Solubilized curcuminoid complex prevents extensive immunosuppression through immune restoration and antioxidant activity: Therapeutic potential against SARS-CoV-2 (COVID-19)

Kim, Woo Sik; Jeong, Seong‐Jae; Shin, Ki-Won; Lee, Hyeon Jin; Park, Jiyoung; Lee, In-Chul; Jeong, Hyung Jae; Ryu, Young Bae; Kwon, Hyung Jun; Lee, Woo Song

doi:10.1016/j.intimp.2022.109635

Cited by 4 publications

(3 citation statements)

References 62 publications

(75 reference statements)

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“…In an in-vitro study, preincubating immune cells from peripheral blood mononuclear cells (PBMCs) of donors with a history of COVID-19 and uninfected donors with tempol, a novel antioxidant, led to a decrease in different T-cell and APC-derived cytokines ( 78 ). In an immunosuppressive mouse model, a solubilized curcuminoid complex was found to lower the levels of neutrophils, dendritic cells, natural killer cells, CD4 + T cells, and CD8 + T cells in the spleen ( 79 ).…”

Section: Effect Of Antioxidant Molecules On Sars-cov-2mentioning

confidence: 99%

Novel antioxidant protein target therapy to counter the prevalence and severity of SARS-CoV-2

Kaur,

Dey,

Rawat

et al. 2024

Front. Immunol.

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BackgroundThis review analyzed the magnitude of the COVID-19 pandemic globally and in India and the measures to counter its effect using natural and innate immune booster molecules. The study focuses on two phases: the first focuses on the magnitude, and the second on the effect of antioxidants (natural compounds) on SARS-CoV-2.MethodsThe magnitude of the prevalence, mortality, and comorbidities was acquired from the World Health Organization (WHO) report, media, a report from the Ministry of Health and Family Welfare (MoHFW), newspapers, and the National Centre of Disease Control (NCDC). Research articles from PubMed as well as other sites/journals and databases were accessed to gather literature on the effect of antioxidants.ResultsIn the elderly and any chronic diseases, the declined level of antioxidant molecules enhanced the reactive oxygen species, which in turn deprived the immune system.ConclusionInnate antioxidant proteins like sirtuin and sestrin play a vital role in enhancing immunity. Herbal products and holistic approaches can also be alternative solutions for everyday life to boost the immune system by improving the redox balance in COVID-19 attack. This review analyzed the counteractive effect of alternative therapy to boost the immune system against the magnitude of the COVID-19 pandemic.

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Section: Effect Of Antioxidant Molecules On Sars-cov-2mentioning

confidence: 99%

Novel antioxidant protein target therapy to counter the prevalence and severity of SARS-CoV-2

Kaur,

Dey,

Rawat

et al. 2024

Front. Immunol.

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“…In this context, natural resources, due to their variety and peculiar richness in secondary metabolites, are currently objects of scientific and industrial interest. Among the countless vegetal species with formidable biological features, curcumin (CUR), the main components of curcuminoids, polyphenolic compounds found in the rhizomes of turmeric (Curcuma longa, Zingiberaceae family), is one of the natural compounds that have been extensively studied from a pharmacological perspective, and is well known as a spice and as a dye [ 6 , 7 ]. In the latest scientific literature, more than three thousand papers (source: WOS core collection, curcumin as keyword, years 2022–2023) testify the great interest in this natural compound.…”

Section: Introductionmentioning

confidence: 99%

“…The reasons for this considerable attention are the ascertained therapeutic efficacy in arthritis, liver, and neurodegenerative diseases; in several types of cancers, obesity, wound-healing, anti-inflammatory treatments; and as an antibacterial, antioxidant, antispasmodic, and anticoagulant agent [ 8 , 9 , 10 ]. In addition, recently, studies on CUR’s preventive effects on extensive immunosuppression are ongoing to investigate therapeutic potential against SARS-CoV-2 (COVID-19) [ 6 ]. In Figure 1 , the pharmacology benefits of curcumin are summarized.…”

Section: Introductionmentioning

confidence: 99%

A New Productive Approach and Formulative Optimization for Curcumin Nanoliposomal Delivery Systems

et al. 2023

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The use of natural resources and the enhancing of technologies are outlining the strategies of modern scientific-technological research for sustainable health products manufacturing. In this context, the novel simil-microfluidic technology, a mild production methodology, is exploited to produce liposomal curcumin as potential powerful dosage system for cancer therapies and for nutraceutical purposes. Through simil-microfluidic technology, based on interdiffusion phenomena of a lipid-ethanol phase in an aqueous flow, massive productions of liposomes at nanometric scale can be obtained. In this work, studies on liposomal production with useful curcumin loads were performed. In particular, process issues (curcumin aggregations) were elucidated and formulation optimization for curcumin load was performed. The main achieved result has been the definition of operative conditions for nanoliposomal curcumin production with interesting loads and encapsulation efficiencies.

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Immunomodulation by extracellular vesicle-like nanoparticles from marine macroalgae Sargassum fusiforme: Enhancing Type 1 T helper and cytotoxic T lymphocyte-mediated immune responses

Lee,

Shin,

Lee

et al. 2024

Journal of Functional Foods

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Solubilized curcuminoid complex prevents extensive immunosuppression through immune restoration and antioxidant activity: Therapeutic potential against SARS-CoV-2 (COVID-19)

Cited by 4 publications

References 62 publications

Novel antioxidant protein target therapy to counter the prevalence and severity of SARS-CoV-2

Novel antioxidant protein target therapy to counter the prevalence and severity of SARS-CoV-2

A New Productive Approach and Formulative Optimization for Curcumin Nanoliposomal Delivery Systems

Immunomodulation by extracellular vesicle-like nanoparticles from marine macroalgae Sargassum fusiforme: Enhancing Type 1 T helper and cytotoxic T lymphocyte-mediated immune responses

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