Solubility Measurement and Correlation of Doxycycline Hyclate in 10 Pure Solvents and Mixtures Solvents at 278.15–323.15 K

Shen, Yanmin; Liu, Wenju; Sun, Caige; Shi, Paifeng

doi:10.1021/acs.jced.0c00097

Cited by 7 publications

(5 citation statements)

References 21 publications

(47 reference statements)

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“…The Apel-J-A model (eq ) is a three-dimensional (3D) model (composed of the M-Apel model and Jouyban–Acree model), which can describe the relationship among temperature, solvent composition, and solubility. − …”

Section: Solid–liquid Phase Equilibrium Modelsmentioning

confidence: 99%

Solubility Behavior of N-Carbobenzoxy-l-2-phenylglycine in 11 Pure and a Binary Ethanol + Water Solvent Systems at 283.15–323.15 K

Zhao

Qiu

et al. 2021

J. Chem. Eng. Data

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The mole fraction solubility data of N-carboxyphenoxy-L-2-phenylglycine in 11 neat solvents (methanol, water, isopropyl alcohol, ethanol, n-propyl alcohol, methyl acetate, ethyl acetate, acetone, dichloromethane, acetonitrile, and butanone) and a binary solvent mixture of ethanol + water were determined by the static gravimetric method at 283.15–323.15 K. From the solvent effect analysis, the solubility behavior was affected not only by polarity, but also by some other factors such as hydrogen bonding, cohesive energy density, and molecular structure. The solubility data of N-carboxyphenoxy-L-2-phenylglycine were correlated by using the two-dimensional modified Apelblat model and three-dimensional Apelblat–Jouyban–Acree model. The maximum values of root-mean-square deviation and relative average deviation were 100.98 × 10–4 and 20.53%, respectively. The solubility calculated by the two models agreed well with the experimental values.

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Section: Solid–liquid Phase Equilibrium Modelsmentioning

confidence: 99%

Solubility Behavior of N-Carbobenzoxy-l-2-phenylglycine in 11 Pure and a Binary Ethanol + Water Solvent Systems at 283.15–323.15 K

Zhao

Qiu

et al. 2021

J. Chem. Eng. Data

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“…The solubility of GA in DMF was higher than in alcohols or ester solvents because of the functional group −NH 2 in GA and DMF. In a word, the solubility of GA could not be elaborated by HSP and solvent polarity well because solubility might be affected by multiple factors, such as solute–solvent molecular interaction, solvent structure, solvent polarity, hydrogen bonding, and HSP. ,,− …”

Section: Resultsmentioning

confidence: 99%

“…Solid–liquid solubility data of GA in 12 pure organic solvents were determined using the static equilibrium method by previous work. − First, excess GA and 40 mL of solvent were added in a double-jacketed glass container. The glass container equipped was placed in a thermostatic water bath (Shanghai Bilon Instrument Co., Ltd., China) equipped with an electromagnetic stirrer.…”

Section: Methodsmentioning

confidence: 99%

Equilibrium Solubility of 18β-Glycyrrhetinic Acid in 12 Pure Solvents: Determination, Correlation, and Hansen Solubility Parameter

Shen

Zhao

et al. 2022

J. Chem. Eng. Data

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In this study, the solubility data of 18β-glycyrrhetinic acid (GA) in 12 neat solvents were determined by the static equilibrium method at a temperature range of 278.15–323.15 K under a pressure of 0.1 MPa. These selected solvents were methanol, ethanol, n-propanol, isopropanol, methyl acetate, propyl acetate, butyl acetate, isobutyl acetate, acetone, 1,4-dioxane, N,N-dimethylformamide (DMF), and tetrahydrofuran (THF). The experimental results showed that the solubility of GA was positively correlated with temperature and was correlated using thermodynamic models. Activity coefficient models such as the NRTL model, Wilson model, Margules model, and van Laar model were applied to fit the experimental solubility of GA. A good relevance can be obtained for data fitting using these models, and the best fitting effect was achieved with the Wilson equation from ARD and R 2. The Hansen solubility parameter was applied to explain the GA solubility phenomenon in pure solvents. These study results contribute to crystallization operation of GA for purification and separation.

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“…This group of drugs is found within the sewer and most aquatic environments and different soil levels( Czech et al, 2021 ). The water solubility of Naproxen and doxycycline is 15900 and 50000 μg/L, respectively ( Mora and Mart í nez, 2007 ; Isidori et al, 2005 ; Bogardus and Blackwood, 1979 ; Shen et al, 2020 ). However, The WHO has confirmed the presence of the remaining 15–25 μg/L high-dose drugs in drinking water ( Organization, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Fabrication of HKUST-1/ZnO/SA nanocomposite for Doxycycline and Naproxen adsorption from contaminated water

Lü

Haddao

Emami

et al. 2022

Sustainable Chemistry and Pharmacy

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Solubility Measurement and Correlation of Doxycycline Hyclate in 10 Pure Solvents and Mixtures Solvents at 278.15–323.15 K

Cited by 7 publications

References 21 publications

Solubility Behavior of N-Carbobenzoxy-l-2-phenylglycine in 11 Pure and a Binary Ethanol + Water Solvent Systems at 283.15–323.15 K

Solubility Behavior of N-Carbobenzoxy-l-2-phenylglycine in 11 Pure and a Binary Ethanol + Water Solvent Systems at 283.15–323.15 K

Equilibrium Solubility of 18β-Glycyrrhetinic Acid in 12 Pure Solvents: Determination, Correlation, and Hansen Solubility Parameter

Fabrication of HKUST-1/ZnO/SA nanocomposite for Doxycycline and Naproxen adsorption from contaminated water

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