“…Soluble epoxide hydrolase (sEH, encoded by the gene EPHX2) is generally considered the relevant epoxide hydrolase for EpETrE conversion to DiHETrEs, while microsomal epoxide hydrolase (mEH, encoded by the gene EPHX1) is considered to be the hydrolase responsible for detoxifying xenobiotics [35]. sEH has been studied in the context of neurodegenerative diseases and recovery after cerebral ischemia, with deletion or inhibition of the enzyme providing neuroprotective and anti-inflammatory effects [3,31,36,37,38,39,40,41,42,43]. Marowsky and colleagues demonstrated that both sEH and mEH are expressed in brain, although with different distributions, and are capable of catalyzing the conversion of EpETrEs to DiHETrEs [29].…”