Solubility of oxcarbazepine in eight solvents within the temperature range T = (288.15–308.15) K

Nam, Ki Woong; Ha, Eun Sol; Kim, Jeong Soo; Kuk, Do Hoon; Ha, Dong Hyeon; Kim, Min Soo; Cho, Cheong-Weon; Hwang, Sung Joo

doi:10.1016/j.jct.2016.09.011

Cited by 18 publications

(8 citation statements)

References 13 publications

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“…The Apelblat model, as a frequently used semiempirical equation, was used to represent the solubility against temperature. − The model can be applied in both monosolvents and mixed solvents. The expression is as follows: where T is the absolute temperature; x is the solubility of imatinib mesylate in solvents; and A , B , and C are semiempirical constants.…”

Section: Thermodynamic Modelsmentioning

confidence: 99%

Thermodynamic Study of Solubility for Imatinib Mesylate in Nine Monosolvents and Two Binary Solvent Mixtures from 278.15 to 318.15 K

et al. 2018

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The solubility of imatinib mesylate in nine monosolvents and two binary solvents was determined by the shaken flask method followed by UV composition analysis from 278.15 to 318.15 K at atmospheric pressure. The solubility increases with the increasing of temperature in all solvents we chose. Meanwhile, the dissolving capacity of imatinib mesylate ranks as methyl acetate < 2-propanol < acetonitrile < isobutanol < 1-butanol < tetrahydrofuran < 1-propanol < ethanol < methanol. The Apelblat model, λh equation, and nonrandom two-liquid (NRTL) model described the solubility data of imatinib mesylate in monosolvents; simultaneously, the Apelblat model, combined nearly ideal binary solvent/Redlich-Kister model, and NRTL model were employed in binary solvents. The results show a satisfactory correlation with the experimental data. Additionally, mixing thermodynamic properties of imatinib mesylate were calculated based on the NRTL model, which reveals the mixing process is spontaneous and exothermic.

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Section: Thermodynamic Modelsmentioning

confidence: 99%

Thermodynamic Study of Solubility for Imatinib Mesylate in Nine Monosolvents and Two Binary Solvent Mixtures from 278.15 to 318.15 K

et al. 2018

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“…The modified Apelblat equation is a commonly used model in solubility correlation based on nonideal solution. The mole fraction solubility as a function of temperature at the same solvent composition can be correlated by the modified Apelblat equation, − expressed as follows where x 1 is the mole fraction solubility of the solute; A , B , and C are the model parameters regressed from the experimental data; and T is the absolute temperature in K. The values of the model parameters are listed in Tables S2 and S4.…”

Section: Results and Discussionmentioning

confidence: 99%

Solubility of l-Phosphinothricin and Its Hydrochloride in Water + (Methanol and Ethanol) Binary Solvent Mixtures from 278.15 to 318.15 K

et al. 2019

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The solubility of l-phosphinothricin (l-PPT) and its hydrochloride in water + (methanol and ethanol) binary solvent mixtures was experimentally measured from 278.15 to 318.15 K by a static analytic method under atmospheric pressure. The experimental data showed that the solubility increased with the increasing temperature and decreased with the increase of alcohol concentration in binary solvent mixtures. The experimental data were correlated by the modified Apelblat equation and combined nearly ideal binary solvent/Redlich–Kister model. The results indicated that the modified Apelblat equation showed better agreement with the experimental data. The parameters characterizing preferential solvation of l-PPT in water + methanol binary solvents had been calculated. The results showed that the preferential solvation of l-PPT was related to the solvent composition and temperature.

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“…A modified Apelblat model is a semi-empirical one, which was first proposed by Apelblat et al This model describes the solubility of a solute as a function of temperature. − The mathematical expression is as eq where x 1 is the solubility of solute in mole fraction; T is the temperature; A , B , and C are the adjustable model parameters.…”

Section: Thermodynamic Modelsmentioning

confidence: 99%

Solubility Determination and Thermodynamic Properties of Bezafibrate in Pure and Binary Mixed Solvents

Liu

Wang

Qu³

et al. 2020

J. Chem. Eng. Data

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In this work, the solubility of bezafibrate in 16 pure solvents including 9 alcohols (methanol, ethanol, n-propanol, iso-propanol, n-butanol, iso-butanol, sec-butanol, 1-pentanol, and iso-pentanol), 4 alkyl acetate (ethyl acetate, n-propyl acetate, n-butyl acetate, and methyl propionate), 2 ketones (methyl ethyl ketone and cyclohexanone) and one nitrile (acetonitrile) and in binary mixed solvents (methanol + acetonitrile) at temperature of 283.15–323.15 K was determined. The solubility of bezafibrate in pure solvents was simulated using modified Apelblat, Van’t Hoff, Wilson, and NRTL model. That in binary mixed solvents was simulated using the modified Apelblat and Apelblat–Jouyban–Acree model. The thermodynamic mixing properties (Δmix G, Δmix H, Δmix S, γ1 ∞, and H 1 E,∞) of the bezafibrate-pure solvent systems were evaluated based on the solubility data and Wilson model.

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Solubility of oxcarbazepine in eight solvents within the temperature range T = (288.15–308.15) K

Cited by 18 publications

References 13 publications

Thermodynamic Study of Solubility for Imatinib Mesylate in Nine Monosolvents and Two Binary Solvent Mixtures from 278.15 to 318.15 K

Thermodynamic Study of Solubility for Imatinib Mesylate in Nine Monosolvents and Two Binary Solvent Mixtures from 278.15 to 318.15 K

Solubility of l-Phosphinothricin and Its Hydrochloride in Water + (Methanol and Ethanol) Binary Solvent Mixtures from 278.15 to 318.15 K

Solubility Determination and Thermodynamic Properties of Bezafibrate in Pure and Binary Mixed Solvents

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