Solubility and mixing thermodynamics properties of erythromycin ethylsuccinate in different organic solvents

Zhang, Xia; Yin, Qiuxiang; Li, Xiang; Zhang, Meijing; Huang, Jinpei; Wang, Chang; Zhang, Zaixiang; Huang, Yao-Hui; Guo, Mingxia; Li, Yang

doi:10.1016/j.molliq.2017.04.081

Cited by 12 publications

(8 citation statements)

References 31 publications

(22 reference statements)

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“…The NRTL model is widely used to estimate the solid–liquid equilibrium properties, especially for many nonideal solutions. It is one of the commonly used activity coefficient equations. , The expression of the equation is obtained as follows where x 1 and x 2 represent the mole fraction of the solute and solvent, respectively, and Δ g 12 (= g 12 – g 22 ) and Δ g 21 (= g 21 – g 11 ) represent the interaction parameters. Δ g 12 and Δ g 21 do not change with the composition and temperature, respectively.…”

Section: Resultsmentioning

confidence: 99%

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Measurement and Correlation of the Solubility of Gestodene in 11 Pure and Binary Mixed Solvent Systems at Temperatures from 283.15 to 323.15 K

Chen

Jia

et al. 2021

J. Chem. Eng. Data

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The solubility of gestodene in 11 different monosolvents (methanol, ethanol, n-propanol, 1-butanol, isopropanol, isopropyl acetate, ethyl acetate, acetone, butanone, acetonitrile, and water) and a binary solvent of methanol + water was determined at different temperatures ranging from 283.15 to 323.15 K by the shake flask method. The solubility of gestodene in the selected pure solvents and methanol + water binary systems rose with the augmented temperatures. The maximum solubility value of gestodene was recorded in isopropyl acetate and the minimum in water. The modified Apelblat, Van't Hoff, λh, NRTL, UNIQUAC, and Wilson equations described the solubility data in pure solvents. In addition, the modified Apelblat, Van't Hoff, λh, Jouyban−Van't, and Jouyban−Apelblat equations were employed to describe the solubility data in binary solvents. It could be concluded that the Apelblat model provided the best fitting result among the 11 pure and mixed solvents. The research can also provide a theoretical basis for industrial crystallization production.

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Section: Resultsmentioning

confidence: 99%

“…It is one of the commonly used activity coefficient equations. 27,28 The expression of the equation is obtained as follows i k j j j j j y 3.4.6. UNIQUAC Equation.…”

Section: Local Composition Modelmentioning

confidence: 99%

Measurement and Correlation of the Solubility of Gestodene in 11 Pure and Binary Mixed Solvent Systems at Temperatures from 283.15 to 323.15 K

Chen

Jia

et al. 2021

J. Chem. Eng. Data

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“…The average relative deviation (ARD) is commonly applied to evaluate the correlation, , which is expressed as follows where N p refers to the number of experimental data points in the selected solvent; x 1, i refers to the experimental solubility data; and x 1,i cal refers to the calculated solubility data calculated by the selected model. The calculated ARD values for the selected solvents and the selected models or equations are listed in Table .…”

Section: Resultsmentioning

confidence: 99%

“…Average Relative Deviation. The average relative deviation (ARD) is commonly applied to evaluate the correlation, 15,30 which is expressed as follows…”

Section: Correlation Of the Experimental Solubility Datamentioning

confidence: 99%

“…In this work, the solubility data of probenecid in 12 different organic solvents including methanol, methyl acetate, ethanol, ethyl acetate, n -propanol, n -butanol, butyl acetate, n -pentanol, isopropanol, isobutanol, acetone and methyl tert -butyl ether were measured using the gravimetric method over the temperatures range from 283.15K to 323.15K at 0.1 MPa. , Three models, including the modified Apelblat equation, van’t Hoff equation, and nonrandom two-liquid (NRTL) model, were applied to correlated the measured solubility data. The thermodynamic properties of mixing were calculated by the correlation results of the NRTL model.…”

Section: Introductionmentioning

confidence: 99%

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Solubility Measurement and Correlation of Probenecid in 12 Pure Organic Solvents and Thermodynamic Properties of Mixing of Solutions

et al. 2019

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The solubility data of probenecid in 12 different organic solvents including methanol, methyl acetate, ethanol, ethyl acetate, n-propanol, n-butanol, butyl acetate, n-pentanol, isopropanol, isobutanol, acetone, and methyl tert-butyl ether was measured using the gravimetric method over the temperatures range from 283.15 to 323.15 K at 0.1 MPa. The acetone had much higher solubility to probenecid than to other solvents. Three models, including the modified Apelblat equation, the van’t Hoff model, and the nonrandom two-liquid (NRTL) model, were applied to correlate the measured solubility data. The correlation results were evaluated by the average relative deviation (ARD). All of the ARD values were less than 4.522%, which indicated that the three models have a satisfactory correlation. The thermodynamic properties of mixing of probenecid in 12 pure organic solvents including the enthalpy of mixing, Gibbs energy of mixing, and entropy of mixing were calculated by the NRTL model using the correlation results.

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Determination and Correlation of the Solubility of Acetylpyrazine in Pure Solvents and Binary Solvent Mixtures

Zhou

Zhang

et al. 2018

J Solution Chem

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Solubility and mixing thermodynamics properties of erythromycin ethylsuccinate in different organic solvents

Cited by 12 publications

References 31 publications

Measurement and Correlation of the Solubility of Gestodene in 11 Pure and Binary Mixed Solvent Systems at Temperatures from 283.15 to 323.15 K

Measurement and Correlation of the Solubility of Gestodene in 11 Pure and Binary Mixed Solvent Systems at Temperatures from 283.15 to 323.15 K

Solubility Measurement and Correlation of Probenecid in 12 Pure Organic Solvents and Thermodynamic Properties of Mixing of Solutions

Determination and Correlation of the Solubility of Acetylpyrazine in Pure Solvents and Binary Solvent Mixtures

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