Solubilities of 2-Methyl-1,4-naphthoquinone in Water + (Methanol, Ethanol, 1-Propanol, 2-Propanol, 1,2-Propanediol, and Glycerin, Respectively) from (293.15 to 337.92) K

Section: Methodsmentioning

confidence: 99%

Measurement and Correlation for Solubility of 2-Bromopropane and Thiourea in Water

Guo

Zhao

2009

“…Although MeOH is not acceptable pharmaceutically because of its toxicity, it can also be used in other applications in chemical/ pharmaceutical industries, and as per our literature findings, still it has been extensively used in recrystallization of drugs and was also employed by several authors as a model cosolvent for prediction of drug solubility. 33,42 Several temperature-dependent studies proved the potential use of glycerin for solubilization of furosemide, 43 menadione sodium bisulfite, 44 2-methyl-1,4-naphthoquinone, 45 p-aminophenol, 46 and paracetamol 47 in binary solvent systems in all possible proportions. The polymerized derivatives of ethylene glycols (EGs), mainly, lower molecular weight liquid PEGs 200, 400, and 600 are similar in structure and widely accepted industrial solvents for preclinical and clinical studies 48 because of their favorable properties such as nonirritating, low volatility, low toxicity, low melting point, high chemical stability, and complete miscibility with water.…”

Section: ■ Introductionmentioning

confidence: 99%

Solubility of Etoricoxib in Aqueous Solutions of Glycerin, Methanol, Polyethylene Glycols 200, 400, 600, and Propylene Glycol at 298.2 K

Rathi¹,

Kale

Soleymani

et al. 2018

Experimental molar solubility of etoricoxib (ETR) in monosolvents such as glycerin, methanol (MeOH), polyethylene glycol 200 (PEG 200), polyethylene glycol 400 (PEG 400), polyethylene glycol 600 (PEG 600), propylene glycol (PG), and their aqueous binary solvent systems in various mass fraction compositions along with the solute-free and saturated solution densities were measured at 298.2 K. The resulting mole fraction solubility and density data were further correlated and predicted with the Jouyban−Acree model. Overall mean percentage deviations (OMPDs) between experimental and calculated mole fraction solubilities were 3.5%. The solute-free density of the monosolvents and their aqueous binary solvent systems were employed to train the model and then the densities of the saturated solutions were predicted. Moreover, OMPDs for back calculated solute-free densities and predicted saturated solution densities were 0.07% and 0.40%, respectively. Thus, the Jouyban−Acree model have potential use in preformulation and formulation studies during which solubility and density calculations are important physicochemical properties for design and development of new drug products in pharmaceutical industries. The simulated data could also be employed in crystallization and other related process design in the pharmaceutical/chemical industry.

“…It is well-known that the solubility plays an important role in optimizing the crystallization procedure and improving the purity and yield of the solid compound. The solubility data and reliable phase diagrams of the ternary and multicomponent mixtures are very important in the crystallization process. − The solubility of 2-MNQ in several common organic solvents were reported in the published papers. − Recently, Zhang and co-workers , reported the solid–liquid equilibrium phase diagrams for the ternary 2-MNQ + PA + acetone and 2-naphthaldehyde + o-phthalic anhydride +1,4-dioxane system at different temperatures. In order to add to our knowledge of the solubility and provide the comprehensive basic data for engineering application, it is essential to study on solid–liquid equilibrium phase diagrams for the ternary 2-MNQ + PA + 1,4-dioxane system.…”

Section: Introductionmentioning

confidence: 99%

Solid–Liquid Equilibrium and Phase Diagram for Ternary 2-Methyl-1,4-naphthoquinone + Phthalic Anhydride +1,4-Dioxane System

Zhang

Zhu

et al. 2017

The solid−liquid equilibria (SLE) in the ternary system of 2-methyl-1,4naphthoquinone (2-MNQ) + phthalic anhydride (PA) + 1,4-dioxane were determined experimentally by using the isothermal dissolution equilibriam method within temperatures 283.15, 293.15, and 303.15 K, respectively. The ternary phase diagram could be helpful in the separation of 2-MNQ and PA. On the basis of the experimental data on solubilities the phase diagrams of the system were plotted. Two pure solid phases were formed at 283.15, 293.15 and 303.15 K, including pure PA and pure 2-MNQ, which were confirmed and determined by Schreinemakers' wet residue method. The phase diagram at 283.15 K is similar to those at 293.15 and 303.15 K and the crystalline regions of 2-MNQ and PA decrease with increasing temperature. NRTL and Wilson model were employed to correlate and calculate the solubility data for the ternary system. A comparison between the two models shows that the NRTL model agrees better with the experimental data than those with the Wilson model. In addition, the densities of equilibrium liquid phase were obtained at the corresponding temperatures versus composition in the system.