Solubilities of calcium salts of dicarboxylic acids in methanol-water mixtures; transfer chemical potentials of dicarboxylate anions

Burgess, John; Drasdo, Duncan N.

doi:10.1016/s0277-5387(00)80037-6

Cited by 14 publications

(4 citation statements)

References 24 publications

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“…37 This observation is consistent with the severely reduced solubility of vicinal dicarboxylate species with Ca 2+ , as compared with other dicarboxylate chelators. 38,39 Lipid Dependency on Protein-Free Nanodisc Formation Previous studies of SMA copolymers report no solubilization preference toward specific types of lipids. [40][41][42] To determine whether the lipid composition has an effect on the solubilization efficiency of AASTY copolymers, we formed protein-free AASTYstabilized nanodiscs incorporating 2% of the fluorescent Lissamine Rhodamine B (Liss Rhod) phosphatidylethanolamine (PE) lipid with three different lipid mixtures:…”

Section: Articlementioning

confidence: 99%

Lipid Nanodiscs via Ordered Copolymers

Smith

Autzen

Faust

et al. 2020

Chem

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A highly alternating copolymer composed of acrylic acid and styrene (AASTY) is synthesized with controlled radical polymerization by exploiting the reactivity ratios of the monomers to control the monomer sequence. The AASTY copolymers are effective solubilizers of cellular membranes and their embedded proteins, which improves structural characterization by single-particle cryo-electron microscopy (cryo-EM). These copolymers are promising tools for exploring detergent-free membrane protein solubilization and direct formation of native nanodiscs, facilitating structural and functional analysis of the mammalian proteome.

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Section: Articlementioning

confidence: 99%

Lipid Nanodiscs via Ordered Copolymers

Smith

Autzen

Faust

et al. 2020

Chem

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“…Oxalate ions are generated in the liver by glyoxalate metabolism, but due to low solubility they are carried at low concentrations in the plasma membrane [38]. Previous studies have shown that oxalate is quickly taken up by proximal tubule cells and high concentration of oxalate can be excreted in urine by the secretary pathway [39, 40].…”

Section: Oxalate and Calcium Oxalate Induced Injurymentioning

confidence: 99%

NADPH Oxidase as a Therapeutic Target for Oxalate Induced Injury in Kidneys

Joshi

Peck

Khan

2013

Oxidative Medicine and Cellular Longevity

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A major role of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase family of enzymes is to catalyze the production of superoxides and other reactive oxygen species (ROS). These ROS, in turn, play a key role as messengers in cell signal transduction and cell cycling, but when they are produced in excess they can lead to oxidative stress (OS). Oxidative stress in the kidneys is now considered a major cause of renal injury and inflammation, giving rise to a variety of pathological disorders. In this review, we discuss the putative role of oxalate in producing oxidative stress via the production of reactive oxygen species by isoforms of NADPH oxidases expressed in different cellular locations of the kidneys. Most renal cells produce ROS, and recent data indicate a direct correlation between upregulated gene expressions of NADPH oxidase, ROS, and inflammation. Renal tissue expression of multiple NADPH oxidase isoforms most likely will impact the future use of different antioxidants and NADPH oxidase inhibitors to minimize OS and renal tissue injury in hyperoxaluria-induced kidney stone disease.

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“…It seems that cisplatin, carboplatin and iproplatin do not show such potentially advantageous solvation characteristics, but rather show solubility behavior approximating to the linear dependence of log(solubility) on volume % organic cosolvent often used as a rule-of-thumb guide for estimating solubilities of lipophilic organic drugs (Hardaway & Yalkowsky 1991). Interestingly, the CBDC (cyclobutane-1,1-dicarboxylate) ligand of carboplatin is markedly hydrophilic, with a transfer chemical potential curve (Burgess & Drasdo 1993) rather close to that shown in Figure 1 for [PtCI6] 2-. It may be that third generation platinum anticancer drugs containing rather more lipophilic ligands may prove to have better membrane-crossing properties and thus prove more effective.…”

Section: Resultsmentioning

confidence: 99%