Soluble biomarkers of HIV transmission, disease progression and comorbidities

Leeansyah, Edwin; Malone, David F. G.; Anthony, Donald D.; Sandberg, Johan K.

doi:10.1097/coh.0b013e32835c7134

Cited by 69 publications

(72 citation statements)

References 58 publications

(39 reference statements)

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“…As markers of immune activation, the plasma sCD14 and sCD163 levels are elevated during HIV-1 infection and are useful in predicting the activation status of the monocyte response, HIV activity and pathogenesis. [1][2][3][4][5][6] Toll-like receptors (TLRs) are abundantly expressed on monocytes and are involved in innate monocyte responses. Many studies suggested that TLR responses contribute to the disease progression and clinical outcomes of viral infections, including HIV infections.…”

Section: Introductionmentioning

confidence: 99%

Higher levels of circulating monocyte–platelet aggregates are correlated with viremia and increased sCD163 levels in HIV-1 infection

Liang

Duan

et al. 2014

Cell Mol Immunol

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Increased levels of monocyte-platelet aggregates (MPAs) are reported to be highly correlated with cardiovascular events. In this study, the MPA levels in different monocyte subsets and the associations between MPA levels, HIV-1 viremia and monocyte activation were evaluated during HIV-1 infection. The results showed that the percentages of MPAs in all three monocyte subsets were higher in HIV-1-infected subjects than in healthy controls, and were associated with the plasma viral load in the non-classical and intermediate monocyte subsets. The plasma levels of sCD14 and sCD163 were upregulated in HIV-1 infection and were positively associated with viral loads and negatively associated with CD4 counts. P-selectin glycoprotein ligand-1 (PSGL-1) was shown to be expressed at significantly lower levels on all three monocyte subsets and was negatively correlated with the sCD163 level. The MPA level was correlated with the levels of plasma sCD163 but negatively correlated with CD163 and PSGL-1 on all three monocyte subsets. An elevated immune activation status was correlated with increased MPA formation, underlying the potential interaction between monocyte activation and MPA formation. This interaction may be related to a higher thromboembolic risk in patients infected with HIV-1.

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Section: Introductionmentioning

confidence: 99%

Higher levels of circulating monocyte–platelet aggregates are correlated with viremia and increased sCD163 levels in HIV-1 infection

Liang

Duan

et al. 2014

Cell Mol Immunol

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show abstract

“…Duyarlılığı azalan virüslerin çoğalması, ilaç konsantrasyonu artırılarak baskılanabilir. IC 50 değerleri oranlanarak test edilen virüsün IC 50 'sinin, referans virüs IC 50 'sinin kaç katı olduğu belirlenir ve bu değer sınır değer ile karşılaştırılır. Sınır değer virüsün baskılanması ya da duyarlı olarak sınıflandırılabilmesi için virü-sün IC 50 değerinin kaç kat arttırılması gerektiği-ni gösterir (34,35) .…”

Section: İlaç Direnci Testleriunclassified

“…Bu süreçler edinilmiş ve adaptif immün aktivasyon ile ilgili çözünür belirteçlerin ortaya çıkmasına, hücre ölümüne ve dokunun yapısının bozulmasına neden olurlar (50) .…”

Section: Yeni Biobelirteçlerunclassified

“…Dolayısıyla hiperakut enfeksiyon için olası bir biyobelirteç görevi görebilir. A-SAA bifazik bir yanıt göstermiş; ilki viral eklips fazında ve ikincisi de akut HIV-1 enfeksiyonu ile ilişkilendiri-len sitokin fırtınası ile örtüşen viral ekspansiyon fazında gözlenmiştir (50) .…”

Section: Yeni Biobelirteçlerunclassified

“…(54) , başlangıçtaki enfeksiyondan altı hafta sonra tümör nekroz faktörü (TNF), IP-10 ve interlökin (IL)-10'un yükseldiğini doğrulamışlar ve ayrıca enfeksiyondan 12 ay sonraki viral yük karar düzeyini tahmin etmek için kullanılabile-cek, akut enfeksiyon sırasında ölçülen beş sitokinden oluşan bir model öne sürmüşlerdir. IL-12p40/70, IFNg, IL-7 ve IL-15'in plazma konsantrasyonları birlikte kullanıldığında, viral karar düzey varyasyonunun %66'sı tahmin edilebilmiştir (50) .…”

Section: Yeni Biobelirteçlerunclassified

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Current Diagnostic Algorithm of HIV and Emerging Prevention Methods

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Revolutionizing Infection Risk Scoring: An Ensemble “From Weak to Strong” Deduction Strategy and Enhanced Point‐of‐Care Testing Tools

Chen,

Ye,

Chen

et al. 2023

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The COVID‐19 pandemic exacerbates challenges faced by human immunodeficiency virus patients, who are at heightened risk for infection due to compromised immune systems. This study aims to develop a reliable, home‐based point‐of‐care testing (POCT) tool for early screening of acquired immunodeficiency syndrome (AIDS) coinfected with Talaromyces marneffei infection. Employing a “From weak to strong” deduction strategy for feature selection, data from 464 AIDS patients across four cohorts between February 5th, 2014, and January 8th, 2022, are analyzed. The top three features consistently observed are D‐dimer, cluster of differentiation 4+, and aspartate transaminase. Based on these features, the simplest risk‐scoring model is constructed, with the area under the receiver operating characteristic curve values of 0.91, 0.80, and 0.69 in the hold‐out cohort, external cohort 1, and external cohort 2, respectively. This “From weak to strong” deduction strategy identifies advantageous clinical features, enabling the development of simplified clinical risk scores with multiple biomarkers. To facilitate practical implementation, enhanced POCT tools are introduced, specifically a strip with segmented testing capabilities that demonstrates sensitivity and strong correlation with clinical scoring models. Furthermore, an open‐access website and a free Android mobile app are created to support community utilization. The findings underscore the effectiveness of the innovative deduction strategy and enhanced test strips, which enable bedside measurements without laboratory dependency.

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Soluble biomarkers of HIV transmission, disease progression and comorbidities

Abstract: Soluble biomarkers help us understand HIV-1 immunopathogenesis. Integration of many biomarkers derived from a single plasma sample might become a powerful tool to optimize and individualize treatment and care.

Cited by 69 publications

References 58 publications

Higher levels of circulating monocyte–platelet aggregates are correlated with viremia and increased sCD163 levels in HIV-1 infection

Higher levels of circulating monocyte–platelet aggregates are correlated with viremia and increased sCD163 levels in HIV-1 infection

Current Diagnostic Algorithm of HIV and Emerging Prevention Methods

Revolutionizing Infection Risk Scoring: An Ensemble “From Weak to Strong” Deduction Strategy and Enhanced Point‐of‐Care Testing Tools

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