Solubility of low density (β-)lipoproteins in the presence of dextran

Iverius, Per-Henrik

doi:10.1016/0009-8981(68)90158-7

Cited by 21 publications

(6 citation statements)

References 17 publications

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“…Furthermore Smith and Slater (75) found that the amounts of LDL recovered at autopsy in aortic intimas were positively and highly significantly correlated to the serum cholesterol levels some time before death. Also the glucoseaminoglucans of aortic wall interact with and bind LDL and VLDL (45). Considering these earlier studies it seems possible that our finding of increased frequency of ST depressions with increasingVLDLand LDL concentrations may be the result of an increased atherosclerosis due to raised LP concentrations in the coronary arteries.…”

Section: Combined Lps and S T Depressionmentioning

confidence: 50%

Studies in Asymptomatic Primary Hyperlipidaemia

Olsson¹,

Ekelund²,

Carlson³

1975

Journal of Internal Medicine

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Abstract. Among approximately 20000 apparently healthy subjects whose serum cholesterol and triglyceride (TG) values were screened at a health examination, those with the most pronounced hyperlipidaemia have been selected for further studies. Thus 188 males and 126 females, aged 30–65 years, with asymptomatic primary hyperlipoproteinaemia (HLP) and 59 male and 69 female controls with non‐elevated serum lipids were studied with regard to frequency of ST segment depressions during exercise to near maximal heart rate. Furthermore, the concentrations of cholesterol and TG were determined in the lipoprotein (LP) classes very low (VLDL), low (LDL) and high (HDL) density LP, separated by preparative ultracentrifugation. From the LP analysis each subject's HLP was classified according to the typing system of HLP recommended by the WHO. The frequency of ST depressions (Minnesota code 4.1–4.3 as well as 4.1–4.4) increased with age, was higher in females than in males and was increased in all types of HLP in males. The percentage frequencies of ST depressions 4.1–4.4 in the various types of HLP were (male/female, p against controls): controls 16/36, type IIA 50 (p<0.01)/56, type IIB 64 (p<0.01)/75 (p<0.05), type III 67 (p<0.01)/33 and type IV HLP 40 (p<0.01)/53. There was no significant difference in the frequencies of ST depressions in subjects with “high” and “low” BP (hypertensives were excluded from the study) or in subjects with “high” and “low” k‐value for the i.v. glucose tolerance. Non‐smokers had a tendency to higher frequencies of ST depressions than smokers. The association between different LPs and other “risk factors” and the occurrence of ST depressions in HLP were studied further with multiple regression analysis. Invariably age was the best predictor of ST depressions. The LP fraction giving the highest correlation coefficient was LDL cholesterol in both sexes. VLDL TG and LDL TG were also positively and significantly associated with ST depressions. HDL cholesterol was negatively but insignificantly correlated to ST depressions. When age and LDL cholesterol had been entered into the multiple regression, the only factor giving further significance was VLDL TG in males. Probability tables for the occurrence of ST depressions considering age and different levels of LDL cholesterol and VLDL TG were given. The importance of simultaneous consideration of both VLDL TG and LDL cholesterol in ST segment depression was evident from the tables. Of other “risk factors” (BP, glucose tolerance, smoking, ESR) entered into the regression together with only age or with age and the LPs, only ESR contributed with borderline significance to ST depressions.

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Section: Combined Lps and S T Depressionmentioning

confidence: 50%

Studies in Asymptomatic Primary Hyperlipidaemia

Olsson¹,

Ekelund²,

Carlson³

1975

Journal of Internal Medicine

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“…Infusions of dextran limit the extracellular plasma compartment and reduce the available space for protein solution. If the resulting concentration of protein exceeds the value of solubility, the protein is precipitated by steric exclusion [14,15,19]. These concentrations are not reached in vivo.…”

Section: Discussionmentioning

confidence: 99%

Lowering of plasma cholesterol in herbivores and omnivores by low molecular weight dextran

Adam

Krejci

1989

Res. Exp. Med.

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Two rabbits and two home pigs were infused in a cross-over design with equal volumes, adapted to the plasma volumes of the animals, of dextran-40 and saline. The infusions resulted in a reduction of plasma cholesterol and control parameters, such as plasma protein, hemoglobin, and hematocrit. The reduction of hemoglobin and hematocrit was related to plasma expansion with both infusion regimens. With dextran-40 infusions the reduction of plasma protein was greater than hemodilution in both species (-18% in rabbits and -20% in home pigs), because of steric exclusion of the protein. Lowering of plasma cholesterol in rabbits was comparable to the reduction in plasma protein, whereas in home pigs the reduction of plasma cholesterol (-25%) surpassed that of plasma protein. Reports in the literature have shown that dextran infusions increase cholesterol concentration in liver cells, leading to a reduction of intestinal cholesterol resorption in omnivores. This dextran effect is supposed to be responsible for the observed additional reduction of plasma cholesterol levels in omnivores.

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“…These exudates are reduced by long-term treatment with clofibrate; the drug, however, does not have any demonstrable effect on vascular changes in diabetic retinopathy (3, 4). It has been shown repeatedly that macromolecules like high molecular weight dextrans and hyaluronic acid, which form the extracellular matrix, decrease the solubility of other macromolecules by steric exclusion (6,7,9,10). In diabetic retinopathy the damaged vessels allow exudation of plasma components under pressure into the extravascular space.…”

Section: Discussionmentioning

confidence: 99%

Long‐term Effect of Clofibrate on Albumin Turnover and Distribution in Man

Briem

Helgason

Gudmundsson

1978

Journal of Internal Medicine

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ABSTRACT. The long‐term effect of clofibrate (at least 6 months' treatment) on albumin metabolism was investigated in 7 subjects and the results were compared with those from 15 control subjects. Human albumin labelled with 131I was used as a tracer. A significant difference between the groups was found in the following parameters: The clofibrate‐treated group had a prolonged rapid component (t1 1/2) of the disappearance curve (p <0.05), relatively increased albumin in the extravascular space (i.e. decreased distribution ratio, (p <0.01) and increased extravascular albumin space when corrected for body size by calculating it as per cent of the extravascular bromide space (p <0.01). There was no significant difference between the groups in albumin synthesis, fractional catabolic rate or the slow component (t2 1/2) of the disappearance curve. The results suggest that long‐term treatment with clofibrate causes changes in the intercellular matrix.

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Solubility of low density (β-)lipoproteins in the presence of dextran

Cited by 21 publications

References 17 publications

Studies in Asymptomatic Primary Hyperlipidaemia

Studies in Asymptomatic Primary Hyperlipidaemia

Lowering of plasma cholesterol in herbivores and omnivores by low molecular weight dextran

Long‐term Effect of Clofibrate on Albumin Turnover and Distribution in Man

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