Solubility of Clopidogrel Hydrogen Sulfate (Form II) in Ethanol + Cyclohexane Mixtures at (283.35 to 333.75) K

Abstract

As the solvent system ethanol + cyclohexane is selected for the purification of clopidogrel hydrogen sulfate (Form II) [CHS(II)], the solubilities of CHS(II) in the binary solvent mixtures were measured at the temperatures ranging from (283.35 to 333.75) K. The solubility increased with both the rising temperature and mole fraction of ethanol in the binary solvent. The experimental data were well-fitted by the Jouyban−Acree model, and the thermodynamic parameters were calculated correspondingly. The result demonstrated that the dissolution process of CHS(II) in the ethanol + cyclohexane mixture was endothermic and entropy-driven.

Solution thermodynamics of creatine monohydrate in binary (water + ethanol) solvent systems at T = (278.15 to 328.15) K

“…The apparatus was same as those described in the literature [15,16]. The dissolution of the solute was implemented in a jacketed crystallizer, and a cold water condenser was equipped to stop the solvent evaporating.…”

Solubility of Diflufenican in Pure and Binary Solvent Systems

“…The solubility of diflufenican in pure solvents (methanol, ethanol, isopropyl alcohol, ethyl acetate, acetone, toluene, cyclohexane, and benzene) and binary solvents (acetone + water, acetone + ethanol) was determined by a dynamic method using the laser detecting technique, whose accuracy has been confirmed in previous literature. − The experimental device, same as that in previous literature, is shown in Figure . The measurement was carried out in a jacketed glass crystallizer, whose interlayer was connected with a water bath (SHP DC-2015, China) to control the temperature.…”

Solubility of 1,3,5-Benzenetricarboxylic Acid in Different Solvents

“…The solubilities of 1,3,5-benzenetricarboxylic acid in different solvents were measured by a synthetic method with a laser monitoring observation technique. The procedure and apparatus of the solubility measurement is the same as those in the literature. , …”

“…The procedure and apparatus of the solubility measurement is the same as those in the literature. 5,6 The laser monitoring system was made up of a laser generator, a photoelectric transformer, and a light intensity display. The laser beam penetrated the solution to detect the solid in it.…”