Solubility Determination and Thermodynamic Modeling of Methanesulfonamide in 13 Pure Solvents at Temperatures of 283.15–323.15 K

Abstract

In this paper, the solubility of methanesulfonamide (MSAM) in selected 13 pure solvents including 9 alcohols (methanol, ethanol, n-propanol, iso-propanol, n-butanol, sec-butanol, iso-butanol, n-pentanol, and iso-pentanol) and 4 esters (ethyl acetate, propyl acetate, iso-propyl acetate, and methyl propionate) at atmospheric pressure and temperatures from 283.15 to 323.15 K was determined. The solubility as a function of temperature was regressed using modified Apelblat, Van’t Hoff, λh, Wilson, and nonrandom two-liquid (NRTL) models. Based on the experimental and the simulation results, the thermodynamic mixing properties of the solutions, mixing Gibbs energy, enthalpy, and entropy were evaluated.

Determination and Modeling of Artesunate Solubility in 13 Pure Solvents at 283.15–323.15 K

“… a Standard uncertainties are u ( T ) = 0.05 K and u ( p ) = 0.5 kPa. Relative standard uncertainty is u r ( x ) = 0.05. x and x ref are the solubility data of amitriptyline hydrochloride in this work and in ref . …”

“…The stability and accuracy of the equipment were verified by the solubility determination of amitriptyline hydrochloride in propanol in Table 3. 8 The solubility data measured by this work are consistent with the data in ref 8, indicating that the experimental method is feasible. Also, the experimental method was applied and tested in ref 6.…”

“…The model parameters Λ ij can be calculated mathematically using a formula, as in eq 8 (8) where V i and V j are the molar volumes of the solute and solvent, respectively. Δλ ij (J/mol) refers to the binary crossinteraction energy parameters.…”

Determination and Simulation of Menadiol Diacetate Solubility in 14 Solvents at Temperatures from 283.15 to 323.15 K

“…The accuracy of the solubility measurement method has been verified by the determination of the solubility of amitriptyline hydrochloride in our previous paper . The data listed in this paper are the average values of three parallel experiments.…”

“…The masses of the solvents and MDA were measured using an electronic analytical balance with precision of 0.0001 g (Sartorius, CP224S). In the measurements, a small amount of MDA was added into the solvent, and then the dissolution process was monitored by a laser dynamic solubility-monitoring device, which has been described in our previous papers. , Briefly, the device consists of a laser generator, a laser receiver, a transmitter, and an indicator. In the experiments, the laser beam from the laser generator passes through the glass crystallizer and is received by the laser receiver.…”