Solubility of Clonazepam and Diazepam in Polyethylene Glycol 200, Propylene Glycol, <i>N</i>-Methyl Pyrrolidone, Ethanol, and Water at (298.2 to 318.2) K and in Binary and Ternary Mixtures of Polyethylene Glycol 200, Propylene Glycol, and Water at 298.2 K

Soltanpour, Shahla; Bastami, Zahra; Sadeghilar, Shayan; Kouhestani, Morteza; Pouya, Farid; Jouyban, Abolghasem

doi:10.1021/je3009842

Cited by 9 publications

(6 citation statements)

References 14 publications

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“…In the pharmaceutical industry, propylene glycol is used as a solvent to increase the apparent solubility and the permeation of drugs through lipid membranes [16][17][18][19][20] and as such is used commonly as a co-solvent in oral, intravenous [21][22][23] and topical preparations. 18,24 Interestingly, encapsulating drugs into PG containing liposomes results in a substantial increase in drug-solubility which increases with PG concentration.…”

Section: Introductionmentioning

confidence: 99%

On the structure of an aqueous propylene glycol solution

Rhys

Gillams

Collins

et al. 2016

The Journal of Chemical Physics

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Using a combination of neutron diffraction and empirical potential structure refinement computational modelling, the interactions in a 30 mol. % aqueous solution of propylene glycol (PG), which govern both the hydration and association of this molecule in solution, have been assessed. From this work it appears that PG is readily hydrated, where the most prevalent hydration interactions were found to be through both the PG hydroxyl groups but also alkyl groups typically considered hydrophobic. Hydration interactions of PG dominate the solution over PG self-self interactions and there is no evidence of more extensive association. This hydration behavior for PG in solutions suggests that the preference of PG to be hydrated rather than to be self-associated may translate into a preference for PG to bind to lipids rather than itself, providing a potential explanation for how PG is able to enhance the apparent solubility of drug molecules in vivo.

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Section: Introductionmentioning

confidence: 99%

On the structure of an aqueous propylene glycol solution

Rhys

Gillams

Collins

et al. 2016

The Journal of Chemical Physics

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“…Temperature plays a pivotal role in shaping the solubility of substances, but the CNIBS/R-K model lacks precision in illustrating their interdependence. Employing the Jouyban–Acree–van’t Hoff model provides a more accurate portrayal of how temperature and solvent ratios impact solubility. − The model is characterized by – ln nobreak0em0.25em⁡ x = x A ln nobreak0em0.25em⁡ X A + x B ln nobreak0em0.25em⁡ X B + x A x B ∑ i = 0 N J i false( x A .25em − .25em x B false) i T …”

Section: Thermodynamic Modelsmentioning

confidence: 99%

“…The meaning of the remaining characters is the same as that in eq . The reduced function eq was used instead of eq : , ln nobreak0em0.25em⁡ x = x A ( A 1 + B 1 T ) + x B ( A 2 + B 2 T ) + x A x B ∑ i = 0 N J i false( x A .25em − .25em x B false) i T …”

Section: Thermodynamic Modelsmentioning

confidence: 99%

Solubility Determination and Thermodynamic Model Analysis of Esculetin in Different Solvents from 273.15 to 318.15 K

Yang,

Yan,

Huang

et al. 2024

J. Chem. Eng. Data

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Esculetin is derived from the leaves of lemons of Rutaceae and the bark of bittersweet ash, belladonna, mandala, and Rehmannia plants. In this research, the solubility of esculetin in ten solvents such as ethyl acetate, isobutyl alcohol, water, methanol, acetonitrile, n-propyl alcohol, isopropyl alcohol, n-butanol, ethanol, and acetone was determined by utilizing static equilibrium-high performance liquid chromatography (HPLC) under standard atmospheric pressure conditions and temperatures in the range of 273.15 to 318.15 K. Among the above ten pure solvents, water displayed the least solubility, while methanol exhibited the highest solubility. At the same temperature (T = 273.15 ∼ 318.15 K), the solubility of esculetin increased with the increase of the molar ratio of soluble solvents. Similarly, when the temperature increases (T = 273.15 ∼ 318.15 K), the solubility of the three binary solvents increases under the condition of a constant molar ratio. The above results suggest that the main factor affecting the solubility of esculetin in the solvent may be the polarization/bipolarity of the solvent. The experimental data was fitted by five thermodynamic models (the Buchowski−Ksiazaczak λh model, the Modified Apelblat model, the Jouyban−Acree model, the SUN model, and the CNIBS/R-K model), and the relative average deviation and root-mean-square deviation of the data were calculated, which proved that the correlation of the solubility data and the five models was relatively good. XRD and DSC were used to detect the crystal form and stability of esculetin during the experiment.

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“…A purely phenomenological approach has been applied by Zhao et al by studying excess properties for PEG 200/DMSO solutions and correlated them to their viscosities [19]. Soltanpour et al have applied this phenomenological approach to study the dissolution of drugs in pyrrolidone, ethanol, and water [20,21]. Another important feature of these macromolecules is that they may form aggregates, depending on solvent and experimental conditions [22,23].…”

Section: Introductionmentioning

confidence: 99%

Coil Interpenetration, Segment Aggregation and Adsorption of PEG at Water/Air Interface

Rego

Melo

Neto

et al. 2017

J Surfact & Detergents

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Poly(ethylene glycol) (PEG), both as an oligomer and as a high molecular weight polymer, has been used as a surfactant active component in many applications, in its pure and unmodified structure, or as a block segment within more complex structures. Apart from assuming helical or coil conformations it may also undergo aggregation, depending on the solvent. In this work, we characterized the aggregation of PEG in water using surface tensiometry and turbidimetry. Aggregation was characterized by a non‐persistent surface tension plateau at higher PEG contents and confirmed by turbidimetry, which was correlated to the derivative of osmotic pressure in relation to concentration. One can divide a surface tension‐concentration curve into two regions, delimited by a characteristic concentration: one following a Langmuir adsorption isotherm (starting from a plateau equal to pure water surface tension) ending in a second plateau, and a second one (beginning at this plateau) following a Freundlich isotherm. The calculated surface excess for PEG segment adsorption was consistent with segment aggregation, indicating more two characteristic concentrations correlated to this occurrence. A total of three characteristic mer concentrations were found (6.2 × 10−7, 6 × 10−6, and 2 × 10−4mol L−1) and related to PEG segment aggregation states.

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Solubility of Clonazepam and Diazepam in Polyethylene Glycol 200, Propylene Glycol, N-Methyl Pyrrolidone, Ethanol, and Water at (298.2 to 318.2) K and in Binary and Ternary Mixtures of Polyethylene Glycol 200, Propylene Glycol, and Water at 298.2 K

Cited by 9 publications

References 14 publications

On the structure of an aqueous propylene glycol solution

On the structure of an aqueous propylene glycol solution

Solubility Determination and Thermodynamic Model Analysis of Esculetin in Different Solvents from 273.15 to 318.15 K

Coil Interpenetration, Segment Aggregation and Adsorption of PEG at Water/Air Interface

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