Solubility of aceclofenac in polyamidoamine dendrimer solutions

Patel, Jay; Garala, Kevin; Basu, Biswajit; Raval, Mihir; Dharamsi, Abhay

doi:10.4103/2230-973x.85962

Cited by 29 publications

(17 citation statements)

References 28 publications

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“…This suggested that lauroyl chain should be functionalized to lower PAMAM generation (G0) rather than high PAMAM generations for optimal drug delivery and solubility of NAP. Similar observations were previously reported by Patel et al and Choudhary et al for solubility enhancement studies of various PAMAM dendrimer generations to aceclofenac ( 17 ), another poorly soluble NSAID drug [ 55 , 56 ].…”

Section: Experimental Insights On Pamam-drug Interactions For Enhasupporting

confidence: 88%

Polyamidoamine Dendrimers for Enhanced Solubility of Small Molecules and Other Desirable Properties for Site Specific Delivery: Insights from Experimental and Computational Studies

et al. 2018

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Clinical applications of many small molecules are limited due to poor solubility and lack of controlled release besides lack of other desirable properties. Experimental and computational studies have reported on the therapeutic potential of polyamidoamine (PAMAM) dendrimers as solubility enhancers in pre-clinical and clinical settings. Besides formulation strategies, factors such as pH, PAMAM dendrimer generation, PAMAM dendrimer concentration, nature of the PAMAM core, special ligand and surface modifications of PAMAM dendrimer have an influence on drug solubility and other recommendable pharmacological properties. This review, therefore, compiles the recently reported applications of PAMAM dendrimers in pre-clinical and clinical uses as enhancers of solubility and other desirable properties such as sustained and controlled release, bioavailability, bio-distribution, toxicity reduction or enhancement, and targeted delivery of small molecules with emphasis on cancer treatment.

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Section: Experimental Insights On Pamam-drug Interactions For Enhasupporting

confidence: 88%

Polyamidoamine Dendrimers for Enhanced Solubility of Small Molecules and Other Desirable Properties for Site Specific Delivery: Insights from Experimental and Computational Studies

et al. 2018

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“…It has been proved that dendrimers may have the potential to improve the solubility of low aqueous soluble drugs and as a carrier for bioactive materials. [ 3 ] Among them, the polyamidoamine (PAMAM) dendrimer is one of the well-known dendrimers and has been proven as a carrier to improve water solubility and the rate of dissolution of drugs such as ketoprofen,[ 4 ] ibuprofen,[ 5 ] aceclofenac,[ 6 ] and riboflavin. [ 7 ]…”

Section: Introductionmentioning

confidence: 99%

Prolonged drug delivery system of an antifungal drug by association with polyamidoamine dendrimers

Jose¹,

Charyulu²

2016

Int J Pharma Investig

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Introduction:The potent antifungal agent amphotericin B (AmB) is not freely soluble in water. The clinical use of AmB is limited by nephrotoxicity and poor water solubility. Polyamidoamine (PAMAM) dendrimer offers an identical carrier for drug binding that has the capacity to attach and discharge drugs in numerous ways.Materials and methods:In this research work, we explored the potential of PAMAM dendrimers to improve the solubility of AmB.Results and discussion:The experimental results indicated that the solubility of AmB was greatly enhanced in the presence of PAMAM dendrimer solutions. Results indicated that the solubility of AmB enhanced with increase in dendrimer generations as well as concentration. In vitro release studies of AmB in the presence of the third generation of PAMAM dendrimers was performed by the dialysis method. Our research work revealed that binding of drug into dendrimers led to sustained release of AmB in vitro.Conclusion:Based on the stability studies, it was concluded that the drug dendrimer complex should be stored in a dark place at a cool temperature.

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“…The effect of dendrimer hydrogen particle focus on the solvency improvement of aceclofenac can be a direct result of a power association among NH 2 groups of dendrimer and furthermore the COOH bunch of the medication. The aceclofenac dissolvability was observed to be correspondingly relative to the temperature of the dendrimer goals 35 .…”

Section: Fig 5: Factors Affecting Dendrimer-mediated Drug Solubilizamentioning

confidence: 98%

“…Aceclofenac is just about insoluble in water. Concentrates have reportable that the solvency of Aceclofenac has significantly expanded exploitation G0 PAMAM dendrimers 35 .…”

Section: Fig 5: Factors Affecting Dendrimer-mediated Drug Solubilizamentioning

confidence: 99%

Untitled

2020

IJPSR

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Sufficient fluid solvency has been one in everything about required properties while choosing drug particles and completely uncommon bio-actives for advancement. Here and there dissolvability of a medication decides its pharmaceutical and remedial execution. Most of these days organized medicine IOTAS miss the mark or are rejected for the length of the main times of drug disclosure and improvement on account of the truth of their obliged dissolvability. Test consistency, liquid dissolvability, and manufactured equality of the prescription are central for touching base at enough bioavailability and supportive outcome. Dendrimers, an alternate class of polymers, have the decent potential for medication solvency improvement, by temperance of their unmistakable properties. These hyper-stretched, mono-scattered particles have the particular capacity to tie the medication atoms on fringe still to typify these particles among the fiber structure. There are differed reportable investigations that have effectively utilized dendrimers to flavor up the solubilization of inadequately solvent prescription. These promising results have intrigued the analysts to vogue, orchestrate, and evaluate fluctuated fiber polymers for his or her utilization in medication conveyance and product improvement. This survey will talk about the perspectives and the job of dendrimers at interims the solvency improving the ineffectively solvent drug. This survey can feature the significant and important properties of dendrimers that contribute to medication solubilization. At last, hydrophobic medicine that is investigated for dendrimer helped solubilization, and subsequently, this advancing remaining of dendrimers are referenced here. INTRODUCTION: The significance of the new polymers utilized for the medication in Programming interface conveyance into the life structures, some way or another it's horribly hard to initiate all Programming interface of medication solubilized in our life systems that is the reason researchers have built up a fresh out of the box new class synthetic exacerbate that is comprehended as Dendrimers.

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Solubility of aceclofenac in polyamidoamine dendrimer solutions

Cited by 29 publications

References 28 publications

Polyamidoamine Dendrimers for Enhanced Solubility of Small Molecules and Other Desirable Properties for Site Specific Delivery: Insights from Experimental and Computational Studies

Polyamidoamine Dendrimers for Enhanced Solubility of Small Molecules and Other Desirable Properties for Site Specific Delivery: Insights from Experimental and Computational Studies

Prolonged drug delivery system of an antifungal drug by association with polyamidoamine dendrimers

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