Solubility of Sucralose in Different Solvents from (283.15 to 333.15) K

Li, Xin; Du, Zhenxing; Huang, Xiaoquan; Yuan, Wei; Ying, Hanjie

doi:10.1021/je9008427

Cited by 14 publications

(7 citation statements)

References 9 publications

(13 reference statements)

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“…These particular solvents are often used to extract lipid components from mixtures ( Ramesh et al, 1979 ; Goldsmith et al, 1988 ; Mao-Qiang et al, 1996 ; Cabrini et al, 1992 ; Crabbe et al, 2001 ; Lin et al, 2004 ). The fact that sucralose is readily soluble in alcohols was corroborated by others ( Bennett et al, 1992 ; Anderson et al, 2006 ; Li et al, 2010 ).…”

Section: Potential Toxicity From Habitual Sucralose Ingestionsupporting

confidence: 60%

“…The decrease in the concentration of a xenobiotic compound as it passes through the GIT and liver is termed the “first-pass effect” ( Riegelman and Rowland, 1973 ; Iwamoto and Klaassen, 1977 ; Shimomura et al, 2002 ; Watkins, 1997 ; Paine and Thummel, 2003 ; Paine, 2009 ). The intestinal component of the first-pass effect is especially significant in the disposition of sucralose because the majority of this OC sweetener is reportedly unabsorbed from the small intestine after ingestion ( Grice and Goldmith, 2000 ) even though it is an amphiphilic compound with appreciable lipid solubility ( Hough and Khan, 1978 ; 1989 ; Anderson et al, 2006 ; Li et al, 2010 ). Further, higher doses of orally administered sucralose in humans are associated with lower urinary excretion that suggests sucralose absorption is reduced at increased concentrations ( Roberts et al, 2000 ).…”

Section: Effects Of Sucralose On Presystemic Detoxification Mechanismmentioning

confidence: 99%

“…The range of product utilization is more extensive for sucralose than for other artificial sweeteners due to its physicochemical properties. For example, sucralose is readily soluble in ethanol, methanol, and water ( Bennett et al, 1992 ; Anderson et al, 2006 ; Merck Index, 2006; Li et al, 2010 ), and this solubility profile contributes to its versatility in both fat- and water-based food and beverage applications including alcoholic drinks. Other common artificial sweeteners such as aspartame, sodium saccharin, and acesulfame-potassium (ace-K) are only slightly or sparingly soluble in ethanol and / or methanol ( Schiffman and Gatlin, 1993 ; Merck Index, 2006) and have more limited product applications.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Sucralose, A Synthetic Organochlorine Sweetener: Overview Of Biological Issues

Schiffman

Rother

2013

Journal of Toxicology and Environmental Health, Part B

135

107

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Sucralose is a synthetic organochlorine sweetener (OC) that is a common ingredient in the world's food supply. Sucralose interacts with chemosensors in the alimentary tract that play a role in sweet taste sensation and hormone secretion. In rats, sucralose ingestion was shown to increase the expression of the efflux transporter P-glycoprotein (P-gp) and two cytochrome P-450 (CYP) isozymes in the intestine. P-gp and CYP are key components of the presystemic detoxification system involved in first-pass drug metabolism. The effect of sucralose on first-pass drug metabolism in humans, however, has not yet been determined. In rats, sucralose alters the microbial composition in the gastrointestinal tract (GIT), with relatively greater reduction in beneficial bacteria. Although early studies asserted that sucralose passes through the GIT unchanged, subsequent analysis suggested that some of the ingested sweetener is metabolized in the GIT, as indicated by multiple peaks found in thin-layer radiochromatographic profiles of methanolic fecal extracts after oral sucralose administration. The identity and safety profile of these putative sucralose metabolites are not known at this time. Sucralose and one of its hydrolysis products were found to be mutagenic at elevated concentrations in several testing methods. Cooking with sucralose at high temperatures was reported to generate chloropropanols, a potentially toxic class of compounds. Both human and rodent studies demonstrated that sucralose may alter glucose, insulin, and glucagon-like peptide 1 (GLP-1) levels. Taken together, these findings indicate that sucralose is not a biologically inert compound.

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Section: Potential Toxicity From Habitual Sucralose Ingestionsupporting

confidence: 60%

Section: Effects Of Sucralose On Presystemic Detoxification Mechanismmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Sucralose, A Synthetic Organochlorine Sweetener: Overview Of Biological Issues

Schiffman

Rother

2013

Journal of Toxicology and Environmental Health, Part B

135

107

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“…Because the analyses were performed on a set of sample extracts archived for 36–48 months at −80 °C, there are concerns with sample integrity during long-term storage. Sucralose has been shown to be a relatively inert and stable molecule, and is known to be very soluble in the storage solvent, methanol . There were several duplicate samples collected throughout the study for source, finished drinking and distribution water.…”

Section: Resultsmentioning

confidence: 99%

Artificial Sweetener Sucralose in U.S. Drinking Water Systems

Mawhinney

Young

Vanderford

et al. 2011

Environ. Sci. Technol.

185

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The artificial sweetener sucralose has recently been shown to be a widespread of contaminant of wastewater, surface water, and groundwater. In order to understand its occurrence in drinking water systems, water samples from 19 United States (U.S.) drinking water treatment plants (DWTPs) serving more than 28 million people were analyzed for sucralose using liquid chromatography tandem mass spectrometry (LC-MS/MS). Sucralose was found to be present in source water of 15 out of 19 DWTPs (47-2900 ng/L), finished water of 13 out of 17 DWTPs (49-2400 ng/L) and distribution system water of 8 out of the 12 DWTPs (48-2400 ng/L) tested. Sucralose was only found to be present in source waters with known wastewater influence and/or recreational usage, and displayed low removal (12% average) in the DWTPs where finished water was sampled. Further, in the subset of DWTPs with distribution system water sampled, the compound was found to persist regardless of the presence of residual chlorine or chloramines. In order to understand intra-DWTP consistency, sucralose was monitored at one drinking water treatment plant over an 11 month period from March 2010 through January 2011, and averaged 440 ng/L in the source water and 350 ng/L in the finished water. The results of this study confirm that sucralose will function well as an indicator compound for anthropogenic influence on source, finished drinking and distribution system (i.e., tap) water, as well as an indicator compound for the presence of other recalcitrant compounds in finished drinking water in the U.S.

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“…For example, it is used to help improve adherence to medication by masking the bitter taste of drugs and is used in personal hygiene products such as toothpaste and mouthwashes (Gupta et al, 2012;Budanur et al, 2016). The range of products utilising sucralose is larger than most other artifical sweeteners mainly due to its physico-chemical properties (see Section 6.4), in particular its solubility in both water and alcohol (Bennett et al, 1992;Anderson et al, 2006;Li et al, 2010) which enables its use in both fat-and water-based food and beverage applications including alcoholic drinks. This is in contrast to other common artificial sweeteners such as aspartame, saccharin, and acesulfame-K that are only slightly soluble in alcohol (O'Neal, 2006) and so have more limited product applications.…”

Section: Introductionmentioning

confidence: 99%

Review and synthesis of data on the potential environmental impact of artificial sweeteners

Lewis

Tzilivakis

2021

EFSA Supporting Publications

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EFSA is implementing evidence-based risk assessments for the re-evaluation of certain sweeteners. The aim of this work was to ensure that, as part of the preparatory work done by EFSA to support its Panel on Food Additives and Flavourings (FAF) in reaching conclusions on the safety of permitted food additives, relevant information on the environmental risks associated with the use of the artificial sweeteners are identified. In the context of this re-evaluation process the following substances used as sweeteners were considered: acesulfame-K (E 950), salt of aspartame-acesulfame (E 962), sucralose (E 955), saccharins (E 954), thaumatin (E 957), neohesperidine DC (E 959), neotame (E 961), cyclamates (E 952) and the polyol sweeteners (sorbitols (E 420); mannitol (E 421); isomalt (E 953); maltitols (E 965); lactitol (E 966); xylitol (E 967) and erythritol (E 968)). Data was collated using a systematic review approach. Generally, the data identified was extremely limited particularly with respect to neohesperidine DC, neotame, thaumatin and the polyol sweeteners. However, there was also limited evidence to suggest their widespread occurrence in the environment. With respect to acesulfame-K, sucralose, cyclamates and saccharin multiple studies were identified that demonstrate the widespread distribution of these sweeteners in surface waters, groundwaters, coastal and marine waters. There are also studies showing their presence in drinking (tap) water supplies, rainwater and in atmospheric samples. However, these sweeteners do not appear to be highly toxic to aquatic species, at least not at environmental concentrations currently seen. The salt of aspartame-acesulfame easily dissociates into its two component sweeteners in the human body and the environment and so the review process also considered aspartame despite it not being a specific focus of the regulatory review process. Whilst there is some evidence to suggest aspartame is toxic to aquatic species it is not detected at levels of concern in the environment.

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Solubility of Sucralose in Different Solvents from (283.15 to 333.15) K

Cited by 14 publications

References 9 publications

Sucralose, A Synthetic Organochlorine Sweetener: Overview Of Biological Issues

Sucralose, A Synthetic Organochlorine Sweetener: Overview Of Biological Issues

Artificial Sweetener Sucralose in U.S. Drinking Water Systems

Review and synthesis of data on the potential environmental impact of artificial sweeteners

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