Solubility and Data Correlation of β-Arbutin in Different Monosolvents from 283.15 to 323.15 K

Abstract

The solubility of β-arbutin (ARB) in 12 different monosolvents (methanol, ethanol, propanol, isopropanol, butyl alcohol, isobutanol, ethyleneglycol, acetone, 2-butanone, acetonitrile, methyl acetate, and ethyl acetate) from 283.15 to 323.15 K at atmospheric pressure was measured by gravimetric method. The solubility data show an increasing trend with increasing temperature. The solubility is related to many factors like polarity, H-bond, cohesive energy density, etc. The solubility of ARB was correlated by the Apelblat model, λh model, Van’t Hoff equation, and nonrandom two-liquid (NRTL) model. Also, the Apelblat model shows a better fitting result compared with other three models through calculating the value of ARD. Besides, the dissolution thermodynamic properties (the dissolution Gibbs energy, enthalpy, and entropy) were evaluated, which revealed that the dissolution of ARB was a spontaneous and exothermic process.

Solubility and Model Correlation of Doxofylline in Pure Solvents at the Temperature Range of 283.15–323.15 K

“…The three-parameter Van’t Hoff model directly shows the relationship between the mole fraction solubility of a solute and system temperature. ,, This model was derived from the Van’t Hoff equation, as shown in eq . where A , B , and C are also model parameters.…”

“…The thermodynamic mixing properties, the Gibbs energy (G), enthalpy (H), and entropy (S), provide information about the direction and limits of the dissolution and crystallization process. 25 Therefore, in this work, the thermodynamic mixing properties of DFL in the 17 solvents were evaluated based on the solubility data. ), and The thermodynamic mixing properties of the dissolution process can be expressed by eq 14 17,18,25 The activity coefficient (γ 1…”

“…25 Therefore, in this work, the thermodynamic mixing properties of DFL in the 17 solvents were evaluated based on the solubility data. ), and The thermodynamic mixing properties of the dissolution process can be expressed by eq 14 17,18,25 The activity coefficient (γ 1…”

“…where M = G, H, and S. Δ mix M is the thermodynamic mixing property. The superscript E refers to the excess properties and id the ideal solution.Based on the experimental solubility data and the parameters of the Wilson model, the excess mixing properties can be evaluated by eqs 15−2017,18,25 …”

Determination and Data Correlation of Solubility of Sofosbuvir Polymorphs in Ethyl Acetate + Toluene and Methyl tert-Butyl Ether Binary Solvents at the Temperature Range from 268.15 to 308.15 K

“…These are important for the optimization of the crystallization process, especially for the controlling of polymorphs, since the various solid forms generally present different physicochemical properties. In this study, a gravimetric method [4][5][6] was used to acquire the solubility data of sofosbuvir of forms A and B in both ethyl acetate + toluene binary solvents with ethyl acetate mole fraction Crystals 2020, 10, 209; doi:10.3390/cryst10030209 www.mdpi.com/journal/crystals ranging from 0.32 to 0.53, and MTBE + toluene binary solvents with MTBE mole fraction ranging from 0.40 to 0.77, at atmosphere pressure, with a temperature range of 268.15−308.15 K. The experimental data were correlated using the modified Apelblat model, the CNIBS (combined nearly ideal binary solvent)/Redlich-Kister model, and the combined version of Jouyban-Acree model. A stability test according to International Conference for Harmonization Quality Guidelines was conducted as well, to disclose the solid-state stability of sofosbuvir polymorphs under the influence of a variety of environmental factors such as temperature, humidity, and light.…”