Solubility and pKa of select pharmaceuticals in water, ethanol, and 1-octanol

Cyclofructan 6 based stationary phases for hydrophilic interaction liquid chromatography

“…The retention factors of nadolol and atenolol increased with the pH on all columns except for the DCH-CF6. The sharpest increase was observed in the range of 4.0-5.0, which correspond to the pK b s of these compounds (nadolol, pK b = 4.3; atenolol pK b = 4.4) [48]. The highest retention resulted from two columns, i.e., the L-CF6 and Astec…”

Study of phase equilibria and the physicochemical properties of selected pharmaceuticals

“…The main factor is the solubility of the drug in the target tissue. Today the solubility of drugs is measured with different methods: for very low solubility the classical staticsaturation shake-flask method at one temperature is commonly used and for lower solubility the visual, dynamic method, where the solubility as a function of temperature is obtained [1]. Therefore, the drug development is a very laborious and expensive process.…”

“…It is one of the adrenergic amines that stimulates the beta-3 receptors with minimal impact on the other receptor sites. Stimulation of these receptors elicits the breakdown of lipolysis [9]. The action of this drug is similar to ephedrine, therefore it is considered to be a natural substitute.…”

Modelling, solubility and pKa of five sparingly soluble drugs

“…The rate and extent of entry of an orally delivered drug from the gastrointestinal luminal fluid into the blood stream depends on solubility in water, which is usually extremely low (Lipiński, 2000(Lipiński, , 2002Jinno et al, 2000;Domańska et al, 2009).…”