2018
DOI: 10.1016/j.jri.2018.05.006
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Soluble CD200 in secretory phase endometriosis endometrial venules may explain endometriosis pathophysiology and provide a novel treatment target

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Cited by 12 publications
(27 citation statements)
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“…The authors concluded that CD200 was an important immunosuppressive marker in EMS and it might promote the development of the disease via the inhibition of phagocytosis. Clark et al [ 53 ] analyzed CD200 and CD200R1 expression in eutopic and ectopic deposits of EMS and in deposits of adenomyosis, with immunohistochemistry staining. They observed a different staining intensity in ectopic peritoneal implants and cystic forms in the tissue of EMS patients.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The authors concluded that CD200 was an important immunosuppressive marker in EMS and it might promote the development of the disease via the inhibition of phagocytosis. Clark et al [ 53 ] analyzed CD200 and CD200R1 expression in eutopic and ectopic deposits of EMS and in deposits of adenomyosis, with immunohistochemistry staining. They observed a different staining intensity in ectopic peritoneal implants and cystic forms in the tissue of EMS patients.…”
Section: Discussionmentioning
confidence: 99%
“…Our results show that the expression of CD200 and CD200R on lymphocyte subsets, particularly on CD19+ B lymphocytes (measured by flow cytometry), may be a good marker enabling the differentiation between EMS patients and healthy controls. While several studies have shown expression of CD200/CD200R in ectopic endometrial tissue, a means to distinguish between patients in a less invasive and time-consuming manner is still needed [ 53 , 54 ].…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, signals from the endometrial tissues also affected the immune function; for example, CD200 from endometrial venules could promote Tregs and indoleamine 2,3-dioxygenase-producing macrophages, and inhibit cytolytic NK cells and neutrophils in the pathology of endometriosis progression. 23 Thrombin and thromboxane A2 secreted from stromal cells 24 could induce platelet activation, and the activated platelets then mediated NK cytotoxicity through NKG2D and TGF-β signals during endometriosis progression. 25 , 26 It is therefore possible that activated NK cells may cooperate with other immune cells in their interactions with stromal cells and platelets in endometriosis progression.…”
Section: Discussionmentioning
confidence: 99%
“…Considering the retrograde menstruation theory, this may explain the development of ectopic lesions. The authors of the above report propose that the quantification of soluble CD200 in menstrual blood is a method to verify a predisposition to endometriosis development [188].…”
Section: The Cd200 Molecule and Its Receptor Cd200rmentioning
confidence: 99%