirmed that thunberginol C had a protective effect on brain cells and suppressed the expression of anxiety symptoms due to stress.…”

Section: Discussionmentioning

confidence: 99%

Hydrangea macrophylla and Thunberginol C Attenuate Stress-Induced Anxiety in Mice

et al. 2022

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Stress is an important neurological input for successful life. However, chronic stress and stress hormones could be a cause of various neurological disorders including anxiety disorders. Therefore, there have been many efforts to find effective materials for curing stress-induced neurological disorders. In this study, we examined the effect of Hydrangea macrophylla (HM) on corticosterone-induced neurotoxicity, stress-induced anxiety in mice and suggested a possible active ingredient of HM. HM protected cortical neurons against neurotoxicity of corticosterone (CORT), a stress hormone. HM also blocked CORT-induced hippocampal synaptic deficit via regulating Akt signaling. Oral administration of HM improved chronic restraint stress-induced anxiety in Elevated Plus maze test along with reduction of plasma corticosterone and TNF-α levels. Moreover, HM reduced stress-induced neuroinflammation and oxidative stress. Thunberginol C, an active ingredient of HM, also prevented CORT-induced neuronal cell death and restraint stress-induced anxiety. Moreover, thunberginol C reduced plasma TNF-α level and neuroinflammation and oxidative stress. Collectively, HM could be a good candidate for preventing stress-induced neurological disorders and thunberginol C may be an active ingredient of HM for this purpose.

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Section: Discussionmentioning

confidence: 99%

Hydrangea macrophylla and Thunberginol C Attenuate Stress-Induced Anxiety in Mice

et al. 2022

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“…This could be particularly important in developing countries. Previously, a number of chemicals from a variety of natural sources have been identified as sEHI, − including urea- and amide-based inhibitors from plants in the order Brassicales. , However, a large number of these compounds have a low potency or their concentrations in the plant are insufficient for clinical application.…”

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confidence: 99%

N-Benzyl-linoleamide, a Constituent of Lepidium meyenii (Maca), Is an Orally Bioavailable Soluble Epoxide Hydrolase Inhibitor That Alleviates Inflammatory Pain

et al. 2020

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Lepidium meyenii (maca), a plant indigenous to the Peruvian Andes, recently has been utilized globally for claimed health or recreational benefits. The search for natural products that inhibit soluble epoxide hydrolase (sEH), with therapeutically relevant potencies and concentrations, led to the present study on bioactive amide secondary metabolites found in L. meyenii, the macamides. Based on known and suspected macamides, 19 possible macamides were synthesized and characterized. The majority of these amides displayed excellent inhibitory potency (IC 50 ≈ 20−300 nM) toward the recombinant mouse, rat, and human sEH. Quantitative analysis of commercial maca products revealed that certain products contain known macamides (1−5, 8−12) at therapeutically relevant total concentrations (≥3.29 mg/g of root), while the inhibitory potency of L. meyenii extracts directly correlates with the sum of concentration/IC 50 ratios of macamides present. Considering both its in vitro efficacy and high abundance in commercial products, N-benzyl-linoleamide (4) was identified as a particularly relevant macamide that can be utilized for in vivo studies. Following oral administration in the rat, compound 4 not only displayed acceptable pharmacokinetic characteristics but effectively reduced lipopolysaccharide-induced inflammatory pain. Inhibition of sEH by macamides provides a plausible biological mechanism of action to account for several beneficial effects previously observed with L. meyenii treatments.

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Isolation of bioactive components with soluble epoxide hydrolase inhibitory activity from Stachys sieboldii MiQ. by ultrasonic-assisted extraction optimized using response surface methodology

Gao

Vinh

Rustam

et al. 2020

Preparative Biochemistry & Biotechnology

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Soluble epoxide hydrolase inhibitors from Docynia indica (Wall.) Decne.

Cited by 3 publications

References 24 publications

Hydrangea macrophylla and Thunberginol C Attenuate Stress-Induced Anxiety in Mice

Hydrangea macrophylla and Thunberginol C Attenuate Stress-Induced Anxiety in Mice

N-Benzyl-linoleamide, a Constituent of Lepidium meyenii (Maca), Is an Orally Bioavailable Soluble Epoxide Hydrolase Inhibitor That Alleviates Inflammatory Pain

Isolation of bioactive components with soluble epoxide hydrolase inhibitory activity from Stachys sieboldii MiQ. by ultrasonic-assisted extraction optimized using response surface methodology

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