Solubility enhancement of nimodipine through preparation of Soluplus® dispersions
Abstract:The present work aims to enhance the water solubility of nimodipine, a hydrophobic drug, using a solid dispersion (SD) technique. Soluplus ® as a novel hydrophilic polymeric carrier was used. Nimodipine-Soluplus ® SDs (1:10) were prepared by impregnation technique using supercritical fluid technology (SCF) and compared with the ones which were prepared by conventional hot-melt (HM) method. The solubility and the in vitro release study of the raw drug, solid dispersions, and the corresponding physical mixtures … Show more
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