“…There are various well known techniques are used for enhancement of solubility of poorly soluble drugs which include physical and chemical modifications of drug and other methods like Solid dispersions (Alam et al, 2012;Leuner and Dressman, 2000;Murtaza et al, 2014), co-crystallization (Kim and Park, 2004;Miroshnyk et al, 2009;Shan and Zaworotko, 2008), particle size reduction like micronization and nanosuspension (Charoen chaitrakool et al, 2000;Chen et al, 2011;Liversidge and Cundy, 1995), cryogenic techniques (Charoenchaitrakool et al, 2000), complexation (Brewster and Loftsson, 2007;Loftsson and Brewster, 1996), salt formation (Blagden et al, 2007;Serajuddin, 2007), use of adjuvants like surfactants, solubilizers, co-solvents, and novel lipidic excipients (Blagden et al, 2007;Savjani et al, 2012). Of all, one of the contemporary approaches is Lipid based drug delivery systems (LBDDS) like self-microemulsifying DDS (SMEDDS) which usually present the drug to the stomach in a solubilized state, unlike tablets (Constantinides, 1995;Gao and Morozowich, 2006;Kommuru et al, 2001;Pouton and Porter, 2008).…”