Solubility and Solution Thermodynamics of Tylosin in Pure Solvents and Mixed Solvents at Various Temperatures

Abstract

Thermodynamic data of drug is important to industrial design and industrial application. In this paper, solubility data of tylosin in pure solvents and acetone +water mixture solvents were experimentally determined from 279.75 K to 323.15 K. The experiment results indicated that solubility of tylosin in pure solvents gradually decreased and followed this order: chloroform > buty lacetate > acetonitrile > tetrahydrofuran > acetone > benzene > n-butanol > ethy lacetate > n-propanol > ethanol > methanol > water, and solubility gradually decreased with water increasing in water+acetone mixture solvents. Moreover, experimental solubility increased with temperature increasing except for water(x ≥ c 0.9281)+acetone mixture solvents. Thermodynamic models correlating solubility data showed that modified Apelblat model was litter better agreement than Van't Hoff model, Wilson model, NRTL model in pure solvents and C/R-K model, Jouyban Acree model in acetone+water 2 solvents by ARD, RMSD and R. Furthermore, thermodynamic properties for dissolution process of tylosin were calculated and discussed by modified Apelblat model paramaters.