Soluble CD200 in secretory phase endometriosis endometrial venules may explain endometriosis pathophysiology and provide a novel treatment target

Clark, David A.; Dmetrichuk, Jennifer M.; Dhesy‐Thind, Sukhbinder; Crowther, Mark; Arredondo, Jorge

doi:10.1016/j.jri.2018.05.006

Cited by 12 publications

(28 citation statements)

References 44 publications

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“…The authors concluded that CD200 was an important immunosuppressive marker in EMS and it might promote the development of the disease via the inhibition of phagocytosis. Clark et al [ 53 ] analyzed CD200 and CD200R1 expression in eutopic and ectopic deposits of EMS and in deposits of adenomyosis, with immunohistochemistry staining. They observed a different staining intensity in ectopic peritoneal implants and cystic forms in the tissue of EMS patients.…”

Section: Discussionmentioning

confidence: 99%

“…Our results show that the expression of CD200 and CD200R on lymphocyte subsets, particularly on CD19+ B lymphocytes (measured by flow cytometry), may be a good marker enabling the differentiation between EMS patients and healthy controls. While several studies have shown expression of CD200/CD200R in ectopic endometrial tissue, a means to distinguish between patients in a less invasive and time-consuming manner is still needed [ 53 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

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CD200 and CD200R Expression on Peripheral Blood Lymphocytes and Serum CD200 Concentration as a New Marker of Endometriosis

Abramiuk

Grywalska

Korona-Głowniak

et al. 2020

JCM

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The causes of endometriosis (EMS) remain unknown; however, a number of immunological abnormalities contribute to the pathogenesis of the disease. The cluster of differentiation-200 (CD200) and its receptor (CD200R) maintain peripheral self-tolerance by negatively regulating immune responses. In this comparative cross-sectional study, we investigated the expression of CD200 and CD200R on T and B lymphocytes and the serum level of soluble CD200 (sCD200) using flow cytometry and ELISA, respectively. Peripheral blood samples were collected from 54 female patients and 20 healthy, age-matched controls. Results were tested for correlation with disease severity and selected clinical parameters. We demonstrated that the differences in sCD200 levels (p = 0.001), the frequencies of CD200-positive T and B lymphocytes (p < 0.001 and p = 0.004, respectively), and the frequencies of CD200R-positive T and B lymphocytes (p < 0.001 for all comparisons) in the study group correlated positively with disease severity. Receiver operating characteristic (ROC) analysis indicated that aberrant expression of CD200/CD200R might serve as a marker to distinguish between EMS cases. Finally, negative co-stimulatory factors may contribute to the induction and persistence of inflammation associated with EMS. It seems that it is essential to determine whether alteration in the CD200/CD200R pathway can be therapeutically targeted in EMS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

CD200 and CD200R Expression on Peripheral Blood Lymphocytes and Serum CD200 Concentration as a New Marker of Endometriosis

Abramiuk

Grywalska

Korona-Głowniak

et al. 2020

JCM

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“…Furthermore, signals from the endometrial tissues also affected the immune function; for example, CD200 from endometrial venules could promote Tregs and indoleamine 2,3-dioxygenase-producing macrophages, and inhibit cytolytic NK cells and neutrophils in the pathology of endometriosis progression. 23 Thrombin and thromboxane A2 secreted from stromal cells 24 could induce platelet activation, and the activated platelets then mediated NK cytotoxicity through NKG2D and TGF-β signals during endometriosis progression. 25 , 26 It is therefore possible that activated NK cells may cooperate with other immune cells in their interactions with stromal cells and platelets in endometriosis progression.…”

Section: Discussionmentioning

confidence: 99%

Involvement of natural killer cells in the pathogenesis of endometriosis in patients with pelvic pain

et al. 2020

J Int Med Res

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Objectives To detect the involvement of immune cells in the pathogenesis of endometriosis in patients with stable status or pelvic pain. Methods Blood was collected from patients with endometriosis with and without pelvic pain. Natural killer (NK) and Th17 cells were analyzed by flow cytometry, and secretion of inflammatory cytokines (tumor necrosis factor-α, interleukin (IL)-1β, IL-6, IL-7) was verified by enzyme-linked immunosorbent assay. We isolated immune cells from blood by density-gradient centrifugation to investigate the expression of functional molecules including sterile alpha motif domain-containing protein 9 (SAMD9), Ral guanine nucleotide dissociation stimulator-like 2 (RGL2), early growth response protein 1, and Akirin2. We also searched the BIOGPS database for protein expression profiles. Results SAMD9 and RGL2 expression levels were significantly upregulated in patients with pelvic pain. Furthermore, lysophosphatidic acid receptor 1 expression was higher in endometrial tissues from patients with pelvic pain, and was mainly localized in stromal and glandular epithelial cells in ectopic lesions. Conclusion NK cells play an important role in the pathogenesis of endometriosis in patients with pelvic pain. Suppressing the cytotoxic activity of NK cells may thus help to reduce the progression of pelvic pain in patients with endometriosis.

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“…Considering the retrograde menstruation theory, this may explain the development of ectopic lesions. The authors of the above report propose that the quantification of soluble CD200 in menstrual blood is a method to verify a predisposition to endometriosis development [188].…”

Section: The Cd200 Molecule and Its Receptor Cd200rmentioning

confidence: 99%

The Role of the Immune System in the Development of Endometriosis

Abramiuk

Grywalska

Małkowska

et al. 2022

Cells

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Endometriosis is a chronic disease that affects about 10% of women of reproductive age. It can contribute to pelvic pain, infertility or other conditions such as asthma, cardiovascular disease, breast or ovarian cancer. Research has shown that one of the conditions for the development of endometrial lesions is the dysfunction of the immune system. It appears that immune cells, such as neutrophils, macrophages, NK cells and dendritic cells, may play a specific role in the angiogenesis, growth and invasion of endometriosis cells. Immune cells secrete cytokines and defensins that also affect the endometriosis environment. This review discusses the various components of the immune system that are involved in the formation of endometrial lesions in women.

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Soluble CD200 in secretory phase endometriosis endometrial venules may explain endometriosis pathophysiology and provide a novel treatment target

Cited by 12 publications

References 44 publications

CD200 and CD200R Expression on Peripheral Blood Lymphocytes and Serum CD200 Concentration as a New Marker of Endometriosis

CD200 and CD200R Expression on Peripheral Blood Lymphocytes and Serum CD200 Concentration as a New Marker of Endometriosis

Involvement of natural killer cells in the pathogenesis of endometriosis in patients with pelvic pain

The Role of the Immune System in the Development of Endometriosis

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