Solubility and Hansen Solubility Parameter of N_α-Carbobenzyloxy-l-Arginine in Twelve Individual Solvents from 283.15 to 323.15 K

Abstract

The solubility data of N α -carbobenzyloxy-L-arginine in 12 individual solvents (water, dimethylformamide, methanol, ethanol, isopropanol, 1-butanol, acetone, acetonitrile, dichloromethane, ethyl acetate, and 2-butanone) were determined by the static gravimetric method in the temperature range from 283.15 to 323.15 K. The results show that all the solubility increases with the increase in temperature. In the selected solvent systems, three different polymorphs named the α-form, β-form, and γ-form were found. In addition, the Hansen solubility parameters (HSPs) were used to analyze the dissolution behavior. According to the solubility data analysis results, the dissolution behavior was affected by the HSPs, polarity, hydrogen bond, and cohesive energy density. The Apelblat model and the Yaws model were used to correlate the solubility data, and their fitting effect was evaluated by the Akaike information criterion method.

Equilibrium Solubility of Domiphen Bromide in 12 Mono Solvents: Determination and Correlation

“…The solubility of domiphen bromide in 12 mono solvents (ethanol, n -propanol, n -butanol, 1-pentanol, iso -propanol, iso -butanol, tert -butanol, DMF, DMA, NMP, acetonitrile, and DMSO) was determined by the gravimetric method at temperatures ranging from 283.15 to 323.15 K according to previous studies and the literature. − Excess domiphen bromide and 40 mL of solvent were added into a 120 mL double-jacketed glass container that was connected to a thermostatic water bath (DCW-4006, Shanghai Bilon Instrument Co. Ltd., China). The experimental device is shown in Figure .…”

“…The λ h model is a semiempirical model first proposed by Buchowski et al This model describes the relationship between the solubility, melting point, and experimental temperature, , as given in eq . ln [ 1 + λ false( 1 − x false) x ] = λ h true( 1 false( T / K false) − 1 ( T normalm / K ) ) Here, λ and h are two model parameters, T m is 390.15 K (from the literature), and RD , RAD , and rmsd of the fitting results are expressed by eqs –8, respectively. − italicRD = x e i xp − x i calcd x i exp italicRAD = 1 n ∑ i − 1 n | x i exp − x i calcd x i exp | rmsd = true[ 1 n ∑ i − 1 n false( x …”

“…The λ h model is a semiempirical model first proposed by Buchowski et al This model describes the relationship between the solubility, melting point, and experimental temperature, , as given in eq . Here, λ and h are two model parameters, T m is 390.15 K (from the literature), and RD , RAD , and rmsd of the fitting results are expressed by eqs –8, respectively. − In eqs –, x i exp and x icalcd denote the experiment value and calculated value, respectively.…”

Solid–Liquid Equilibrium Behavior and Solvent Effect of Gliclazide in Mono- and Binary Solvents

“…Solution crystallization plays a significant role in separating and purifying products in pharmaceutical production, which determines the purity, particle size, and the final yield of products . Crystal properties of drugs will significantly affect the bioavailability, release, metabolism, and excretion of drugs. , The solubility data of drugs are particularly important for the design and optimization of the crystallization process, which can provide the necessary parameters for crystallization process design.…”