Soluble Epoxide Hydrolase, a Target with Multiple Opportunities for Cardiovascular Drug Discovery

Marino, Joseph P.

doi:10.2174/156802609788340805

Cited by 43 publications

(57 citation statements)

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“…Cytochrome P450 enzymes could participate in the syntheses of prostaglandins known to be secreted in tick saliva [28-32]. Soluble epoxide hydrolases, if secreted, may affect host prostanoids [33, 34]. Some CDS of sphingomyelinases and deoxyribonucleases also show presence of signal peptides; such secreted enzymes could affect host immunity signaling [35] and affect host neutrophil extracellular traps (NETs) [36], respectively.…”

Section: Resultsmentioning

confidence: 99%

Sexual differences in the sialomes of the zebra tick, Rhipicephalus pulchellus

Tan

Francischetti

Slovák

et al. 2015

Journal of Proteomics

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Ticks rely exclusively on vertebrate blood for their survival. During feeding ticks inject into their hosts a sophisticated salivary potion that overcomes host hemostasis and adverse inflammatory responses. These mediators may also enhance pathogen transmission. Knowledge of the tick salivary protein repertoire may lead to vaccine targets to disrupt feeding and/or parasite transmission as well as to the discovery of novel pharmacological agents. Male saliva may also assist reproduction because males use their mouthparts to lubricate and introduce their spermatophores into the females’ genital pore. The analyses of the sialomes of male and female ticks independently allow us to understand the strategy used by each gender to feed successfully.We sequenced cDNA libraries from pools of salivary glands from adult male and female R. pulchellus feeding at different time points, using the Illumina HiSeq protocol. De novo assembly of a total of 241,229,128 paired-end reads lead to extraction of 50,460 coding sequences (CDS), 11,277 of which had more than 75% coverage to known transcripts, or represented novel sequences, and were submitted to GenBank. Additionally, we generated the proteome, from the salivary gland extracts of male and female R. pulchellus, yielding a total of 454 and 2,063 proteins respectively which were identified by one or more peptides with at least 95% confidence. The data set is presented as an annotated hyperlinked Excel spreadsheet, describing 121 putative secreted protein families. Female and male specific transcripts were identified.

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Section: Resultsmentioning

confidence: 99%

Sexual differences in the sialomes of the zebra tick, Rhipicephalus pulchellus

Tan

Francischetti

Slovák

et al. 2015

Journal of Proteomics

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“…51,53 This development of sEH inhibitors has been extensively chronicled in a number of excellent review articles. 51,54,55 …”

Section: Therapeutic Approaches – Hypertension and Kidney Diseasesmentioning

confidence: 99%

Epoxyeicosatrienoic Acids, Hypertension, and Kidney Injury

Imig

2015

Hypertension

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“…Because EET turnover by EH is evolving as a promising target for therapeutic intervention ( 11 ) and, in particular, with the expected role of D173 as the catalytic nucleophile because self-activation by autocatalytic hydrolysis from the mutant asparagine to the wild-type aspartic acid side chain has been reported for the equivalent mutants of other EHs ( 34,35 ).…”

Section: Eh3 Is Inhibited By Urea Derivatives Regarded As Specifi C Fmentioning

confidence: 99%