“…Deuterium-labeled compounds have become essential tools in various fields of scientific research, including life, environmental, and materials science. − Primary amine units are critical and widely utilized components of many drugs, with over 50% of the 200 drugs with the highest retail sales containing the amine fraction as the key pharmacodynamic group. , Many bioactive amines are metabolized through oxidative deamination by oxidase enzymes . Hence, incorporating deuterium at the C–H bond adjacent to the nitrogen atom of the primary amine can significantly enhance in vivo efficacy due to the stronger C–D bond. − As a simple primary amine compound, 1,6-hexamethylenediamine is an intermediate for the synthesis of a variety of organic compounds, and deuterated 1,6-hexamethylenediamine can be used to label biological macromolecules, such as proteins, nucleic acids, and polysaccharides, to study their biological functions and metabolic pathways. , Therefore, exploring the deuteration reaction system of primary amine compounds using 1,6-hexamethylenediamine as the research object is of great significance.…”