Soluble CD44 concentration in the serum and peritoneal fluid samples of patients with different stages of endometriosis

Mashayekhi, Farhad; Aryaee, Hadis; Mirzajani, Ebrahim; Yasin, Ashraf Ale; Fathi, Abdolsatar

doi:10.1007/s00404-015-3654-9

Cited by 11 publications

(8 citation statements)

References 20 publications

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“…Similarly, HCAM (also referred as CD44) is upregulated in endometriosis tissue, and inhibition of HCAM glycosylation decreases endometrial cell attachment to peritoneal mesothelial cells . Furthermore, higher levels of the soluble form of HCAM in sera and pelvic fluids were found in patients with endometriosis . These observations suggest that both ICAM‐1 and HCAM may play critical roles in the pathogenesis of endometriosis.…”

Section: Discussionmentioning

confidence: 94%

Decoy receptor 3 promotes cell adhesion and enhances endometriosis development

Tsai

Huang

Wang

et al. 2017

The Journal of Pathology

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Endometriosis is a multifactorial inflammatory disease with persistent activation of the nuclear factor-κB (NF-κB) signalling pathway. Aberrant adhesion of endometrium is the essential step in the progression of endometriosis, but the molecular mechanism of ectopic growth of endometrium is still unclear. Decoy receptor 3 (DcR3)/TNFRSF6B, a pleiotropic immunomodulator regulated by oestrogen, is able to activate focal adhesion kinase to promote cell adhesion. We found that DcR3 is upregulated in human ectopic endometrial cells via activation of the Akt-NF-κB signalling pathway, and its expression level correlates positively with that of the adhesion molecules intercellular adhesion molecule 1 (ICAM-1) and homing cell adhesion molecule (HCAM; CD44). In a multivariate regression model, DcR3 expression level was the most significant parameter associated with endometriosis severity. Knockdown of DcR3 not only downregulated the expression of ICAM-1 and HCAM, but also reduced cell adhesion and migration. In vivo investigation further showed that DcR3 promoted the growth and spread of endometrium, whereas knockdown of DcR3 by lentivirus-delivered short hairpin RNA inhibited ectopic adhesion of endometrium and abrogated endometriosis progression. These observations are in support of DcR3 playing a critical role in the pathogenesis of endometriosis, and the inhibition of DcR3 expression being a promising approach for the treatment of endometriosis. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 94%

Decoy receptor 3 promotes cell adhesion and enhances endometriosis development

Tsai

Huang

Wang

et al. 2017

The Journal of Pathology

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“…In addition, although the mechanism remains unclear, CD44 and HA are both correlated with drug resistance [10]. Overall, CD44 is a potential prognostic marker for various diseases [48][49][50].…”

Section: Discussionmentioning

confidence: 98%

The prognostic value and clinicopathological significance of CD44 expression in ovarian cancer: a meta-analysis

Zhao

Zhang

et al. 2016

Arch Gynecol Obstet

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High CD44s expression possibly indicates poor prognosis in OC patients given that high CD44s expression initiates chemotherapy resistance, although this expression pattern is not an independent predictive factor for OS. Meanwhile, high CD44s expression may be related to poor DFS of OC, but this relationship must be further confirmed. In addition, the result in which CD44v6 is not associated with OS of OC patients should be interpreted with caution.

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“…90 Recently, it was observed that sCD44 increases in hepatic steatosis 91 and chronic and aggressive periodontal disease, 92 and its levels correlate with the evolution of endometriosis. 93 One study analyzed sEpCAM in endometriosis, and did not find any correlation. 94 Thus, the soluble forms of these adhesion molecules suffer significant changes in other pathological conditions besides cancer.…”

Section: Hematological Malignanciesmentioning

confidence: 98%

Cell-adhesion molecules and their soluble forms: Promising predictors of “tumor progression” and relapse in leukemia

et al. 2018

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Some surface markers are used to discriminate certain leukemic subpopulations that retain a greater oncogenic potential than others, and, for this reason, they were termed as leukemic stem cells, similar to the concept of cancer stem cells in carcinoma. Among these surface markers are proteins involved in cell-cell adhesion or cell-matrix adhesion, and they may play a role in the relapse of leukemia, similar to metastasis in carcinomas. The most important are epithelial cadherin, neural cadherin, epithelial cell-adhesion molecule, and CD44, which can be cleaved and released, and their soluble forms were found increased in serum levels of cancer patients, being implicated, in some cases, with progression, metastases, and relapse. In this review, we highlighted the role of these four adhesion molecules in carcinomas and hematological malignancies, mainly leukemia, and discuss if the serum levels of soluble forms can be correlated with the surface protein status on the leukemic cells. Accession of the soluble forms looks attractive, but their use as markers in cancer must be studied in association with other parameters, as there are significant changes in levels in other pathological conditions besides cancer. Studies correlating the levels of the forms with the status of the membrane-bound proteins in leukemic (stem) cells and correlating those parameters with relapse in leukemia may afford important knowledge and applicability of those serum markers in clinical practice. For instance, the expression of the membrane-bound forms of these adhesion proteins may have promising clinical use in leukemia and other hematological malignancies.

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Soluble CD44 concentration in the serum and peritoneal fluid samples of patients with different stages of endometriosis

Abstract: The results of this study show that a high expression of sCD44 is correlated with advanced stages of endometriosis. It is also concluded that the detection of serum and/or peritoneal fluid sCD44 may be useful in classifying endometriosis.

Cited by 11 publications

References 20 publications

Decoy receptor 3 promotes cell adhesion and enhances endometriosis development

Decoy receptor 3 promotes cell adhesion and enhances endometriosis development

The prognostic value and clinicopathological significance of CD44 expression in ovarian cancer: a meta-analysis

Cell-adhesion molecules and their soluble forms: Promising predictors of “tumor progression” and relapse in leukemia

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