Solubility of Potassium Clavulanate in Ethanol, 1-Propanol, 1-Butanol, 2-Propanol, and 2-Methyl-1-propanol between 273 K and 305 K

Liu, Bao‐Shu; Gong, Junbo; Wang, Jingkang; Jia, Chunyan

doi:10.1021/je050145r

Cited by 46 publications

(59 citation statements)

References 8 publications

(7 reference statements)

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“…The partition coefficient ( K ) and recovery yield ( Y ) of CA increased with the hydrophilicity of the organic solvent. This result was similar to a reported study [37], in which the solubility of CA in its potassium salt form ranked in the following order: ethanol > 1‐propanol > 1‐butanol > 2‐propanol > 2‐methyl‐1‐propanol. Since CA exists in the dissociation form when the system pH > 2.3 [5, 6], hydrophobic organic solvents such as ethyl acetate had the difficulty in the extracting of CA into the top phase at these screened systems with pH range of 6–8 (Table 1).…”

Section: Resultssupporting

confidence: 92%

Simultaneous solid–liquid separation and primary purification of clavulanic acid from fermentation broth of Streptomyces clavuligerus using salting‐out extraction system

Wang

Qin

et al. 2021

Engineering in Life Sciences

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Clavulanic acid (CA) is usually used together with other β‐lactam antibiotics as combination drugs to inhibit bacterial β‐lactamases, which is mainly produced from the fermentation of microorganism such as Streptomyces clavuligerus. Recently, it is still a challenge for downstream processing of low concentration and unstable CA from fermentation broth with high solid content, high viscosity, and small cell size. In this study, an integrated process was developed for simultaneous solid–liquid separation and primary purification of CA from real fermentation broth of S. clavuligerus using salting‐out extraction system (SOES). First, different SOESs were investigated, and a suitable SOES composed of ethanol/phosphate was chosen and further optimized using the pretreated fermentation broth. Then, the optimal system composed of 20% ethanol/15% K2HPO4 and 10% KH2PO4 w/w was used to direct separation of CA from untreated fermentation broth. The result showed that the partition coefficient (K) and recovery yield (Y) of CA from untreated fermentation broth were 29.13 and 96.8%, respectively. Simultaneously, the removal rates of the cells and proteins were 99.8% and 63.3%, respectively. Compared with the traditional method of membrane filtration or liquid–liquid extraction system, this developed SOES showed the advantages of simple operation, shorter operation time, lower process cost and higher recovery yield of CA. These results demonstrated that the developed SOES could be used as an attractive alternative for the downstream processing of CA from real fermentation broth.

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Section: Resultssupporting

confidence: 92%

Simultaneous solid–liquid separation and primary purification of clavulanic acid from fermentation broth of Streptomyces clavuligerus using salting‐out extraction system

Wang

Qin

et al. 2021

Engineering in Life Sciences

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“…Therefore, the calculated values of it were fitted with the experimental solubility. 31 Also, the LTG temperature dependence of the solubility is shown by eq S-6, where A, B, and C indicate empirical constants. The values of A and B demonstrate the variation of the solution activity coefficient, and the C value shows the temperature effect on the enthalpy of fusion.…”

Section: The E-nrtl Activity Coefficient Modelmentioning

confidence: 99%

“…To demonstrate the substance polar and nonpolar behavior, the modified Apelblat equation has been applied as the mathematical model. Therefore, the calculated values of it were fitted with the experimental solubility . Also, the LTG temperature dependence of the solubility is shown by eq S-6, where A , B , and C indicate empirical constants.…”

Section: Thermodynamic Representation Of Experimental Datamentioning

confidence: 99%

Measurement and Thermodynamic Modeling of Lamotrigine Solubility in the Presence of Some Choline-Based Ionic Liquids

et al. 2021

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Choline chloride-based ionic liquids (ILs) have recently received a great deal of attention in many fields of science. In this regard, the mole fraction solubility data of lamotrigine (LTG) in the presence of three choline-based ILs were measured from 298.15 to 313.15 K. The LTG is known as an antiepileptic anticonvulsant or antiepileptic drug. This drug has few side effects in comparison to other drugs, and it has a slightly delayed onset of action because of the poor aqueous solubility of LTG (0.187 g/L at 298.15 K). The used ILs (choline glycinate [Ch][Gly], choline alaninate [Ch][Ala], and choline bitartrate [Ch][Bitar]) increased the drug aqueous solubility. Based on the results of solubility studies, it was clear that [Ch][Gly] has a more pronounced effect on LTG solubility enhancement as compared to the two other ILs. Also, in binary solvent systems (ILs and water), the solubility values increased with the rise of temperature. Analysis of the data showed that the solubility behavior was influenced by some properties, including the polarity, hydrogen bonds, cohesive energy density, and molecular structures. The measured data were fitted to some applicable models. The performance of the used models according to %ARD is e-NRTL (0.66%) > Wilson (4.04%) > Jouyban−Acree (5.59%) > Yalkowsky (5.73%) > Apelblat (5.78%). Additionally, the apparent thermodynamic properties of the dissolution process, including the Gibbs energy, enthalpy, and entropy, were calculated using the van't Hoff and Gibbs equations. The results showed that the dissolution process is an endothermic process and enthalpy-driven in all applied cosolvents. The solubility data for LTG in these neoteric green solvents can be widely used in the pharmaceutical sciences.

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“…The solubilities of HPGDane Salt in the mixture of methanol and ethanol at different temperatures are shown in Table 1. The relationship between temperature and solubility of the HPGDane Salt is correlated with a semiempirical equation: 8 where T is the absolute temperature, and a, b, and c are empirical * To whom correspondence should be addressed. E-mail: wangshui2000@ sohu.com.…”

Section: Resultsmentioning

confidence: 99%

Solubility ofd-(-)-p-Hydroxyphenylglycine Dane Salt in Mixtures of Methanol and Ethanol

Liu

Wang

2006

J. Chem. Eng. Data

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Solubility of Potassium Clavulanate in Ethanol, 1-Propanol, 1-Butanol, 2-Propanol, and 2-Methyl-1-propanol between 273 K and 305 K

Cited by 46 publications

References 8 publications

Simultaneous solid–liquid separation and primary purification of clavulanic acid from fermentation broth of Streptomyces clavuligerus using salting‐out extraction system

Simultaneous solid–liquid separation and primary purification of clavulanic acid from fermentation broth of Streptomyces clavuligerus using salting‐out extraction system

Measurement and Thermodynamic Modeling of Lamotrigine Solubility in the Presence of Some Choline-Based Ionic Liquids

Solubility ofd-(-)-p-Hydroxyphenylglycine Dane Salt in Mixtures of Methanol and Ethanol

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