Solubility of Valsartan in Different Organic Solvents and Ethanol + Water Binary Mixtures from (278.15 to 313.15) K

Abstract

The solubility of valsartan in pure methyl acetate, n-butyl acetate, acetonitrile, N,N-dimethylformamide, dichloromethane, chloroform, and ethanol + water binary mixtures was measured by a synthetic method over the temperature range (278.15 to 313.15) K at atmospheric pressure. The results show that the solubility of valsartan increases with increasing temperature in all six pure solvents and ethanol + water binary mixtures, and it increases with increasing mole fraction of ethanol in the binary mixtures. The experimental data were correlated using the modified Apelblat model, and the agreement with the experimental data was very good.

Solubility in Different Solvents, Crystal Polymorph and Morphology, and Optimization of Crystallization Process of AIBN

“…Eq. 3 represents the modified Apelblat equation, which is a semi-empirical model with the following expression [6][7][8] :…”

“…Eq represents the modified Apelblat equation, which is a semiempirical model with the following expression: − where x A is the mole fraction solubility, T is the absolute temperature, and A , B and C are empirical constants.…”

Solubility of Artemisinin in Different Single and Binary Solvent Mixtures Between (284.15 and 323.15) K and NRTL Interaction Parameters

“…For this reason, solubilities for a wide range of pharmaceutical and drug compounds have been measured in different solvents and reported in the literature. [1][2][3][4][5][6][7][8] Artemisinin, known in Chinese as Qinghaosu, is an important bioactive component in Artemisia annua leaves and flowers, which has been used as a traditional Chinese medicine in the treatment of fever for a long time. 9 The compound is a sesquiterpene lactone endoperoxide (shown in Figure 1), and a number of its precursors, metabolites, and semisynthetic derivatives have recently been shown to possess antimalarial properties.…”

“…Therefore, a rapid and reliable method for measuring solubility of drug compounds is needed for design and optimization of cost-effective manufacturing processes. For this reason, solubilities for a wide range of pharmaceutical and drug compounds have been measured in different solvents and reported in the literature. − …”

Solubility of Scutellarin in Methanol, Water, Ethanol, and Ethanol + Water Binary Mixtures from (293.2 to 333.2) K

“…Figure shows the calculated solubility of scutellarin at different temperatures with the experimental values. The composition of the binary ethanol + water solvent mixtures, x 1 , is defined as eq x 1 = m B / M B m B / M B + m C / M C …”