Soluble and cell-associated triggering receptor expressed on myeloid cells-1 and -2 in patients with pulmonary tuberculosis

Hoogendijk, Arie J.; Blok, Dana C.; Laorden, M. Isabel Garcia; Kager, Liesbeth M.; Lede, Ivar O.; Rahman, Waliur; Afroz, Rumana; Bresser, Paul; Zee, J.S. van der; Ghose, Aniruddha; Visser, Caroline E.; Jong, Menno D. de; Zahed, Abu Shahed Md; Husain, Anwar; Alam, Khan Mashrequl; Barua, Pravat Chandra; Hassan, Mahtabuddin; Hossain, Ahmed; Tayab, Abu; Lutter, René; Day, Nick; Dondorp, Arjen M.; Veer, Cornelis van’t; Vos, Alex F. de; Poll, Tom van der

doi:10.1016/j.jinf.2015.09.002

Cited by 8 publications

(9 citation statements)

References 10 publications

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“…TREM-2 is initially identified as an innate receptor on myeloid cells. A previous study reported that TREM-2 is expressed in CD4 + and CD8 + T cells from patients with TB (26). In the present study, we found that the percentage of peripheral TREM-2 + CD4 + T cells was upregulated in patients with active TB versus HCs.…”

Section: Discussionsupporting

confidence: 68%

“…TLT2 is also constitutively expressed on CD8 + T cells and enhances IL-2 and IFN-γ production (25). Furthermore, TREM-2 expression in CD4 + and CD8 + T cells has been reported in patients with TB (26), however, the function of TREM-2 in TB remains unknown. Together, these observations indicate the potential roles of TREM family members in lymphocytes.…”

Section: Introductionmentioning

confidence: 99%

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TREM-2 promotes Th1 responses by interacting with the CD3ζ-ZAP70 complex following Mycobacterium tuberculosis infection

Wu¹,

Wu²,

Ming³

et al. 2021

Journal of Clinical Investigation

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Section: Discussionsupporting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

TREM-2 promotes Th1 responses by interacting with the CD3ζ-ZAP70 complex following Mycobacterium tuberculosis infection

Wu¹,

Wu²,

Ming³

et al. 2021

Journal of Clinical Investigation

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“…We previously reported that TREM-1 was expressed on innate lymphocyte Vδ2T cells and activated the antigen presentation activity of Vδ2T cells to enhance T H 1 response in TB ( 24 ). In addition, TREM-2 expression was reported to be induced on peripheral blood CD4 + and CD8 + T cells in patients with TB ( 26 ). In this study, we demonstrated that TREM-2 was inducibly expressed on T cells in response to SARS-CoV-2 infection and substantially elevated in patients with severe COVID-19.…”

Section: Discussionmentioning

confidence: 99%

TREM-2 is a sensor and activator of T cell response in SARS-CoV-2 infection

Wang

Yin

et al. 2021

Sci. Adv.

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“…Members of the TREM family have been shown to modulate cellular response to inflammatory, pathogenic stimuli, and mediate cellular crosstalk ( 12 ). Expression of TREM-1 on blood monocytes of TB patients was enhanced, and cell-associated TREM-2 expression was increased on monocytes and lymphocytes from TB patients ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

TLT2 Suppresses Th1 Response by Promoting IL-6 Production in Monocyte Through JAK/STAT3 Signal Pathway in Tuberculosis

Cao

Xiang

et al. 2020

Front. Immunol.

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The function of triggering receptor expressed on myeloid cell-like transcript 2 (TLT2) has not been characterized and their role in pulmonary tuberculosis (TB) remains unclear. In this study, we found that surface TLT2 was up-regulated in human monocytes of patients with active TB compared to healthy subjects. In vitro, TLT2 expression was induced in human monocyte cell line THP-1 cells after bacillus Calmette-Guérin (BCG) or Mycobacterium tuberculosis (Mtb) H37Rv infection. Knockdown of TLT2 by siRNA transfection suppressed IL-6 expression, whereas over-expression of TLT2 increased IL-6 production in THP-1 cells infected by H37Rv. TLT2 + CD14 + monocytes produced higher level of IL-6 compared to TLT2 − subset in active TB patients. Western blot and immunocoprecipitation revealed that TLT2 interacted with kinase JAK1/JAK2/Tyk2 to enhance STAT3 phosphorylation. Moreover, we showed that tyrosine residues 297 and 315 of TLT2 cytoplasmic domain were involved in STAT3 activation. In monocyte/CD4 + T cell co-culture assay, blockage of TLT2 fusion protein facilitated IFN-γ production by CD4 + T cells. Plate count assay showed that monocyte-mediated bacterial killing was promoted by TLT2 fusion protein. In vivo treatment with TLT-2 fusion protein reduced IL-6 production by macrophage but increased IFN-γ production by CD4 + T cell in H37Rv and BCG infected mice. Furthermore, TLT2 fusion protein attenuated inflammation, and reduced bacterial load in lung of infected mice. Together, these findings demonstrate that TLT2 negatively regulates Th1 response against mycobacterial infection, which promotes IL-6 production through JAK/STAT3 signal pathway.

show abstract

Soluble and cell-associated triggering receptor expressed on myeloid cells-1 and -2 in patients with pulmonary tuberculosis

Cited by 8 publications

References 10 publications

TREM-2 promotes Th1 responses by interacting with the CD3ζ-ZAP70 complex following Mycobacterium tuberculosis infection

TREM-2 promotes Th1 responses by interacting with the CD3ζ-ZAP70 complex following Mycobacterium tuberculosis infection

TREM-2 is a sensor and activator of T cell response in SARS-CoV-2 infection

TLT2 Suppresses Th1 Response by Promoting IL-6 Production in Monocyte Through JAK/STAT3 Signal Pathway in Tuberculosis

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