Soluble adhesion molecule profiling in preoperative infants with biliary atresia

Th-17 cells infiltrate the liver in human biliary atresia and are related to surgical outcome

“…A similar observation was made by Kobayashi et al in their study of 15 infants (40). Similarly, we showed (38) that raised sVCAM levels at the time of KPE were associated with a poorer outcome in a study of 61 infants and that post-operative elevation of a range of cell adhesion molecules and cytokines such (IL-2, interferon-, IL-4, IL-10, TNF and sICAM-1) was associated with an increased need for early transplantation (39).…”

“…Interestingly, we have found a two-fold difference in Th-17 counts between patients who failed to achieve a normal bilirubin level post-KPE and those who did. However, just as the cause of biliary atresia can be heterogenous, so the response to the KPE is also multifactorial and caution should be exerted in the interpretation of a single observation, particularly when cellular in nature (13,38,29). In our previous immunohistochemical studies we reported that a liver infiltrate characterized by lower numbers of macrophages (CD68+) at the time of surgery was correlated to better outcomes at one year in 28 children with BA (13).…”

Serial circulating markers of inflammation in biliary atresia—Evolution of the post-operative inflammatory process

“…Baseline levels of both sICAM-1 and sVCAM-1 were more constrained and elevated compared to controls and in the case of sICAM-1, other cholestatic infants. Our previous cross-sectional study 2 had shown a positive correlation of sICAM-1 with age at KP (seen only with TNF␣ in this study), suggesting some relationship with the degree of inate liver disease. It is not really clear whether the inflammatory process seen in BA is specific or related in some way to neonatal cholestasis per se.…”

“…1,3,4 There is also abnormally increased expression of cellular adhesion molecules (CAMs) such as intercellular adhesion molecule (ICAM, CD54), vascular cell adhesion molecule (VCAM, CD106) and E-Selectin (CD62E) on both biliary and vascular endothelium. [1][2][3][4][5] We have also shown abnormally high levels of circulating soluble adhesion molecules (sICAM-1 and sVCAM-1) at the time of Kasai portoenterostomy (KP), with the former having a significant positive correlation with post-natal age and the latter prognostic significance when elevated (Ͼ1380 ng/ml). 2 The aim of this study was to follow the course of the inflammatory process as expressed by levels of soluble cellular adhesion molecules (CAMs) and cytokines into the early post-operative phase of this disease.…”

“…[1][2][3][4][5] We have also shown abnormally high levels of circulating soluble adhesion molecules (sICAM-1 and sVCAM-1) at the time of Kasai portoenterostomy (KP), with the former having a significant positive correlation with post-natal age and the latter prognostic significance when elevated (Ͼ1380 ng/ml). 2 The aim of this study was to follow the course of the inflammatory process as expressed by levels of soluble cellular adhesion molecules (CAMs) and cytokines into the early post-operative phase of this disease. A range of inflammatory molecules was studied including interleukin (IL) …”