Solubility Determination and Modeling and Dissolution Thermodynamic Properties of Raspberry Ketone in Binary Solvent Mixtures of Ethanol and Water

Shu, Min; Zhu, Liang; Wang, Yanfei; Yang, Jing; Wang, Li-Yu; Yang, Libin; Zhao, Xiaoyu; Du, Wei

doi:10.1007/s10765-017-2323-6

Cited by 5 publications

(2 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Water + ethanol Trehalose [32] (10), nifedipine [33] (11), L-methionine [34] (12), 4-bromopyrazole [35] (13), 1,3,3-trinitroazetidine (TNAZ) [36] (14), clindamycin phosphate [37] (15), clotrimazole [38] (16), itaconic acid [39] (17), calcium-L-lactate pentahydrate [40] (18), 4-nitropyrazole [24] (19), P-coumaric acid [41] (20), mercaptosuccinic acid [42] (21), sodium thioglycolate [43] (22), M-phenylenediamine [31] (23), maltitol [44] (24), raspberry ketone [45] (25), ethyl maltol [46] (26), calcium formate [47] (27), L-fucose [48] (28)…”

Section: Solvent Solutementioning

confidence: 99%

Solubility correlation by model with partial molar volume

Liu

et al. 2022

Can J Chem Eng

View full text Add to dashboard Cite

Jouyban‐Acree/van't Hoff model was often used to correlate solubility data, which was related to temperature, and the mole fraction of each solvent in the mixture of two solvents. In this work, the partial molar volume of each component in the mixture of two solvents was first time introduced as a modification to the Jouyban‐Acree/van't Hoff model. Furthermore, machine learning and artificial intelligence (AI) technology based on temperature, mole fraction, and partial molar volume of each solvent were employed to improve the accuracy of the solubility estimation. The models were evaluated in terms of their ability to mathematically correlate solute solubility in binary solvents. An average root mean square deviation (RMSD) is used to measure the deviation between the calculated values and the experimental values. With partial molar volume as a modified parameter of the Jouyban‐Acree/van't Hoff model, the overall RMSD of all the correlations of solubility improved.

show abstract

Section: Solvent Solutementioning

confidence: 99%

Solubility correlation by model with partial molar volume

Liu

et al. 2022

Can J Chem Eng

View full text Add to dashboard Cite

show abstract

“…Raspberry ketone is an important flavouring ingredient and is widely used in perfumery and in food and tobacco products 1 . The ketone is also a key chemical intermediate for the synthesis of various compounds used in the pharmaceutical industry.…”

Section: Introductionmentioning

confidence: 99%

Advances in the synthesis and applications of raspberry ketone: A review

Guo

Chang

Jia

et al. 2021

Flavour & Fragrance J

View full text Add to dashboard Cite

Recent advances in the synthesis and applications of raspberry ketone are reviewed in this paper. Different routes to this material including chemical and biotechnological synthetic methods and extraction from natural sources are compared, and the applications of the ketone in flavour and fragrance, pharmaceuticals and in food and tobacco processing are discussed. Synthesis from petrochemical raw materials has the advantages of ready availability of ingredients and well‐understood synthetic steps, but direct synthesis from petrochemicals will eventually be replaced because of low yields and hazardous results to environment. The ketone can be made from natural raw materials, and the methods are promising if their disadvantages such as limited availability and complex, multi‐step reactions and harsh reaction conditions can be overcome. Biotechnological preparation methods have the advantages of reaction specificity, mild reaction conditions, but are limited in applicability because of complications associated with their synthetic and purification procedures at present. With the development of biotechnology, biotechnological preparation methods of the ketone may be the most important route in the future. Direct extraction of the ketone from natural raw materials is possible, but the cost is very high. From the view of syntheses and applications, the research perspectives of raspberry ketone are outlined in the end of this paper, which are the development of green and effective synthetic methods for raspberry ketone from natural raw materials and the preparation and application of raspberry ketone by biotechnological preparation methods.

show abstract