Solubilization of drugs using beta-cyclodextrin: Experimental data and modeling

Kaboudi, Navid; Asl, Saba Ghasemi; Nourani, Nasim; Shayanfar, Ali

doi:10.1016/j.pharma.2024.02.003

Cited by 2 publications

(3 citation statements)

References 80 publications

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“…Certain robots and technological advancements have demonstrated their potential in enhancing human health and augmenting our medical infrastructure (36)(37)(38). However, researchers should provide methods to measure the quality of health care services, because if it is not measured, health care services cannot be managed and improved (39)(40)(41). In our study most individuals had vitamin D deficiency and elevated levels of iPTH.…”

Section: Resultsmentioning

confidence: 99%

Serum 25(OH)D Levels and Mitral Valve Calcification in Patients with Severe Rheumatic Mitral Stenosis

Rahmani,

Kavoosi,

Sadeghi

et al. 2024

CJMS

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Background: Rheumatic heart disease (RHD) imposes a significant burden on patients and the health system, especially in the developing countries. Recently, the role of vitamin D deficiency in increasing the severity of valve involvement and calcification in patients with RHD has been suggested. However, its role in the severe stenosis of the mitral valve is unknown. The aim of this study was to determine the relationship between serum levels of 25(OH)D and mitral involvement severity scores in patients with severe mitral stenosis (MS). Materials and Methods: In this cross-sectional study conducted in Shahid Madani Heart Center, Tabriz, Iran, 104 patients with severe rheumatic MS were reviewed, in the absence of other underlying diseases. Trans-esophageal Echocardiography was performed for all patients, and mitral valve Wilkins score and mitral valve area were calculated. Blood samples were taken from patients and levels of 25(OH)D, total calcium, phosphorus, and i-PTH were measured. Results: Eighty eight cases were female and 16 were male. Eighty-one patients had mild to moderate mitral calcification and in 23 patients with mitral valve was severely calcified. Furthermore, 54 were vitamin D deficient, while 35 had insufficient vitamin D levels, and only 15 had normal blood levels of vitamin D. In addition high serum iPTH levels were present in 83 patients (80%). The levels of 25(OH)D, calcium, phosphorous, and iPTH with total Wilkins score, calcification score and mitral valve area were not significantly correlated (p>0.05 for all above). Conclusions: Although no correlation was found between the severity of mitral valve involvement, and vitamin D and iPTH levels, vitamin D deficiency and secondary hyperparathyroidism tend to be common among patients with severe rheumatic MS, which may play a role in the progression of the disease.

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Section: Resultsmentioning

confidence: 99%

Serum 25(OH)D Levels and Mitral Valve Calcification in Patients with Severe Rheumatic Mitral Stenosis

Rahmani,

Kavoosi,

Sadeghi

et al. 2024

CJMS

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“…In order to identify the mechanism of apoptosis induction by COMPOUND HONEY SYRUP, the level of activity of caspase 9 and : in AGS cancer cells was investigated and it was found that COMPOUND HONEY SYRUP increases the activity of both caspase 9 and :, but the increase in caspase : activity was much higher. Therefore, the mitochondrial pathway of apoptosis has a greater role in killing cells (31)(32)(33)1). Antioxidants are substances that are able to deal with the effects of the physiological process of oxidation in tissues.…”

Section: Discussionmentioning

confidence: 99%

“…Honey is one of the most widely used drugs in complementary medicine. Honey, which is one of the components of compound mead syrup, contains the flavonoid components of quercetin, kaempferol, apigenin and genistein (2:) and phenolic components, and this group of flavonoids in honey is also considered as a pharmacological stimulator of CFTR (31). One hypothesis is that honey, due to the abundance of polyphenolic flavonoids, leads to the inhibition of P-glycoprotein, which is one of the transfer proteins in multi-drug resistance (MDR) organisms (32).…”

Section: Introductionmentioning

confidence: 99%

Investigating the Anticancer Effect of Compound Honey Syrup Herbal Product on Gastric Adenocarcinoma Cells

Mehrabkhani,

Fallah,

Lohrasb

et al. 2024

CJMS

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Introduction: Apoptosis has provided solutions for effective anticancer treatments, and today one of the most interesting strategies is drug interventions that can mediate the death of cancer cells through the induction of apoptosis. Many plant compounds are known to have anti-tumor activity in this way. Compound Honey Syrup is used in Iranian traditional medicine and its cytotoxicity has been determined on melanoma cells. The purpose of this research was to investigate the anticancer effect of Compound Honey Syrup herbal product on gastric adenocarcinoma cells and the mechanism of this effect. Method: The lethal effect of Compound Honey Syrup on gastric adenocarcinoma (AGS) and fibroblastic (HgF) cells after 24 hours of incubation was investigated by MTT calorimetric method. Annexin FITC-V and PI staining method determined apoptotic cell death. The change in the activity of caspases 8 and 9 was also evaluated by enzymatic method. The base membrane of the model was used to evaluate the invasion ability of Compound Honey Syrup cancer cells. Results: Compound Honey Syrup had a strong and concentration-dependent killing effect on AGS cells and caused cell death mainly by inducing early apoptosis. The increased activity of caspases 8 and 9 was involved in this process. Compound Honey Syrup also reduced the ability of cancer cells to invade. Conclusion: By activating caspases 8 and 9, COMPOUND HONEY SYRUP led to the apoptotic death of human gastric cancer cells. In addition, COMPOUND HONEY SYRUP can be an effective factor for investigating the prevention or treatment of stomach cancer in humans by reducing the strength and invasion of cancer cells.

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Solubilization of drugs using beta-cyclodextrin: Experimental data and modeling

Cited by 2 publications

References 80 publications

Serum 25(OH)D Levels and Mitral Valve Calcification in Patients with Severe Rheumatic Mitral Stenosis

Serum 25(OH)D Levels and Mitral Valve Calcification in Patients with Severe Rheumatic Mitral Stenosis

Investigating the Anticancer Effect of Compound Honey Syrup Herbal Product on Gastric Adenocarcinoma Cells

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