Solubility Determination and Correlation of Glibenclamide in 11 Monosolvents and (Acetone + Acetonitrile) Binary Solvents from 283.15 K to 323.15 K

Abstract

Glibenclamide (GCM) is an oral antihyperglycemic drug and widely used to treat type-II diabetes. The quality of the GCM product impacts the efficacy of the medicine. However, the quality of the product is determined by the crystallization process, in which the solubility property plays a significant role. In this study, GCM solubility in 11 monosolvents (methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, acetone, acetonitrile, methyl isobutyl ketone, methyl acetate and ethyl acetate) and (acetone + acetonitrile) binary solvents, has been determined through a gravimetric method from 283.15 K to 323.15 K. It elucidates that GCM has the highest solubility in acetone among the 11 monsolvents. Meanwhile, the solubility of GCM in (acetone + acetonitrile) binary solvents increases when the mole fraction of acetone rises. Then, we correlated the solubility data in monosolvents using the modified Apelblat model and nonrandom two-liquid (NRTL) model. Besides, the modified Apelblat model, the CNIBS/R-K model, Jouyban–Acree model, and NRTL model were adopted to fit the data in (acetone + acetonitrile) mixture solvents. Furthermore, thermodynamic properties were calculated on the basis of the NRTL model.

Measurement and Correlation of Solubility of Marbofloxacin in 12 Pure Solvents from 283.15 to 328.15 K

“…Buchowski and colleagues first suggested the λ h model, ,, which could also be applied to correlate the solid–liquid equilibrium. The λ h model can be expressed as eq . where λ and h are the model parameters and their values are shown in Table ; x is the mole fraction solubility of marbofloxacin obtained from the experiments at the experimental temperature T in kelvin and can be calculated by eq ; and T m is the melting temperature of marbofloxacin (559.15 K).…”

“…The NRTL model is an activity coefficient equation and commonly applied to correlate the solid–liquid equilibrium. ,, The model can be given as eq . where x is the mole fraction solubility of marbofloxacin obtained from experiments at the experimental temperature T in kelvin; T m is the melting temperature of marbofloxacin in kelvin; Δ fus H is the fusion enthalpy of marbofloxacin; R is the universal gas constant; and γ is the activity coefficient of the solute.…”

Measurement and Correlation of the Solubility of Aspirin in Four Binary Solvent Mixtures from T = 283.15 to 323.15 K

“…The combined nearly ideal binary solvent/Redlich–Kister (CNIBS/R–K) model describes the solubility of the solute in binary solvent systems. It can be shown as eq , where x T is the mole fraction of aspirin in mixed solvents, x 2 , and x 3 refer to the initial mole fractions of the binary mixtures, x 2,T are x 3,T are the solubilities of aspirin in corresponding pure solvents, S i represents the model parameters, and N is the number of “curve-fit” parameter. For the binary solvent mixtures, the value of N is 2 and x 3 = 1 – x 2 ; eq can be simplified as eq where B 1 – B 5 are equation parameters.…”

“…The combined nearly ideal binary solvent/Redlich−Kister (CNIBS/R−K) model describes the solubility of the solute in binary solvent systems. It can be shown as eq 210,11…”

Determination and Correlation of the Solubility of Musk Ketone in Pure and Binary Solvents at 273.15–313.15 K

“…The modified Apelblat equation − (eq ) is derived from the Clausius equation. It is considered to be a convenient model for fitting dissolution equilibrium data.…”