Soluble CD30 is more relevant to disease activity of atopic dermatitis than soluble CD26

Abstract

SUMMARYIt is suggested that CD30 and CD26 are surface molecules expressed on activated Th2 and Th1 cells, respectively. We examined plasma levels of soluble CD26 (sCD26) and sCD30 in patients with atopic dermatitis (AD) when their eruptions were aggravated and in non-atopic healthy controls, and then analysed the possible correlation between these values and the levels of several clinical markers. The plasma levels of both sCD30 and sCD26 were significantly higher in AD patients than in controls, both in exacerbation status and after conventional treatment. Multiple regression analyses showed that plasma sCD30 was a much better predictor of the levels of serum IgE, serum LDH and plasma sCD25, and the area and the score of AD eruption than sCD26, although elevated levels of both sCD30 and sCD26 are associated with these clinical predictors of AD. Importantly, sCD30 plasma levels decreased significantly in AD patients after conventional treatment, while no significant transition was noted in the concentration of sCD26. Moreover, a significant reduction of sCD30 levels was observed in the group of patients whose eruption score was reduced . 50%, whereas it was not in those , 50%. These findings provide evidence that the successful treatment of AD is associated with down-activation of Th2.

Improvement in lung function is associated with a decrease in serum soluble CD30 in atopic infants

“…9 Conversely, corticosteroids suppress inflammation by inhibiting the action of nuclear factor-kB. 10 Consistent with that, and in line with previous intervention studies, 1,5 the decrease in serum sCD30 seen in our study was linked to the concurrent improvement of lung function, especially in children with atopy who received inhaled budesonide.…”

“…1,2 In contrast, sCD26 has been found to be inversely associated with disease severity in patients with chronic eosinophilic pneumonia. 3 Increased levels of sCD30 in serum samples have been found in patients with atopic dermatitis, 4 and an association between elevated sCD30 and the severity of eczema has been observed.…”

Soluble CD26 and CD30 levels in patients with anthroponotic cutaneous leishmaniasis

“…19,29 A correlation between sCD30 levels and disease activity has also been reported in patients with atopic dermatitis and in asthma. 28,30 An inverse correlation of sCD26 with disease activity has been reported in patients with systemic lupus erythematosus and anti-neutrophil cytoplasm antibody-associated vasculitides. 21,31 We have shown elevated levels of sCD26 and sCD30 in individuals infected with Leishmania infantum.…”

“…High levels of both sCD26 and sCD30 have been reported in atopic dermatitis which is a Th2-related chronic inflammatory skin disease. 28 It seems that in skin inflammatory diseases the sCD26 level in plasma is less representative marker for Th1-dominated response or disease activity.…”

Serum Levels of Soluble CD26 and CD30 in Patients on Hemodialysis

“…Latest reports indeed investigated the Th1/Th2 balance during several diseases by analysis of the serum sCD26 and sCD30 levels [31, 32, 33]. Recently, it was concluded that CD26 upregulation may be suggestive of Th1-like immune reactions and that the release of sCD26 correlates with cell surface CD26 expression [10, 11, 34].…”