Solubility-dependent complexation of active pharmaceutical ingredients with trimethyl-β-cyclodextrin under supercritical fluid condition

Preparation of inclusion complex of piroxicam with cyclodextrin by using supercritical carbon dioxide

“…Drug References geraniol, mustard oil [12] acetaminophen [13] piroxicam [14,15] miconazole [15,16,17,18,19,20] Eflucimibe [21,22] ibuprofen [23,24,25,26,27,28,29] naproxen [28,30,31,32] flurbiprofen [28] citral, thymol, carvacrol [33] imazalil [34] salicylic acid [35] azobenzene [36] budesonide [37,38,39] indomethacin [40] polyaniline [41] cholesterol [42] arylphosphines [43] itraconazole [44,45,46] 2 sodium salts [47] hydroxyflavone [48] benzocaine [50, 49,] bupivacaine, and mepivacaine [50] simvastatin [51] several triphenyl phosphine derivatives [52] all-trans-lycopene [53] 15 carbohydrates [54] human serum immunoglobulin G …”

Salicylic Acid/γ-Cydodextrin 2:1 and 4:1 Complex Formation by Sealed-Heating Method

“…[14][15][16][17] Sealed-heating, in which both guest and host molecules are heated within an enclosed container, is also a useful technique for preparing inclusion complexes. 18 With the sealed-heating method, crystalline inclusion complexes with poorly water-soluble drugs can be obtained without using an organic solvent.…”

Supercritical Carbon Dioxide as a Green Alternative to Achieve Drug Complexation with Cyclodextrins

“…Two possible complexation mechanisms were proposed. According to Tozuka and coworkers [26,90], complexation occurs because the solubility of the complex in scCO 2 is lower than that of the uncomplexed components, which would result in the precipitation of the complex from the supercritical medium [90]. Recently, another research group [96] proposed a different complexation mechanism, which is based on the experimental measures of the cloud point of both components.…”

“…Literature reports of flurbiprofen complexation by SSI with TMβCD [90], MβCD [87] and HPβCD [65] can be found. While complexation of this drug with TMβCD was hypothesized thanks to the appearance of a new crystalline phase in the X-ray spectra and DSC scans [90] its complexation with MβCD was, on the contrary, supported by sample amorphization as well as molecular docking studies [87].…”