Solubilization of Poorly Water-Soluble Drugs Using Solid Dispersions

2019

Pharmaceutics

Despite many available approaches for transdermal drug delivery, patient compliance and drug targeting at the desired concentration are still concerns for effective therapies. Precise and efficient film-forming systems provide great potential for controlling drug delivery through the skin with the combined advantages of films and hydrogels. The associated disadvantages of both systems (films and hydrogels) will be overcome in film-forming systems. Different strategies have been designed to control drug release through the skin, including changes to film-forming polymers, plasticizers, additives or even model drugs in formulations. In the current review, we aim to discuss the recent advances in film-forming systems to provide the principles and review the methods of these systems as applied to controlled drug release. Advances in the design of film-forming systems open a new generation of these systems.

Section: Evaluation Of the Physico-chemical Properties Of Controllmentioning

confidence: 99%

Controlled Release Film Forming Systems in Drug Delivery: The Potential for Efficient Drug Delivery

2019

Pharmaceutics

“…NMR is another powerful technique that can be used to perform high sensitivity detection and obtain quantitative information at the molecular level [ 87 ]. In general, NMR monitors possible changes of electron density around specific interacting atoms to detect molecular interactions at the atomic level [ 88 , 89 ].…”

Section: Spectroscopic Techniques Used In the Investigation Of Molmentioning

confidence: 99%

Molecular Interactions in Solid Dispersions of Poorly Water-Soluble Drugs

2020

Pharmaceutics

Physicochemical characterization is a crucial step for the successful development of solid dispersions, including the determination of drug crystallinity and molecular interactions. Typically, the detection of molecular interactions will assist in the explanation of different drug performances (e.g., dissolution, solubility, stability) in solid dispersions. Various prominent reviews on solid dispersions have been reported recently. However, there is still no overview of recent techniques for evaluating the molecular interactions that occur within solid dispersions of poorly water-soluble drugs. In this review, we aim to overview common methods that have been used for solid dispersions to identify different bond formations and forces via the determination of interaction energy. In addition, a brief background on the important role of molecular interactions will also be described. The summary and discussion of methods used in the determination of molecular interactions will contribute to further developments in solid dispersions, especially for quick and potent drug delivery applications.

“…While an alternative structure of drug from crystalline to amorphous state may occur to improve the dissolution, an interaction among agents is another factor to contribute to the enhanced drug dissolution. Although molecular interaction between drug and polymer has been known as an important factor for improving dissolution rate [3,7,[16][17][18], there have been no studies through sonoprecipitation method indicating modulation of molecular interactions and its interesting effects on particle size for the control of drug dissolution rate in details.…”

Section: Introductionmentioning

confidence: 99%

Modulation of particle size and molecular interactions by sonoprecipitation method for enhancing dissolution rate of poorly water-soluble drug

Ultrasonics Sonochemistry

2015

Aim of present work was to originally elucidate the roles of ultrasonication method for modulating the size and molecular interactions in controlling release of poorly water-soluble drug. Curcumin was chosen as a model drug. Three types of polymers were investigated as carriers for preparation of polymeric nanoparticles under various ultrasonication conditions and polymer-drug ratios. Changes in drug crystallinity, particle size, and molecular interactions which would be factors enhancing drug dissolution rate were evaluated. Amorphous form of curcumin, size reduction of nanoparticles and interaction between drug and polymer in formulations were attributed to improved drug dissolution rate. Particle size was strongly affected by polymer type, polymer-drug ratio and ultrasonication conditions. Interestingly, control of those factors caused differences in molecular interactions of the hydroxyl groups and then, highly affected particle size of the nanoparticles. It was obvious that there was a reciprocal influence between the drug-polymer interactions and particle size of the nanoparticles. This relation could be modulated by polymers and ultrasonication processes for enhancing drug dissolution rate.