Solubility Measurement and Correlation of Fosfomycin Sodium in Six Organic Solvents and Different Binary Solvents at Temperatures between 283.15 and 323.15 K

Abstract

The solubility data of fosfomycin sodium (FOM-Na) in six pure solvents (methanol, ethanol, propanol, cyclohexane, acetone, N,N-dimethylformamide) and two binary solvents (methanol + ethanol, methanol + acetone) at temperatures ranging from 283.15 to 323.15 K were measured by a laser monitoring dynamic method at atmospheric pressure. It turned out that the solubility data decreased with increasing temperature, and also varies with the composition of the solvents. Moreover, the experimental data in pure solvents have been correlated with two thermodynamic models (i.e., modified Apelblat and van’t Hoff), and the data in binary solvents have been correlated with CNIBS/R-K equation and two modified versions of Jouyban–Acree models (Van’t-JA equation and Apel-JA equation), respectively. All the results showed a good agreement with the experimental data. Intermolecular interaction force and dielectric constants are introduced to explain the relationship between solubility and temperature. In addition, the analysis of the solubilities implies that higher temperature may destroy the forces between the solvent and solute molecules, leading to lower solubility. And this can give a guide to the design and optimization of the crystallization process of FOM-Na in the industry.

Solubility and Data Correlation of Isoniazid in Different Pure and Binary Mixed Solvent Systems from 283.15 K to 323.15 K

“…where A 0 −A 8 are adjustable parameters and obtained by leastsquares analysis. 34,35 The values of the above model parameters were optimized by minimizing the following objective function with experimental solubility data:…”

Measurement and Correlation of Solubility of Calcium Formate (Form α) in Different Binary Solvent Mixtures at Temperatures from 283.15 to 323.15 K

“…The mole fraction solubility ( x A ) of calcium formate (form α) in different binary solvent mixtures was calculated by eq , and the initial mole fraction ( x B ) of the organic solvent (methanol, ethanol, n -propanol, and acetone) of the binary solvent mixtures can be calculated by eq as follows where m 1 , m 2 , and m 3 denote the masses of calcium formate, organic solvents (methanol, ethanol, n -propanol, and acetone), and water, respectively. M 1 , M 2 , and M 3 represent the molecular weights of calcium formate, organic solvents (methanol, ethanol, n -propanol, and acetone), and water, respectively.…”

Solubility Determination of c-Met Inhibitor in Solvent Mixtures and Mathematical Modeling to Develop Nanosuspension Formulation

“…However, previous study already reported that the drug was weakly basic compound with pKa and log P of 7.49 and 2.46, respectively [ 1 ]. Hence, in this study, the solubility of the model drug in methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, acetonitrile, acetone, ethyl acetate, Transcutol ® HP (THP), water, and in Transcutol ® HP–water mixture (TWM) was determined at temperatures ranging from 298.15 K to 318.15 K under atmospheric pressure using the static equilibrium method [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. The modified Apelblat model (AM), van’t Hoff model (VHM), and Buchowski–Ksiazaczak λh model (BKM) were used to correlate the experimental solubility in selected organic solvents [ 14 , 15 , 16 ].…”