Solubility Measurement and Correlation of Ceftiofur Sodium Trihydrate in Four Binary Solvent Mixtures

Liu, Xinyu; Li, Wanya; He, Yang; Du, Shichao; Yin, Hongxi; Gong, Junbo; Wu, Songgu

doi:10.1021/acs.jced.9b01088

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…The modified Apelblat model was purposed by Apelblat et al, which can be used to correlate the solubility data in both pure solvent and binary solvent. − The model can be expressed as follows. where x refers to the mole fraction solubility of the solute; T is temperature of the solvent system; and A , B , and C are the model parameters.…”

Section: Thermodynamic Modelsmentioning

confidence: 99%

Solubility Measurement of Crystal Form II and Form V Ticagrelor in Several Pure Organic Solvents

Shunping

Zhang

et al. 2021

J. Chem. Eng. Data

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Ticagrelor (TCG) is a P2Y12 platelet inhibitor and has several crystal forms including Form II and Form V. In this work, it has been confirmed that Form II TCG would gradually transform to Form V in selected solvents. According to the crystal form stability, a dynamic method was adopted to measure the solubility of Form II TCG in six pure solvents (n-propanol, isopropanol, n-butanol, 2-butanol, ethyl acetate, and isopropyl acetate). The solubility of Form V TCG in 12 pure solvents (methanol, ethanol, n-propanol, isopropanol, n-butanol, 2-butanol, methyl acetate, ethyl acetate, isopropyl acetate, acetone, 2-butanone, and cyclohexanone) was measured by a static method. The solubility measurement temperature range was from 273.15 to 313.15 K. The experimental solubility data were correlated by the modified Apelblat model and the λh model. It was shown that the calculated solubility was consistent with the experimental data.

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Section: Thermodynamic Modelsmentioning

confidence: 99%

Solubility Measurement of Crystal Form II and Form V Ticagrelor in Several Pure Organic Solvents

Shunping

Zhang

et al. 2021

J. Chem. Eng. Data

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“…The equation is based on the assumption that the enthalpy of the solution varies linearly with the temperature and is deduced through the integration of the Clausius−Clapeyron equation. 12 The common form of the modified Apelblat equation is given in eq 3…”

Section: Theoretical Basismentioning

confidence: 99%

“…The modified Apelblat equation , is another simple semiempirical equation widely used in solubility correlation. The equation is based on the assumption that the enthalpy of the solution varies linearly with the temperature and is deduced through the integration of the Clausius–Clapeyron equation . The common form of the modified Apelblat equation is given in eq where a , b , and c are the three parameters of the equation.…”

Section: Theoretical Basismentioning

confidence: 99%

Measurement and Correlation of the Solubility of 4,4′-Oxydianiline in Four Binary Solvent Mixtures from T = 293.15 to 333.15 K

Wang

Yin

et al. 2021

J. Chem. Eng. Data

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Metrics & More Article Recommendations * sı Supporting Information ABSTRACT: 4,4′-Oxydianiline (ODA) is a versatile fine chemical intermediate with huge market demand. The purification of ODA is accomplished by crystallization with some high-boiling-point liquids as solvents, but the product yields are usually low in these pure solvents. Using a mixture of a poor solvent such as ethanol and a high-boiling-point liquid as the solvent can improve the yield of ODA, and the design of the new crystallization process requires the solubility properties of ODA in the new solvent system. However, these data have never been reported. In this work, the solubility of 4,4′-oxidianiline in dimethyl sulfoxide + ethanol, N,Ndimethylacetamide + ethanol, N,N-dimethylformamide + ethanol, and ethylene glycol monomethyl ether + ethanol binary solvent mixtures from 293.15 to 333.15 K was measured by the gravimetric method under atmospheric pressure. The solubility of ODA increases with the increase in temperature and decreases with the increase in the mass fraction of ethanol. The experimental solubility data of ODA were correlated by the Van't Hoff equation, the modified Apelblat equation, the CNIBS/ R−K model, the Van't Hoff−Jouyban−Acree model, and the Apelblat−Jouyban−Acree model. The calculated values are in good agreement with the measured solubility data for all five models, among which the modified Apelblat equation provides the best correlation.

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Measurement and correlation of 4,4′-dihydroxydiphenylsulfone solubility in ten neat organic solvents at temperatures from 278.15 to 313.15 K

Mao

Song²,

Wang³

et al. 2022

The Journal of Chemical Thermodynamics

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Solubility Measurement and Correlation of Ceftiofur Sodium Trihydrate in Four Binary Solvent Mixtures

Cited by 4 publications

References 22 publications

Solubility Measurement of Crystal Form II and Form V Ticagrelor in Several Pure Organic Solvents

Solubility Measurement of Crystal Form II and Form V Ticagrelor in Several Pure Organic Solvents

Measurement and Correlation of the Solubility of 4,4′-Oxydianiline in Four Binary Solvent Mixtures from T = 293.15 to 333.15 K

Measurement and correlation of 4,4′-dihydroxydiphenylsulfone solubility in ten neat organic solvents at temperatures from 278.15 to 313.15 K

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