Soluble Endoglin and Other Circulating Antiangiogenic Factors in Preeclampsia

Levine, Richard J.; Lam, Chun; Qian, Cong; Yu, Kai F.; Maynard, Sharon E.; Sachs, Benjamin P.; Sibai, Baha M.; Epstein, Franklin H.; Romero, Roberto; Thadhani, Ravi; Karumanchi, S. Ananth

doi:10.1056/nejmoa055352

Cited by 1,673 publications

(1,160 citation statements)

References 35 publications

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“…Serum levels of sEng in normal pregnancy are quite stable and slightly increase by 33-42 wk of gestation [87] . Placental endoglin is up-regulated in preeclampsia and released in the circulation.…”

Section: Soluble Endoglinmentioning

confidence: 97%

“…Rising levels of circulating soluble endoglin (sEng) herald the onset of preeclampsia. Women with higher sEng levels at 21 through 32 wk of gestation had an increased risk of preterm preeclampsia and an increased risk for a small-for-gestational-age infant [87] . Cellfree fetal DNA Cellfree fetal DNA (cffDNA) is increased at 11-13 wk of gestation in pregnancies that experience preeclampsia [88] .…”

Section: Soluble Endoglinmentioning

confidence: 97%

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Preeclampsia from a renal point of view: Insides into disease models, biomarkers and therapy

Müller-Deile

Schiffer

2014

WJN

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Proteinuria is a frequently detected symptom, found in 20% of pregnancies. A common reason for proteinuria in pregnancy is preeclampsia. To diagnose preeclampsia clinically and to get new insights into the pathophysiology of the disease it is at first essential to be familiar with conditions in normal pregnancy. Animal models and biomarkers can help to learn more about disease conditions and to find new treatment strategies. In this article we review the changes in kidney function during normal pregnancy and the differential diagnosis of proteinuria in pregnancy. We summarize different pathophysiological theories of preeclampsia with a special focus on the renal facets of the disease. We describe the current animal models and give a broad overview of different biomarkers that were reported to predict preeclampsia or have a prognostic value in preeclampsia cases. We end with a summary of treatment options for preeclampsia related symptoms including the use of plasmapheresis as a rescue therapy for so far refractory preeclampsia. Most of these novel biomarkers for preeclampsia are not yet implemented in clinical use. Therefore, we recommend using proteinuria (measured by UPC ratio) as a screening parameter for preeclampsia. Delivery is the only curative treatment for preeclampsia. In early preeclampsia the primary therapy goal is to prolong pregnancy until a state were the child has an acceptable chance of survival after delivery.© 2014 Baishideng Publishing Group Inc. All rights reserved.Key words: Preeclampsia; Pregnancy; Proteinuria; Biomarkers; Treatment Core tip: This review summarises different pathophysiological theories of preeclampsia with a special focus on the renal facets of the disease. In this context current animal models are presented. The reader gets a broad overview about different biomarkers for preeclampsia. Furthermore, the article discusses treatment options for preeclampsia related symptoms including the use of plasmapheresis as a rescue therapy for so far refractory preeclampsia.Müller-Deile J, Schiffer M. Preeclampsia from a renal point of view: Insides into disease models, biomarkers and therapy. World

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Section: Soluble Endoglinmentioning

confidence: 97%

Section: Soluble Endoglinmentioning

confidence: 97%

Preeclampsia from a renal point of view: Insides into disease models, biomarkers and therapy

Müller-Deile

Schiffer

2014

WJN

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“…[14,15] Subsequent studies have demonstrated the role of these anti-angiogenic factors in the pathogenesis of pre-eclampsia in humans. [16][17][18] Clinically, vascular endothelial dysfunction and microangiopathy are present in the mother, but not in the fetus. The predominant target organ may be the brain (seizures or eclampsia), the liver (HELLP syndrome), or the kidney (glomerular endotheliosis and proteinuria).…”

Section: Estimating Proteinuria In Pregnancymentioning

confidence: 99%

Pregnancy and the kidneys

Wearne

2014

S Afr Med J

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“…Soluble endoglin (s-Eng) has been found elevated approximately 2-3 months before clinical presentation of the PE [60]. When, s-Eng used as first trimester screening marker, it shows conflicting results [42].…”

Section: Soluble Endoglinmentioning

confidence: 99%

Prediction of the preeclampsia: a view of biochemical markers

Bostancı

Bayram

Cevrioğlu

et al. 2013

RHC

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Preeclampsia is a diverse, multiorgan group of related disease processes that occurs in up to 5%-8% of pregnancies after 20 weeks' gestation and it is one of the leading causes of maternal and fetal morbidity and mortality. Many molecular mechanisms are contributed to the pathogenesis of preeclampsia. Although it is unknown whether the mechanisms act independently or have synergistic effects. This review describes review of primary papers investigating blood based biomarker such as PAP-A, Inhibin A, sFlt1, and PP13 in general and first trimester biochemical markers and combinations of them specifically for preeclampsia.

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Soluble Endoglin and Other Circulating Antiangiogenic Factors in Preeclampsia

Abstract: Rising circulating levels of soluble endoglin and ratios of sFlt1:PlGF herald the onset of preeclampsia.

Cited by 1,673 publications

References 35 publications

Preeclampsia from a renal point of view: Insides into disease models, biomarkers and therapy

Preeclampsia from a renal point of view: Insides into disease models, biomarkers and therapy

Pregnancy and the kidneys

Prediction of the preeclampsia: a view of biochemical markers

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