Solubility and Thermodynamic Properties of A Hexanediamine Derivative in Pure Organic Solvents and Nonaqueous Solvent Mixtures

Determination and Correlation of Solubility of N-Acetylglucosamine in Four Aqueous Binary Solvents from 283.15 to 323.15 K

“…The CNIBS/R-K model may be used to illustrate the link between the solvent composition and the isothermal mole fraction solubility of a binary solvent combination. − The expression is shown in eq . ln 0.25em x 1 = x 2 0 ln 0.25em x A + x 3 0 ln 0.25em x B + x 2 0 x 3 0 ∑ i = 0 n S i false( x 2 0 − x 3 0 false) i where x 1 is the solute’s mole fraction solubility. The saturated mole solubilities of the solute in the respective pure solvents are denoted by the letters x A and x B .…”

Phytic Acid-Modulated Ru Catalyzes Regioselective Deuteration of 1,6-Hexamethylenediamine

“…Deuterium-labeled compounds have become essential tools in various fields of scientific research, including life, environmental, and materials science. − Primary amine units are critical and widely utilized components of many drugs, with over 50% of the 200 drugs with the highest retail sales containing the amine fraction as the key pharmacodynamic group. , Many bioactive amines are metabolized through oxidative deamination by oxidase enzymes . Hence, incorporating deuterium at the C–H bond adjacent to the nitrogen atom of the primary amine can significantly enhance in vivo efficacy due to the stronger C–D bond. − As a simple primary amine compound, 1,6-hexamethylenediamine is an intermediate for the synthesis of a variety of organic compounds, and deuterated 1,6-hexamethylenediamine can be used to label biological macromolecules, such as proteins, nucleic acids, and polysaccharides, to study their biological functions and metabolic pathways. , Therefore, exploring the deuteration reaction system of primary amine compounds using 1,6-hexamethylenediamine as the research object is of great significance.…”

“…6−8 As a simple primary amine compound, 1,6-hexamethylenediamine is an intermediate for the synthesis of a variety of organic compounds, and deuterated 1,6-hexamethylenediamine can be used to label biological macromolecules, such as proteins, nucleic acids, and polysaccharides, to study their biological functions and metabolic pathways. 9,10 Therefore, exploring the deuteration reaction system of primary amine compounds using 1,6hexamethylenediamine as the research object is of great significance.…”