Solubility studies on the system of trihexyl(tetradecyl)phosphonium bis[(trifluoromethyl)sulfonyl]amide) ionic liquid and pharmaceutical and bioactive compounds

Faria, Ricardo A.; Ponte, Manuel Nunes da; Bogel‐Łukasik, Ewa

doi:10.1016/j.fluid.2014.10.033

Cited by 20 publications

(14 citation statements)

References 33 publications

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“…A detailed version of the calculations performed are described in previous papers. 7,18,32 Like in previous studies, six equations were provided to derive the solute activity coefficients γ 1 from the so-called correlation equations that describe the Gibbs excess energy (G E ), the Wilson, 55 UNIQUAC, 56 UNIQUAC ASM, 57 NRTL, 58 NRTL1 59 and NRTL2 59 according to the mathematical equations described already in detail. 60 The γ 1 present in Tables 3 and 4 were calculated by the models with the lowest standard deviation, which are present in Table 5.…”

Section: Correlation Equations Of Slementioning

confidence: 99%

Solubility Data as a Response for a Challenge for Formulation Chemists: Imidazolium-Based Ionic Liquids and Antitubercular Antibiotic Medicines

et al. 2016

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The evolution of technology is directed to reduce industrial waste from chemical processes to zero. In the past decade interest in ionic liquids (ILs) has grown, and they have been recognized as potential substitutes for volatile organic solvents used in certain chemical processes, including those in the pharmaceutical industry. Following this increasing interest and because ILs can have a great potential for the pharmaceutical industry, we tested the solubility of two antitubercular medicines, pyrazinecarboxamide and isoniazid, in imidazolium ionic liquids, namely [C4mim][BF4], [C4mim][PF6], [C4mim][OTf], and [C8mim][OTf], in the range of 279.98 to 417.05 K. Both drugs exhibited an improved solubility in [C4mim][BF4] than in the other studied ILs. The solutes had an enhanced solubility in more hydrophilic ILs, such as [C4mim][BF4] and [C4mim][PF6]. The solubility decreased in ILs containing the hydrophobic anion trifluoromethanesulfonate and with the increasing alkyl chain length in the cation. The solid–liquid phase equilibria of all investigated systems were described using six different correlation equations. The satisfactory results which revealed a good description with an acceptable standard deviation temperature range were collected for isoniazid or pyrazinecarboxamide in [C4mim][PF6], [C4mim][OTf] and [C8mim][OTf]. Comparison to solubility in NTf2 and [C10mim][OTf] was provided.

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Section: Correlation Equations Of Slementioning

confidence: 99%

Solubility Data as a Response for a Challenge for Formulation Chemists: Imidazolium-Based Ionic Liquids and Antitubercular Antibiotic Medicines

et al. 2016

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“…TQ has a melting point of 43·5°C and is hydrophobic, and its solubility decreases as the temperature decrease (Faria et al . ).…”

Section: Discussionmentioning

confidence: 97%

“…The increased antimicrobial activity of TQ at higher temperature may be partially explained by higher solubility in the reconstituted formula. TQ has a melting point of 43Á5°C and is hydrophobic, and its solubility decreases as the temperature decrease (Faria et al 2015).…”

Section: Discussionmentioning

confidence: 99%

Inactivation of Cronobacter sakazakii in reconstituted infant formula by combination of thymoquinone and mild heat

et al. 2015

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“…Thymoquinone -[P666( 14)][NTf2] 0.1105 a [72] a: molar fraction; b: mg mL −1 ; c: mmol L −1 ; d: mg g −1 . * Solubility determined at body's temperature (34-38 °C).…”

Section: Apimentioning

confidence: 99%

The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications

Pedro

Freire

Silvestre

et al. 2020

IJMS

132

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Solubility, bioavailability, permeation, polymorphism, and stability concerns associated to solid-state pharmaceuticals demand for effective solutions. To overcome some of these drawbacks, ionic liquids (ILs) have been investigated as solvents, reagents, and anti-solvents in the synthesis and crystallization of active pharmaceutical ingredients (APIs), as solvents, co-solvents and emulsifiers in drug formulations, as pharmaceuticals (API-ILs) aiming liquid therapeutics, and in the development and/or improvement of drug-delivery-based systems. The present review focuses on the use of ILs in the pharmaceutical field, covering their multiple applications from pharmaceutical synthesis to drug delivery. The most relevant research conducted up to date is presented and discussed, together with a critical analysis of the most significant IL-based strategies in order to improve the performance of therapeutics and drug delivery systems.

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Solubility studies on the system of trihexyl(tetradecyl)phosphonium bis[(trifluoromethyl)sulfonyl]amide) ionic liquid and pharmaceutical and bioactive compounds

Cited by 20 publications

References 33 publications

Solubility Data as a Response for a Challenge for Formulation Chemists: Imidazolium-Based Ionic Liquids and Antitubercular Antibiotic Medicines

Solubility Data as a Response for a Challenge for Formulation Chemists: Imidazolium-Based Ionic Liquids and Antitubercular Antibiotic Medicines

Inactivation of Cronobacter sakazakii in reconstituted infant formula by combination of thymoquinone and mild heat

The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications

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