The solubility of musk ketone in four pure solvents (methanol,
ethanol, n-butanol, and ethyl acetate) and three
binary mixed solvents (methanol + ethanol, ethanol + ethyl acetate,
and n-butanol + ethyl acetate) at different temperatures
(273.15–313.15 K) was determined by the static equilibrium
method. The results showed that the solubility of musk ketone in the
above solvents increases with the increasing temperature. The musk
ketone has different solubilities in four pure solvents under the
same environmental conditions (ethyl acetate > n-butanol > ethanol > methanol). In the binary solvent of methanol
+ ethanol, the solubility of musk ketone was positively correlated
with the mass fraction of ethanol. In the binary mixed solvents of
ethanol + ethyl acetate and n-butanol + ethyl acetate,
the solubility was positively correlated with the mass fraction of
ethyl acetate. Seven thermodynamic equations (van’t Hoff equation,
modified Apelblat equation, λh equation, nonrandom
two-liquid model, Wilson model, Jouyban–Acree model, and Sun
model) were used to correlate the experimental solubility data. The
deviation between the experimental values and the correlated values
was calculated and analyzed. The results showed that these models
can predict the experimental results very well. In addition, the Hansen
solubility parameters of musk ketone and the solvents were calculated
and discussed. The results showed that the non-hydrogen bond interaction
has a great influence on the solubility of musk ketone.