Solubility of Calcium Phosphate Glasses and Glass Ceramic Materials in Water and Physiological Media

Mikhailenko, N. Yu.; Stroganova, E. E.; Бучилин, Н. В.

doi:10.1007/s10717-013-9531-8

Cited by 7 publications

(8 citation statements)

References 8 publications

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“…The statistical outputs are shown in the form of a mean with Standard Error (±SE). A one-way analysis of variance (Mikhailenko et al, 2013) with Tukey's post hoc test was performed to analyse the significant differences and the significance levels were set at a pvalue of less than 0.05.…”

Section: Discussionmentioning

confidence: 99%

Influence of Degrading Calcium Phosphate on the Remodelling and Mineralisation of Avascular Osseous Tissue in a Rat Calvaria Model

Fernández¹,

Llano²,

Li³

et al. 2015

American Journal of Biochemistry and Biotechnology

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Artificial bone graftingis the subject of intensive investigation for craniofacial reconstruction. Among the syntheticcandi date materials, those incorporating Calcium Phosphates (CaP) have gained popularity, due to their osteoinductive properties. Despite many quantitative studies on the degradation rates of CaP biomaterials in vitro, there is lack of quantitative studies in relation to bone remodelling kinetics in vivo. In this investigation, we tested implants of degradable CaP/chitosan-based biomaterial in a rat calvaria model of critical-sized defects. We observed remarkable acceleration of bone growth in the initial stages (~0.8 g/day), which was markedly higher than normal bone growth rates (~0.1 g/day) in implant-free controls. The implanted CaP-based biomaterial significantly enhanced bone formation, with woven bone seen as early as 20 days and lamellar bone at 40 and 60 days post-implantation. However the mineralisation of cortical bone was delayed, due to the overly rapid degradation of the biomaterial: This therapeutically important issue has never been identified before to our best knowledge. A theoretical analysis revealed that during degradation CaP can be rapidly released from the new bone matrix. Hence, while the degradable CaP biomaterial was found to be highly osteoconductive in vivo, future modifications would seek to optimize degradation efficiency for more sustained release of mineral ions, to enhance bone mineralisation at later stages of the healing process after implantation.

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Section: Discussionmentioning

confidence: 99%

Influence of Degrading Calcium Phosphate on the Remodelling and Mineralisation of Avascular Osseous Tissue in a Rat Calvaria Model

Fernández¹,

Llano²,

Li³

et al. 2015

American Journal of Biochemistry and Biotechnology

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“…The CCF for each phantom material can then be measured by computing the ratio of the slope for bone mineral (presumed to be HAp) to that of the phantom material. 16 For the calcium phosphate glass systems, the phantom glass compositions were determined compositional data provided by Lee et al, 17 Mikhailenko et al, 18 and Kiseleva et al 19 All of these works did not assess glass mass density, and as such, the mass density of each glass phantom was calculated estimated using the following approximation:…”

Section: Methodsmentioning

confidence: 99%

“…Lee et al 17 already reported the weight fractions for each element of their CaO-P 2 O 5 -TiO 2 glass system. Mikhailenko et al 18 reported the molar ratio CaO/P 2 O 5 = 1.1 and molar contents of Al 2 O 3 (7.5%) and SiO 2 (20%) for each of their CaO-P 2 O 5 -Al 2 O 3 and CaO-P 2 O 5 -SiO 2 glass systems, and so the weight fractions for each element were determined using the associated molar masses. Kiseleva et al 19 reported just the molar contents of CaO (16%) and CuO (16%) for their CaO-P 2 O 5 -CuO glass system, and again the weight fractions for each element were determined using the associated molar masses.…”

Section: Methodsmentioning

confidence: 99%

Evaluating calcium phosphate glass phantoms for the calibration of in vivo X-ray fluorescence spectrometry-based methods of bone strontium quantification

Micsa,

Da Silva

2023

J. Anal. At. Spectrom.

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“…The solubility behavior of the glasses under study however shows that water can diffuse into the glass structure causing some cations to release into the surrounding medium, resulting in increased % weight loss and consequently higher pH and ion release profiles. Previous studies [329,330] have shown that solubility of a glass system strongly depends on the glass composition. It can be generalized that the addition of network modifiers disrupts bonds within the glass network resulting in increased number of NBOs and subsequently increased hydration/solubility when aged in a medium such as water or SBF.…”

Section: Glass Solubility Propertiesmentioning

confidence: 99%

Design & development of a novel glass polyalkenoate cement for sternal fixation and repair, in the event of median sternotomy surgery

Alhalawani¹

2021

Preprint

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Median sternotomy surgery is the gold standard for cardiac/thoracic procedures such as open-heart surgery. With over one million median sternotomy surgeries performed worldwide every year, sternal wound complications pose a serious risk to the health of affected patients. Various techniques have been used for sternal fixation including wiring, plate-screw systems and cementing. The ideal sternal closure device is the one which has mechanical properties suited to the local environment, biocompatibility, radio-opacity, cost-effectiveness and ease of removal when necessary. None of the techniques that have been utilized for sternal fixation to date address all of these requirements. Glass polyalkenoate cements (GPCs) have a long history of use in restorative and orthodontic dentistry and ear, nose and throat (ENT) surgery but have yet to be indicated for musculoskeletal applications. This dissertation relates to the development of new GPC-based adhesives for use in sternal closure. A series of novel glasses based on the system 48SiO2-(36-X) ZnO-6CaO-8SrO-2P2O5-XTa2O5 with X varying from 0.0 to 8.0 mole percentage were fabricated and characterized. The structural features as a function of Ta2O5 content were investigated by network connectivity (NC) calculations, x-ray diffraction (XRD), particle size analysis (PSA), scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS), x-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR) and magic angle spinning-nuclear magnetic resonance (MAS-NMR). The thermal properties of the glasses were obtained by performing simultaneous thermal analysis (STA). The effect of glass structure on pH and solubility was also evaluated. The formulated glasses were used to prepare GPC adhesive materials and tested for their suitability for sternal fixation. The data collected has confirmed that substituting up to 0.5 mole percentage of ZnO with Ta2O5 in the glass system under study resulted in the formation of adhesives that are deemed suitable for sternal fixation. The formulated cements, based on the use of glasses containing no greater than 0.5 mole percentage of Ta2O5 have rheology, strength, radiopacity, antibacterial and in-vitro behavior suitable for sternal fixation. To the best knowledge of the candidate, this dissertation is the first to report the use of tantalum-containing GPC-based adhesives for sternal closure. Based on the obtained results, the formulated adhesives can be used in conjunction with sternal cable ties (current standard method) to offer optimal fixation for patients and reduce post-operative complications such as bacterial infection and pain from micro-motion.

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Solubility of Calcium Phosphate Glasses and Glass Ceramic Materials in Water and Physiological Media

Cited by 7 publications

References 8 publications

Influence of Degrading Calcium Phosphate on the Remodelling and Mineralisation of Avascular Osseous Tissue in a Rat Calvaria Model

Influence of Degrading Calcium Phosphate on the Remodelling and Mineralisation of Avascular Osseous Tissue in a Rat Calvaria Model

Evaluating calcium phosphate glass phantoms for the calibration of in vivo X-ray fluorescence spectrometry-based methods of bone strontium quantification

Design & development of a novel glass polyalkenoate cement for sternal fixation and repair, in the event of median sternotomy surgery

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