Soluble Endothelial Selectin in Acute Lung Injury Complicated by Severe Pneumonia

Abstract

Background: Pneumonia is still one of the most frequent causes of death in the elderly. Complication of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) by pneumonia makes patients very ill due to severe respiratory failure. Biomarkers that can discriminate the presence of complicating ALI/ARDS are required for early detection. The aim of this research was to investigate whether soluble endothelial selectin (sES) could be a biomarker for ALI.Methods: Serum sES levels were measured in 27 pneumonia patients, who were enrolled between April 2006 and September 2007. Among these patients, six had ALI or a condition that was clinically comparable to ALI (cALI). All patients who were enrolled were successfully treated and survived.Results: Circulating sES levels were elevated in pneumonia patients with ALI/cALI, and sES levels decreased following treatment of their pneumonia. Univariate and multivariate logistic regression analyses showed that sES was the only significant factor for identifying complicating ALI/cALI, independently of C-reactive protein (CRP) and lactate dehydrogenase (LDH). By receiver operating characteristic (ROC) curve analysis, the cut-off value for sES was 40.1 ng/mL, with a sensitivity of 0.8 and a specificity of 0.8.Conclusion: sES may be a useful biomarker for discriminating complicating ALI/cALI in patients with severe pneumonia.

E-selectin as a prognostic factor of patients hospitalized due to acute inflammatory respiratory diseases: a single institutional study

“…The measurement of E-selectin serum levels in patients with severe pneumonia may be useful for discriminating between complicating ALI or cALI (Osaka et al, 2011[16]). This study showed that E-selectin is a more effective biomarker for predicting the onset of ALI than white blood cell count, CRP, and LDH, which have been well-known biomarkers for a long time.…”

“…We demonstrated previously that E-selectin predicts the occurrence of acute lung injury (ALI) in pneumonic patients. E-selectin serum levels were elevated in pneumonic patients with ALI or clinically comparable ALI (cALI) (Osaka et al, 2011[16]). We investigated whether evaluating the circulating serum E-selectin levels in patients with severe pneumonia can be useful for the prediction of complicating ALI or cALI (Osaka et al, 2011[16]).…”

“…E-selectin serum levels were elevated in pneumonic patients with ALI or clinically comparable ALI (cALI) (Osaka et al, 2011[16]). We investigated whether evaluating the circulating serum E-selectin levels in patients with severe pneumonia can be useful for the prediction of complicating ALI or cALI (Osaka et al, 2011[16]). Based on this foundation, we hypothesized that E-selectin plays an important role in the severity of acute inflammatory respiratory diseases such as infectious pneumonia and interstitial pneumonia.…”

Assessment of acute lung injury/acute respiratory distress syndrome using B-type brain natriuretic peptide

“…Studies show that the CRP level significantly increases in patients with ALI/ARDS. 23 In light of its mechanism of action, it is likely that the CRP level will increase with the severity of disease. In the present study, CRP levels in all three ALI/ ARDS groups were significantly higher than in the non-ALI/ARDS group.…”

Polymorphisms in SELE Gene and Risk of Coal Workers' Pneumoconiosis in Chinese: A Case-Control Study

“…Its corresponding gene, SELE (CD62E; ELAM1), is located on human chromosome 1q22-q25 [10]. Recent studies have confirmed that E-selectin is involved in pulmonary diseases [11], [12]. Here we evaluated the frequency distributions of three SELE single nucleotide polymorphisms (SNPs) to explore the association between these polymorphisms and CWP.…”